Lipoxygenase

Lipoxygenases are a family of (non-heme) iron-containing enzymes most of which catalyze the dioxygenation of polyunsaturated fatty acids in lipids containing a cis,cis-1,4- pentadiene into cell signaling agents that serve diverse roles as autocrine signals that regulate the function of their parent cells, paracrine signals that regulate the function of nearby cells, and endocrine signals that regulate the function of distant cells.The lipoxygenases are related to each other based upon their similar genetic structure and dioxygenation activity. However, one lipoxygenase, ALOXE3, while having a lipoxygenase genetic structure, possesses relatively little dioxygenation activity; rather its primary activity appears to be as an isomerase that catalyzes the conversion of hydroperoxy unsaturated fatty acids to their 1,5-epoxide, hydroxyl derivatives.

Cat. No.	Product Name	CAS No.	Purity
T27026	CJ-13,610 化合物CJ-13,610	179420-17-8	99.64%
T27026	CJ-13,610 是一种具有口服活性的非氧化还原型 5-脂氧合酶 (5-LOX) 抑制剂。 CJ-13,610 抑制白三烯 B4 的生物合成并调节巨噬细胞中 IL-6 mRNA 的表达。
T3090	Abietic Acid 松香酸	514-10-3	92.6%
T3090	Abietic Acid (Sylvic acid) 是从 Pimenta racemosavar. grissea 中提取出来的一种二萜，具有抗菌、抗增殖和抗肥胖的活性。它抑制脂氧合酶活性，可研究过敏性疾病。
T10719	CCT365623 hydrochloride 化合物 T10719	2126136-98-7	98%
T10719	CCT365623 hydrochloride is an orally active inhibitor of lysyl oxidase (LOX) (IC50: 0.89 μM). It suppresses EGFR (pY1068) and AKT phosphorylation driven by EGF.
TN2688	2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone 2,3,4'-三羟基-3',5'-二甲氧基苯丙酮	33900-74-2	98%
TN2688	2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone 是一种天然产物，可从 Parinari hypochrysea (Chrysobalanaceae) 中提取得到。2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone 具有抗氧化活性且对脂...
T78820	5-LOX-IN-5 化合物 5-LOX-IN-5		98%
T78820	5-LOX-IN-5（Compound 29）作为一种5-LOX抑制剂，拥有56 nM的半抑制浓度（IC50）。它主要被应用于神经退行性疾病的研究领域。
T79158	H15-LOX-2 inhibitor 1 化合物 h15-LOX-2 inhibitor 1	478040-08-3	98%
T79158	h15-LOX-2 inhibitor 1（Comp 105）是一种针对人上皮细胞15-lipoxygenase-2 (h15-LOX-2)的抑制剂，表现出0.34 μM的IC50值。
T79360	COX-2/15-LOX-IN-2 化合物 COX-2/15-LOX-IN-2		98%
T79360	COX-2/15-LOX-IN-2 作为一种效能高的双重抑制剂，对COX-2和15-LOX的IC50值分别为0.065 μM和1.86 μM，显示出显著的抗氧化活性。
T79361	COX-2/15-LOX-IN-3 化合物 COX-2/15-LOX-IN-3		98%
T79361	COX-2/15-LOX-IN-3 (compound 5k) 为COX-2/15-LOX的一种双重抑制剂，具有分别为0.075 μM和1.97 μM的IC50值。该化合物能显著抑制LPS诱导的细胞产生促炎细胞因子（IL-6, ROS和NO），表明其具备显著的抗炎活性。
T79362	COX-2/15-LOX-IN-4 化合物 COX-2/15-LOX-IN-4		98%
T79362	COX-2/15-LOX-IN-4（compound 5i）是一种针对COX-2和15-LOX的双重抑制剂，其IC50值分别为0.075 μM和1.97 μM。该化合物能有效地阻止LPS诱发的细胞内促炎细胞因子（IL-6, ROS）的产生，表现出明确的抗炎活性。
T80651	(-)-Bornyl ferulate 化合物 (-)-Bornyl ferulate	55511-07-4	98%
T80651	(-)-Bornyl ferulate，作为5-脂氧合酶和COX抑制剂，其IC50值分别为10.4 μM和12.0 μM。
T10151	5-Lipoxygenase-In-1 化合物 T10151	125235-15-6	98%
T10151	5-Lipoxygenase-In-1 (compound example 4.10) is a 5-Lipoxygenase inhibitor.
T11196	Enazadrem 依那扎群	107361-33-1	98%
T11196	Enazadrem is a 5-lipoxygenase inhibitor with antiinflammatory activities.
TN1871	Ligustroside 女贞甙	35897-92-8	98%
TN1871	Ligustroside shows little antioxidant, and anti-inflammatory properties, it shows a significant inhibition effect on prostaglandin E2 (PGE2)-release. Ligustrosid...
TN5174	Trichosanatine 化合物 TN5174	169626-16-8	98%
TN5174	Trichosanatine and squamosamide, as potential candidates as lead compounds for further study in drug development process with the PP2A- α protein. Trichosanatine...
TL0014	Pinusolide 化合物 TL0014	31685-80-0	98%
TL0014	Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
T10438	AZD 4407 化合物 T10438	166882-70-8	98%
T10438	AZD 4407 is a potent inhibitor of 5-lipoxygenase.
TN4783	Picralinal 化合物 TN4783	20045-06-1	98%
TN4783	Picralinal has anti-inflammatory and analgesic effects.
T4571	Balsalazide 巴柳氮	80573-04-2	98%
T4571	Balsalazide (Balsalazido) 可通过调节IL-6/STAT3通路起抑癌作用，可用于治疗炎症性肠病。
TN5020	(+/-)-Sigmoidin A 化合物 TN5020	176046-04-1	98%
TN5020	Sigmoidin A has moderate antioxidant, antimicrobial and anti-inflammatory activity.
T67870	DKI5 化合物DKI5	1101130-96-4	98%
T67870	DKI5 ((E)-N'-benzylidenehydrazinecarbothiohydrazide) 是一种 LOX-1 抑制剂，IC50 值为 22.5 μM。DKI5 可能具有抗炎和抗氧化活性，在体外生物测定中显示出抗脂质过氧化活性。