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Croconazole
一键复制产品信息
很棒纯度: 99.71%
货号 T9878Cas号 77175-51-0
别名 氯康唑
Croconazole 对中性粒细胞的 5-脂氧合酶 (5-LOX) 表现出剂量依赖性抑制活性。Croconazole 是一种抗真菌剂。Croconazole 对合成白三烯 B4 (LTB4) 和 5-羟基二十碳四烯酸 (5-HETE) 的 IC50 分别为 7.8 ± 1.7 和 7.6 ± 0.3 μM。
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Croconazole
一键复制产品信息 很棒纯度: 99.71%
货号 T9878 别名 氯康唑Cas号 77175-51-0
Croconazole 对中性粒细胞的 5-脂氧合酶 (5-LOX) 表现出剂量依赖性抑制活性。Croconazole 是一种抗真菌剂。Croconazole 对合成白三烯 B4 (LTB4) 和 5-羟基二十碳四烯酸 (5-HETE) 的 IC50 分别为 7.8 ± 1.7 和 7.6 ± 0.3 μM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 1 mg | ¥ 363 | 现货 | |
| 5 mg | ¥ 728 | 现货 | |
| 10 mg | ¥ 978 | 现货 | |
| 25 mg | ¥ 1,670 | 现货 | |
| 50 mg | ¥ 2,460 | 现货 | |
| 100 mg | ¥ 3,660 | 现货 | |
| 500 mg | ¥ 8,180 | 现货 | |
| 1 mL x 10 mM (in DMSO) | ¥ 619 | 现货 |
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产品介绍
Croconazole AI Summary
Croconazole exhibits broad-spectrum bioactivity, notably with antifungal properties, antiviral effects against SARS-CoV-2, antitrypanosomal activity, and inhibitory actions on various human enzymes and receptors. It demonstrates antifungal activity with minimum inhibitory concentrations (MIC) of 3.1 ug.mL-1 against both Candida albicans and Aspergillus fumigatus, and a stronger activity against Trichophyton asteroides with an MIC of 0.1 ug.mL-1. The compound shows potent antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity, achieving a 97.62% inhibition rate at a 10 uM concentration after 48 hours, and an IC50 value of 18920.0 nM in Caco-2 cells, displaying moderate selectivity with a CC50 value of 33000.0 nM. It partially inhibits the SARS-CoV-2 3CL-Pro protease by 14.39% at 20 µM and also presents a negative inhibition percentage in VERO-6 cell assays. Croconazole displays antitrypanosomal activity against Trypanosoma cruzi Y, with IC50 values of 24,000.0 nM for the bloodstream form and 16,000.0 nM for trypomastigotes. Additionally, it inhibits human HDAC6 enzyme activity. Beyond these activities, it binds to various human and rat receptors and channels including KCNH2, Cacna1c, and others, contributing to a complex pharmacological profile..
Note: Summary generated by AI. Data source: ChEMBL 
生物活性
化学信息
储存&溶解度
| 产品描述 | Croconazole exhibited dose-dependent inhibitory activity on the 5-lipoxygenase (5-LOX) of neutrophils. Croconazole is an antimycotic agent. The IC50s for the synthesis of leukotriene B4 (LTB4) and 5-hydroxyeicosatetraenoic acid (5-HETE) is 7.8 +/- 1.7 and |
| 别名 | 氯康唑 |
| 分子量 | 310.78 |
| 分子式 | C18H15ClN2O |
| CAS No. | 77175-51-0 |
| Smiles | C(=C)(C1=C(OCC2=CC(Cl)=CC=C2)C=CC=C1)N3C=CN=C3 |
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| 溶解度信息 | Acetonitrile: 1.55 mg/mL (4.99 mM), Sonication is recommended.  Methanol: 1.55 mg/mL (4.99 mM), Sonication is recommended. DMSO: 50 mg/mL (160.89 mM), Sonication is recommended. | ||||||||||
溶液配制表 | |||||||||||
Acetonitrile/Methanol/DMSO
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计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， 一共给药动物10只，您使用的配方为5%
DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。 以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
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