antiviral drugs

Amantadine hydrochloride (CI-719) 是一种抗病毒药物，用于预防或对症治疗甲型流感和帕金森病。它阻断质子流通过 M2 离子通道，从而阻止病毒 RNA 释放到感染细胞的细胞质中。

Amantadine (1-Aminoadamantane) 是抗病毒药物，也是是 NMDA 型谷氨酸受体的弱拮抗剂，能促进高多巴胺的释放，并阻断多巴胺的再摄取。

6-ethenylquinoline 是一种结构独特的芳香杂环化合物，是生产其他芳香族化合物的重要中间体，并被用作合成各种药物的起始材料，包括抗真菌剂、抗寄生虫剂和抗病毒剂。它已被证明是多种参与药物代谢的酶的抑制剂，包括细胞色素P450、醛氧化酶和黄嘌呤氧化酶等。

Pixatimod（又名PG-545）是一种合成的改性糖类肝素硫酸模拟剂及Toll样受体9（TLR9）的激动剂，具有潜在的免疫刺激、抗肿瘤和抗病毒活性。Pixatimod强效抑制SARS-CoV-2，其通过破坏刺突蛋白-ACE2的相互作用来实现。此外，Pixatimod阻断了多种促癌过程，包括细胞增殖、侵袭、转移、血管生成及上皮-间充质转换。这些活性在多种不同的小鼠癌症模型中显示出强大效果，涵盖约30种异种移植模型和20种同源移植模型。Pixatimod已与多种已获批准的抗癌化合物联合测试，展现其临床潜力，包括与吉西他滨、紫杉醇、索拉非尼、铂类化合物和一种抗PD-1抗体的联合应用。

3-Hydroxyterphenyllin is a p-terphenyl fungal metabolite originally isolated from A. candidus that has diverse biological activities, including antioxidant, antiproliferative, antibacterial, and antiviral properties.1,2,3,4 It has a 96% scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radicals when used at a concentration of 100 μg/ml.2 3-Hydroxyterphenyllin inhibits the growth of HeLa cervical, A549 lung, and HepG2 liver cancer cells (IC50s = 23, 36, and 32 μM, respectively), as well as methicillin-resistant S. aureus (MRSA) and V. vulnificus bacteria (MIC = 31 μg/ml for both).3 It also inhibits HIV-1 integrase in both coupled and strand transfer assays (IC50s = 2.8 and 12.1 μM, respectively).4References1. Kurobane, I., Vining, L.C., McInnes, A.G., et al. 3-Hydroxyterphenyllin, a new metabolite of Aspergillus candidus. Structure elucidation by 1H and 13C nuclear magnetic resonance spectroscopy. J. Antibiot. (Tokyo) 32(6), 559-564 (1979).2. Yen, G.-C., Chang, Y.-C., Sheu, F., et al. Isolation and characterization of antioxidant compounds from Aspergillus candidus broth filtrate. J. Agric. Food Chem. 49(3), 1426-1431 (2001).3. Wang, W., Liao, Y., Tang, C., et al. Cytotoxic and antibacterial compounds from the coral-derived fungus Aspergillus tritici SP2-8-1. Mar. Drugs 15(11), E348 (2017).4. Singh, S.B., Jayasuriya, H., Dewey, R., et al. Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites. J. Ind. Microbiol. Biotechnol. 30(12), 721-731 (2003). 3-Hydroxyterphenyllin is a p-terphenyl fungal metabolite originally isolated from A. candidus that has diverse biological activities, including antioxidant, antiproliferative, antibacterial, and antiviral properties.1,2,3,4 It has a 96% scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radicals when used at a concentration of 100 μg/ml.2 3-Hydroxyterphenyllin inhibits the growth of HeLa cervical, A549 lung, and HepG2 liver cancer cells (IC50s = 23, 36, and 32 μM, respectively), as well as methicillin-resistant S. aureus (MRSA) and V. vulnificus bacteria (MIC = 31 μg/ml for both).3 It also inhibits HIV-1 integrase in both coupled and strand transfer assays (IC50s = 2.8 and 12.1 μM, respectively).4 References1. Kurobane, I., Vining, L.C., McInnes, A.G., et al. 3-Hydroxyterphenyllin, a new metabolite of Aspergillus candidus. Structure elucidation by 1H and 13C nuclear magnetic resonance spectroscopy. J. Antibiot. (Tokyo) 32(6), 559-564 (1979).2. Yen, G.-C., Chang, Y.-C., Sheu, F., et al. Isolation and characterization of antioxidant compounds from Aspergillus candidus broth filtrate. J. Agric. Food Chem. 49(3), 1426-1431 (2001).3. Wang, W., Liao, Y., Tang, C., et al. Cytotoxic and antibacterial compounds from the coral-derived fungus Aspergillus tritici SP2-8-1. Mar. Drugs 15(11), E348 (2017).4. Singh, S.B., Jayasuriya, H., Dewey, R., et al. Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites. J. Ind. Microbiol. Biotechnol. 30(12), 721-731 (2003).

SARS-CoV-2-IN-10 is a powerful and non-toxic inhibitor of SARS-CoV-2 3CL protease, with IC50 and EC50 values of 0.13 nM and 1.03 nM, respectively. The SARS-CoV-2 3C-like protease (3CLpro) is a critical enzyme for viral replication and serves as an ideal target for intervention. By targeting the SARS-CoV-2 3CL protease, SARS-CoV-2-IN-10 has the potential to facilitate the development of effective antiviral drugs specific to SARS-CoV-2.

SARS-CoV-2 3CLpro-IN-1 (Compound 14c) is a highly potent inhibitor specifically designed to target and inhibit the activity of SARS-CoV-2 3CL pro, which is a cysteine-protease found in the main coronaviruses. This particular enzyme has been recognized as a highly promising target for the development of effective antiviral drugs. Therefore, SARS-CoV-2 3CLpro-IN-1 holds significant potential for advancing research and development in the field of infectious diseases [1].

L-Xylulose is an intermediate in certain metabolic pathways and is classified as a rare sugar. It shows important physiological effects such as acting as an inhibitor of α-glucosidase and decreasing blood glucose, and it can be employed to produce other significant rare sugars, such as L-ribose and L-xylose which contribute to the production of antiviral drugs.

Nucleoside Derivatives –6-Modified purine nucleosides;N-Methylated nucleosides; Drugs and Inhibitors; Antiviral agent

Nucleoside Derivatives - 7-Deaza-purine nucleosides; Drugs and Inhibitors; Antiviral agent, anti-HCV

Nucleoside Derivatives - Azido-nucleosides, 2'-Modified nucleosides; Drugs and Inhibitors; antiviral agent, DNA synthesis inhibitor; Ribonucleotide reductase inhibitor

Nucleoside Derivatives - 3'-Deoxy nucleosides; Drugs and Inhibitors; Antiviral agent

Nucleoside Derivatives - 6-Modified purine nucleosides; Drugs and Inhibitors; Antiviral agent, cytokinin nucleoside

3-Deoxy-1,2;5,6-di-O-isopropylidene-D-glucofuranose 是一种多糖类的低聚糖。它用于糖基化的合成，可以定制合成用作药物中的碳水化合物。它通过抑制病毒蛋白合成而对Epstein-Barr 病毒具有抗病毒活性。

2',3'-Bis-(O-t-butyldimethylsilyl)uridine是一种核苷衍生物，具有保护核苷的NH2 OH基团的能力，在核苷类似物和抗病毒药物的合成（如AZT and acyclovir）中具有重要应用。对病毒复制有抑制作用，使其有助于对抗艾滋病和疱疹等疾病。

Nucleoside Derivatives - Fluoro-modified nucleosides; 2',3'-Dideoxy nucleosides; Drugs and Inhbitors; Antiviral agent

Nucleoside Derivatives - 5-Modified pyrimidine nucleosides; Azido-nucleosides; 2',3'-Dideoxy nucleosides; Drugs and Inhibitors; Antiviral agent

8-Aminoquinoline 属于分子砌块，是许多天然产物、功能性材料和有用药物中常见的含氮杂环骨架。8-Aminoquinoline 具有抗菌、抗病毒和抗肿瘤等活性，可作为杀虫剂和除草剂的活性成分。