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Siglec-15 Protein, Human, Recombinant (hFc & Avi), Biotinylated

Siglec-15 Protein, Human, Recombinant (hFc & Avi), Biotinylated

产品编号 TMPJ-00217
别名: CD33L3, Siglec-15, Sialic acid-binding Ig-like lectin 15, CD33 antigen-like 3

Siglec-15 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Fc-Avi tag. The predicted molecular weight is 58-75 KDa and the accession number is Q6ZMC9.

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Siglec-15 Protein, Human, Recombinant (hFc & Avi), Biotinylated
规格 价格/CNY 货期 数量
20 μg ¥ 2,260 5日内发货
100 μg ¥ 6,130 5日内发货
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产品目录号及名称: Siglec-15 Protein, Human, Recombinant (hFc & Avi), Biotinylated (TMPJ-00217)
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生物活性
技术参数
产品性质
生物活性 Loaded Biotinylated Human Siglec-15-Fc(at#CY14) on AHC Biosensor, can bind Anti-Human Siglec15 mAb-mFc with an affinity constant of 0.13 nM as determined in BLI assay. (Regularly tested)
产品描述 Siglec-15 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Fc-Avi tag. The predicted molecular weight is 58-75 KDa and the accession number is Q6ZMC9.
种属 Human
表达系统 HEK293 Cells
标签 C-hFc-Avi
蛋白编号 Q6ZMC9
别名 CD33L3, Siglec-15, Sialic acid-binding Ig-like lectin 15, CD33 antigen-like 3
氨基酸序列 Phe20-Thr263
蛋白构建 Phe20-Thr263
蛋白纯度 Greater than 90% as determined by reducing SDS-PAGE. (QC verified)
分子量 58-75 KDa (reducing condition)
内毒素 < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, 150 mM NaCl, 0.3% Chaps, 5% Trehalose, pH 7.4.
复溶方法 Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglecs are type I transmembrane proteins where the NH3+-terminus is in the extracellular space and the COO−-terminus is cytosolic. Each Siglec contains an N-terminal V-type immunoglobulin domain (Ig domain) which acts as the binding receptor for sialic acid. These lectins are placed into the group of I-type lectins because the lectin domain is an immunoglobulin fold. All Siglecs are extended from the cell surface by C2-type Ig domains which have no binding activity. Siglecs differ in the number of these C2-type domains. Human Siglec-15 consists of a 244 amino acid (aa) extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 function is important for osteoclast formation and TRANCE/RANK Ligand signaling in osteoclasts.

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Keywords

Siglec-15 Protein, Human, Recombinant (hFc & Avi), Biotinylated CD33L3 Siglec-15 Sialic acid-binding Ig-like lectin 15 CD33 antigen-like 3 recombinant recombinant-proteins proteins protein

 

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