c-75

trans-C75 ((±)-C75) 是一种 C75 的对映异构体。其中 C75 是一种脂肪酸合成酶 (FASN) 的抑制剂。

C75 是一种合成脂肪酸合酶 (FASN) 抑制剂，可抑制前列腺癌细胞 PC3 (IC50: 35 μM)。C75 增加 CPT1 活性，降低 DIO。

Cis-C75是一种含有羧酸的五元氧杂环衍生物，可用于生物化学实验和药物合成研究。

SC-75416 是一种选择性COX-2抑制剂，可用于研究疼痛。

SP600125 (JNK Inhibitor II) 是一种 JNK 抑制剂，抑制 JNK1、JNK2 和 JNK3 (IC50=40/40/90 nM)，具有口服有效性、可逆性和 ATP 竞争性。SP600125 是一种有效的铁死亡抑制剂,可以抑制自噬，诱导凋亡。

Sulfinpyrazone (NSC-75925) 是一种口服有效的尿酸剂，具有抗血栓和血小板抑制作用。它可作用于慢性和间歇性痛风性关节炎。

Trifluridine (NSC-75520) 是一种氟化胸苷类似物，具有潜在的抗肿瘤活性，还具有抗病毒活性。它掺入 DNA 并抑制胸苷酸合酶，从而抑制 DNA 合成、抑制蛋白质合成和细胞凋亡。

LDC7559 通过在晚期阻断中性粒细胞胞外陷阱 (NET)来抑制gasdermin D (GSDMD)。

Odapipam is a selective and high affinity antagonist of benzazepine dopamine D1 receptor (Kd of 0.18 nM).

GANT 58 (NSC-75503) 是GLI 拮抗剂，能够抑制 GLI1 诱导的转录，其IC50=5 μM。

Pentaerythritol diacrolein acetal is an agent of biochemical.

NSC756093 可能抑制 GBP1:PIM1 相互作用。 NSC756093 可用于卵巢癌研究。

C.I. 62100 is a biochemical.

Purine (7H-Imidazo(4,5-d)pyrimidine) 是内源性代谢产物的一种。

SC75741 是NF-κB 抑制剂，对p65的IC50为 200 nM。它可阻断流感病毒复制。它通过损害NF-κB 亚基 p65 的 DNA 结合，导致细胞因子，趋化因子和促凋亡因子的表达降低，抑制 caspase 活化和阻断 caspase 介导的病毒核糖核蛋白的核输出。

Timelotem 是一种 1,2-并环1,4-苯二氮卓类药物，展现出明显的抗精神病特性。通过增强神经递质 γ-氨基丁酸 (GABA) 的作用，Timelotem 具有镇静、抗焦虑和抗惊厥等效果。Timelotem 可用于精神分裂症及其他精神障碍的研究。

Isoliquiritigenin (ISL) 属于黄酮类天然产物，抑制流感病毒复制 (EC50=24.7 μM)，也抑制 aldose reductase 的活性 (IC50=320 nM)。Isoliquiritigenin 具有抗肿瘤的活性。

(1,3-Dimethyl-1H-thieno[2,3-c]pyrazol-5-yl)methanol是一个片段分子，CAS号为423769-75-9，可作为分子拼接、扩展和修饰的重要骨架，为新型候选药物的设计与筛选提供结构基础与研究工具，常用于药物发现、药物合成等相关研究。

CHMFL-ABL/KIT-155 is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC50s: 46 nM/75 nM). It arrests cell cycle progression and induces apoptosis.

PPO-IN-17 (Compound 6R) 是一种原卟啉原 IX 氧化酶（PPO）抑制剂，其能够抑制烟草 PPO（NtPPO），Ki 为 30.34 nM。PPO-IN-17 展现除草效果，在浓度为 37.5 g/hm² 时，对稗草（E. crus-galli）、狐尾草（D. sanguinalis）、苜蓿（M. sativa）及加拿大苍耳（C. canadensis）的抑制率超过95%。该化合物对水稻（浓度为 75 g/hm²）和蜜蜂（浓度为 6400 mg/kg）无毒性。

STAT-3/c-Src-IN-1 (Compound 12d) 是一种双重抑制剂，靶向STAT-3 (IC50=0.844 μM) 和c-Src (IC50=0.268 μM)。它能够阻止肿瘤细胞的增殖、迁移和血管生成信号通路。该化合物对黑色素瘤 (SK-MEL-2) 和中枢神经系统癌症 (SNB-75) 细胞系显示出强效的抗增殖活性 (GI50=-5.75 μM 和 -5.63 μM)，通过诱导G0/G1和G2/M期细胞周期停滞，使肿瘤细胞凋亡。STAT-3/c-Src-IN-1 可能在黑色素瘤和胶质母细胞瘤的研究中具有应用潜力。

Masitinib (AB1010) 是生物口服可利用的选择性 c-Kit 抑制剂 (对于人重组c-Kit，IC50=200 nM)，它还抑制PDGFRα/β(IC50s=540/800 nM)，Lyn(对 LynB 的IC50=510 nM)，Lck，较小程度上抑制FGFR3和FAK。它有抗增殖，促凋亡活性，且毒性低。

Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs = 5-160 µg/ml) and Gram-negative bacteria (MICs = 136-200 µg/ml), as well as yeasts (MICs = 10-20 µg/ml).1Ajoene is cytotoxic to mouse melanoma cells (IC50= 18 µM), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 µM).2It reduces tumor growth in a B16/BL6 mouse model of melanoma when administered at a dose of 25 mg/kg every other day and decreases the number of lung metastases when administered prior to tumor cell inoculation at doses ranging from 1-25 mg/kg. It inhibits ADP- or collagen-induced platelet aggregation in isolated baboon platelets when used at concentrations ranging from 75 to 150 µg/ml and in platelet-rich plasma isolated from baboons when administered at a dose of 25 mg/kg.3Ajoene (25 mg/kg) prevents thrombus formation on damaged arterial walls in heparinized pigs in anin situmodel of thrombogenesis.5It also reduces high-fat diet-induced hepatic steatosis, histopathological markers of liver damage, thiobarbituric acid reactive substances (TBARS) formation, and protein oxidation in a mouse model of non-alcoholic fatty liver disease (NAFLD).4 1.Naganawa, R., Iwata, N., Ishikawa, K., et al.Inhibition of microbial growth by ajoene, a sulfur-containing compound derived from garlicAppl. Environ. Microbiol.62(11)4238-4242(1996) 2.Taylor, P., Noriega, R., Farah, C., et al.Ajoene inhibits both primary tumor growth and metastasis of B16/BL6 melanoma cells in C57BL/6 miceCancer Lett.239(2)298-304(2006) 3.Teranishi, K., Apitz-Castro, R., Robson, S.C., et al.Inhibition of baboon platelet aggregation in vitro and in vivo by the garlic derivative, ajoeneXenotransplantation10(4)374-379(2003) 4.Han, C.Y., Ki, S.H., Kim, Y.W., et al.Ajoene, a stable garlic by-product, inhibits high fat diet-induced hepatic steatosis and oxidative injury through LKB1-dependent AMPK activationAntioxid. Redox Signal.14(2)187-202(2011) 5.Apitz-Castro, R., Badimon, J.J., and Badimon, L.A garlic derivative, ajoene, inhibits platelet deposition on severely damaged vessel wall in an in vivo porcine experimental modelThromb. Res.75(3)243-249(1994)

AAA is an antagonist of G protein-coupled receptor 75 (GPR75).1It increases basal GPR75 protein levels and inhibits 20-HETE-induced reductions in GPR75 protein levels in PC3 cells. AAA (5 and 10 μM) also reduces 20-HETE-induced phosphorylation of EGFR, NF-κB, and Akt in, and cell migration of, PC3 cells.In vivo, AAA (10 mg/kg per day) reduces systolic blood pressure, albuminuria, renal angiotensin II levels, and cardiac hypertrophy in a Cyp1a1-Ren-2 transgenic rat model of malignant hypertension when administered prior to induction or after establishment of hypertension.2 1.Cárdenas, S., Colombero, C., Panelo, L., et al.GPR75 receptor mediates 20-HETE-signaling and metastatic features of androgen-insensitive prostate cancer cellsBiochim. Biophys. Acta Mol. Cell Biol. Lipids1865(2)158573(2020) 2.Sedláková, L., Kikerlová, S., Husková, Z., et al.20-Hydroxyeicosatetraenoic acid antagonist attenuates the development of malignant hypertension and reverses it once established: a study in Cyp1a1-Ren-2 transgenic ratsBiosci. Rep.38(5)BSR20171496(2018)