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Croconazole

Name: Croconazole
Brand: TargetMol
SKU: T9878
Price: 363 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 氯康唑

货号 T9878Cas号 77175-51-0 一键复制产品信息纯度: 99.71%

很棒

Croconazole 对中性粒细胞的 5-脂氧合酶 (5-LOX) 表现出剂量依赖性抑制活性。Croconazole 是一种抗真菌剂。Croconazole 对合成白三烯 B4 (LTB4) 和 5-羟基二十碳四烯酸 (5-HETE) 的 IC50 分别为 7.8 ± 1.7 和 7.6 ± 0.3 μM。

Croconazole

一键复制产品信息

很棒

纯度: 99.71%

货号 T9878Cas号 77175-51-0

别名 氯康唑

为众多的药物研发团队赋能，

让新药发现更简单！

规格	价格	库存
1 mg	¥ 363	现货
5 mg	¥ 728	现货
10 mg	¥ 978	现货
25 mg	¥ 1,670	现货
50 mg	¥ 2,460	现货
100 mg	¥ 3,660	现货
500 mg	¥ 8,180	现货
1 mL x 10 mM (in DMSO)	¥ 619	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

该分子属于定制产品。TargetMol拥有优秀的合成团队，经验和能力，可以为您提供高性价比的产品。如您有任何问题，欢迎咨询，我们将竭诚为您服务。

实验操作小课堂

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纯度: 99.71%

资源下载: COA HNMR LCMS产品操作手册

产品介绍

Croconazole AI Summary

Croconazole exhibits broad-spectrum bioactivity, notably with antifungal properties, antiviral effects against SARS-CoV-2, antitrypanosomal activity, and inhibitory actions on various human enzymes and receptors. It demonstrates antifungal activity with minimum inhibitory concentrations (MIC) of 3.1 ug.mL-1 against both Candida albicans and Aspergillus fumigatus, and a stronger activity against Trichophyton asteroides with an MIC of 0.1 ug.mL-1. The compound shows potent antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity, achieving a 97.62% inhibition rate at a 10 uM concentration after 48 hours, and an IC50 value of 18920.0 nM in Caco-2 cells, displaying moderate selectivity with a CC50 value of 33000.0 nM. It partially inhibits the SARS-CoV-2 3CL-Pro protease by 14.39% at 20 µM and also presents a negative inhibition percentage in VERO-6 cell assays. Croconazole displays antitrypanosomal activity against Trypanosoma cruzi Y, with IC50 values of 24,000.0 nM for the bloodstream form and 16,000.0 nM for trypomastigotes. Additionally, it inhibits human HDAC6 enzyme activity. Beyond these activities, it binds to various human and rat receptors and channels including KCNH2, Cacna1c, and others, contributing to a complex pharmacological profile..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Croconazole exhibited dose-dependent inhibitory activity on the 5-lipoxygenase (5-LOX) of neutrophils. Croconazole is an antimycotic agent. The IC50s for the synthesis of leukotriene B4 (LTB4) and 5-hydroxyeicosatetraenoic acid (5-HETE) is 7.8 +/- 1.7 and
别名	氯康唑

化学信息

分子量	310.78
分子式	C₁₈H₁₅ClN₂O
CAS No.	77175-51-0
Smiles	C(=C)(C1=C(OCC2=CC(Cl)=CC=C2)C=CC=C1)N3C=CN=C3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

Acetonitrile: 1.55 mg/mL (4.99 mM), Sonication is recommended.

Methanol: 1.55 mg/mL (4.99 mM), Sonication is recommended.

DMSO: 50 mg/mL (160.89 mM), Sonication is recommended.

溶液配制表

Acetonitrile/Methanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2177 mL	16.0886 mL	32.1771 mL	160.8855 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。