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Lipoxygenase

Lipoxygenase

Lipoxygenases are a family of (non-heme) iron-containing enzymes most of which catalyze the dioxygenation of polyunsaturated fatty acids in lipids containing a cis,cis-1,4- pentadiene into cell signaling agents that serve diverse roles as autocrine signals that regulate the function of their parent cells, paracrine signals that regulate the function of nearby cells, and endocrine signals that regulate the function of distant cells.The lipoxygenases are related to each other based upon their similar genetic structure and dioxygenation activity. However, one lipoxygenase, ALOXE3, while having a lipoxygenase genetic structure, possesses relatively little dioxygenation activity; rather its primary activity appears to be as an isomerase that catalyzes the conversion of hydroperoxy unsaturated fatty acids to their 1,5-epoxide, hydroxyl derivatives.
TargetMol
1 2 3 4 5 6
Cat. No. Product Name CAS No. Purity Chemical Structure
T17191 Bunaprolast
布那司特
99107-52-5 99.9%
TargetMol Chemical Structure Bunaprolast
Bunaprolast (U66858) 是一种新型有效的白三烯 B4 (LTB4) 抑制剂。Bunaprolast 具有氧化降解活性,对脂氧合酶 (lipoxygenase)和 TXB2 释放具有抑制作用。
T27026 CJ-13,610
化合物CJ-13,610
179420-17-8 99.64%
TargetMol Chemical Structure CJ-13,610
CJ-13,610 是一种具有口服活性的非氧化还原型 5-脂氧合酶 (5-LOX) 抑制剂。 CJ-13,610 抑制白三烯 B4 的生物合成并调节巨噬细胞中 IL-6 mRNA 的表达。
T37974 (S)-Coriolic acid
化合物(S)-Coriolic acid
29623-28-7 97.11%
TargetMol Chemical Structure (S)-Coriolic acid
(S)-Coriolic acid (13(S)-HODE) 是一种重要的细胞内信号剂,是亚油酸与植物和哺乳动物脂氧合酶反应生成的,在各种生物系统中参与细胞增殖和分化。(S)-Coriolic acid 在 1 μM 左右时,它能抑制肿瘤细胞与血管内皮的粘附,能下调 IRGpIIb/IIIa 受体的表达。(S)-Cori...
T10719 CCT365623 hydrochloride
化合物 T10719
2126136-98-7 98%
TargetMol Chemical Structure CCT365623 hydrochloride
CCT365623 hydrochloride is an orally active inhibitor of lysyl oxidase (LOX) (IC50: 0.89 μM). It suppresses EGFR (pY1068) and AKT phosphorylation driven by EGF.
TN2688 2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone
2,3,4'-三羟基-3',5'-二甲氧基苯丙酮
33900-74-2 98%
TargetMol Chemical Structure 2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone
2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone 是一种天然产物,可从 Parinari hypochrysea (Chrysobalanaceae) 中提取得到。2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone 具有抗氧化活性且对脂...
T78820 5-LOX-IN-5
化合物 5-LOX-IN-5
98%
TargetMol Chemical Structure 5-LOX-IN-5
5-LOX-IN-5(Compound 29)作为一种5-LOX抑制剂,拥有56 nM的半抑制浓度(IC50)。它主要被应用于神经退行性疾病的研究领域。
T79158 H15-LOX-2 inhibitor 1
化合物 h15-LOX-2 inhibitor 1
478040-08-3 98%
TargetMol Chemical Structure h15-LOX-2 inhibitor 1
h15-LOX-2 inhibitor 1(Comp 105)是一种针对人上皮细胞15-lipoxygenase-2 (h15-LOX-2)的抑制剂,表现出0.34 μM的IC50值。
T79360 COX-2/15-LOX-IN-2
化合物 COX-2/15-LOX-IN-2
98%
TargetMol Chemical Structure COX-2/15-LOX-IN-2
COX-2/15-LOX-IN-2 作为一种效能高的双重抑制剂,对COX-2和15-LOX的IC50值分别为0.065 μM和1.86 μM,显示出显著的抗氧化活性。
T79361 COX-2/15-LOX-IN-3
化合物 COX-2/15-LOX-IN-3
98%
TargetMol Chemical Structure COX-2/15-LOX-IN-3
COX-2/15-LOX-IN-3 (compound 5k) 为COX-2/15-LOX的一种双重抑制剂,具有分别为0.075 μM和1.97 μM的IC50值。该化合物能显著抑制LPS诱导的细胞产生促炎细胞因子(IL-6, ROS和NO),表明其具备显著的抗炎活性。
T79362 COX-2/15-LOX-IN-4
化合物 COX-2/15-LOX-IN-4
98%
TargetMol Chemical Structure COX-2/15-LOX-IN-4
COX-2/15-LOX-IN-4(compound 5i)是一种针对COX-2和15-LOX的双重抑制剂,其IC50值分别为0.075 μM和1.97 μM。该化合物能有效地阻止LPS诱发的细胞内促炎细胞因子(IL-6, ROS)的产生,表现出明确的抗炎活性。
T80651 (-)-Bornyl ferulate
化合物 (-)-Bornyl ferulate
55511-07-4 98%
TargetMol Chemical Structure (-)-Bornyl ferulate
(-)-Bornyl ferulate,作为5-脂氧合酶和COX抑制剂,其IC50值分别为10.4 μM和12.0 μM。
T10151 5-Lipoxygenase-In-1
化合物 T10151
125235-15-6 98%
TargetMol Chemical Structure 5-Lipoxygenase-In-1
5-Lipoxygenase-In-1 (compound example 4.10) is a 5-Lipoxygenase inhibitor.
T11196 Enazadrem
依那扎群
107361-33-1 98%
TargetMol Chemical Structure Enazadrem
Enazadrem is a 5-lipoxygenase inhibitor with antiinflammatory activities.
TN1871 Ligustroside
女贞甙
35897-92-8 98%
TargetMol Chemical Structure Ligustroside
Ligustroside shows little antioxidant, and anti-inflammatory properties, it shows a significant inhibition effect on prostaglandin E2 (PGE2)-release. Ligustrosid...
TN5174 Trichosanatine
化合物 TN5174
169626-16-8 98%
TargetMol Chemical Structure Trichosanatine
Trichosanatine and squamosamide, as potential candidates as lead compounds for further study in drug development process with the PP2A- α protein. Trichosanatine...
TL0014 Pinusolide
化合物 TL0014
31685-80-0 98%
TargetMol Chemical Structure Pinusolide
Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
T10438 AZD 4407
化合物 T10438
166882-70-8 98%
TargetMol Chemical Structure AZD 4407
AZD 4407 is a potent inhibitor of 5-lipoxygenase.
TN4783 Picralinal
化合物 TN4783
20045-06-1 98%
TargetMol Chemical Structure Picralinal
Picralinal has anti-inflammatory and analgesic effects.
T4571 Balsalazide
巴柳氮
80573-04-2 98%
TargetMol Chemical Structure Balsalazide
Balsalazide (Balsalazido) 可通过调节IL-6/STAT3通路起抑癌作用,可用于治疗炎症性肠病。
TN5020 (+/-)-Sigmoidin A
化合物 TN5020
176046-04-1 98%
TargetMol Chemical Structure (+/-)-Sigmoidin A
Sigmoidin A has moderate antioxidant, antimicrobial and anti-inflammatory activity.
Bunaprolast
T17191
Bunaprolast (U66858) 是一种新型有效的白三烯 B4 (LTB4) 抑制剂。Bunaprolast 具有氧化降解活性,对脂氧合酶 (lipoxygenase)和 TXB2 释放具有抑制作用。
CJ-13,610
T27026
CJ-13,610 是一种具有口服活性的非氧化还原型 5-脂氧合酶 (5-LOX) 抑制剂。 CJ-13,610 抑制白三烯 B4 的生物合成并调节巨噬细胞中 IL-6 mRNA 的表达。
(S)-Coriolic acid
T37974
(S)-Coriolic acid (13(S)-HODE) 是一种重要的细胞内信号剂,是亚油酸与植物和哺乳动物脂氧合酶反应生成的,在各种生物系统中参与细胞增殖和分化。(S)-Coriolic acid 在 1 μM 左右时,它能抑制肿瘤细胞与血管内皮的粘附,能下调 IRGpIIb/IIIa 受体的表达。(S)-Cori...
CCT365623 hydrochloride
T10719
CCT365623 hydrochloride is an orally active inhibitor of lysyl oxidase (LOX) (IC50: 0.89 μM). It suppresses EGFR (pY1068) and AKT phosphorylation driven by EGF.
2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone
TN2688
2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone 是一种天然产物,可从 Parinari hypochrysea (Chrysobalanaceae) 中提取得到。2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone 具有抗氧化活性且对脂...
5-LOX-IN-5
T78820
5-LOX-IN-5(Compound 29)作为一种5-LOX抑制剂,拥有56 nM的半抑制浓度(IC50)。它主要被应用于神经退行性疾病的研究领域。
h15-LOX-2 inhibitor 1
T79158
h15-LOX-2 inhibitor 1(Comp 105)是一种针对人上皮细胞15-lipoxygenase-2 (h15-LOX-2)的抑制剂,表现出0.34 μM的IC50值。
COX-2/15-LOX-IN-2
T79360
COX-2/15-LOX-IN-2 作为一种效能高的双重抑制剂,对COX-2和15-LOX的IC50值分别为0.065 μM和1.86 μM,显示出显著的抗氧化活性。
COX-2/15-LOX-IN-3
T79361
COX-2/15-LOX-IN-3 (compound 5k) 为COX-2/15-LOX的一种双重抑制剂,具有分别为0.075 μM和1.97 μM的IC50值。该化合物能显著抑制LPS诱导的细胞产生促炎细胞因子(IL-6, ROS和NO),表明其具备显著的抗炎活性。
COX-2/15-LOX-IN-4
T79362
COX-2/15-LOX-IN-4(compound 5i)是一种针对COX-2和15-LOX的双重抑制剂,其IC50值分别为0.075 μM和1.97 μM。该化合物能有效地阻止LPS诱发的细胞内促炎细胞因子(IL-6, ROS)的产生,表现出明确的抗炎活性。
(-)-Bornyl ferulate
T80651
(-)-Bornyl ferulate,作为5-脂氧合酶和COX抑制剂,其IC50值分别为10.4 μM和12.0 μM。
5-Lipoxygenase-In-1
T10151
5-Lipoxygenase-In-1 (compound example 4.10) is a 5-Lipoxygenase inhibitor.
Enazadrem
T11196
Enazadrem is a 5-lipoxygenase inhibitor with antiinflammatory activities.
Ligustroside
TN1871
Ligustroside shows little antioxidant, and anti-inflammatory properties, it shows a significant inhibition effect on prostaglandin E2 (PGE2)-release. Ligustrosid...
Trichosanatine
TN5174
Trichosanatine and squamosamide, as potential candidates as lead compounds for further study in drug development process with the PP2A- α protein. Trichosanatine...
Pinusolide
TL0014
Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
AZD 4407
T10438
AZD 4407 is a potent inhibitor of 5-lipoxygenase.
Picralinal
TN4783
Picralinal has anti-inflammatory and analgesic effects.
Balsalazide
T4571
Balsalazide (Balsalazido) 可通过调节IL-6/STAT3通路起抑癌作用,可用于治疗炎症性肠病。
(+/-)-Sigmoidin A
TN5020
Sigmoidin A has moderate antioxidant, antimicrobial and anti-inflammatory activity.
1 2 3 4 5 6
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