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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP2410 |
Sperm acrosomal peptide P23
Val-ala-lys-lys-pro-lys |
||
Sperm acrosomal peptide P23 is a peptide obtained from sperm acrosomal protein. | |||
T10904 |
CWP232228
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
CWP232228 是一种高效的、选择性的Wnt/β-catenin 信号通路抑制剂,在细胞核中,拮抗 β-catenin 与 T 细胞因子结合。它能够抑制乳腺癌和肝癌干细胞的生长,抑制肿瘤的形成和转移,且没有毒性。 | |||
T68455 |
AP23846
AP-23846 |
Src | Angiogenesis; Tyrosine Kinase/Adaptors |
AP23846 是一种新型高效的 Src 家族激酶抑制剂,可降低人实体瘤细胞系中血管内皮生长因子和白细胞介素-8 的表达,并消除下游血管生成过程。 | |||
T79705 |
LP23
|
PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation |
LP23为非芳基甲胺类PD-1/PD-L1抑制剂(IC50:16.7 nM),展现出抗肿瘤效果。能恢复HepG2/Jurkat T细胞的免疫功能并促进HepG2细胞凋亡。在B16-F10肿瘤模型中,LP23表现出体内活性,在剂量为30 mg/kg时TGI达到88.6%。 | |||
T68581 |
AP23464
|
||
AP23464 is a potent adenosine 5'-triphosphate (ATP)-based inhibitor of Src and Abl kinases, displays antiproliferative activity against a human CML cell line and Bcr-Abl-transduced Ba/F3 cells (IC(50) = 14 nM. AP23464 ablates Bcr-Abl tyrosine phosphorylation, blocks cell cycle progression, and promotes apoptosis of Bcr-Abl-expressing cells. Biochemical assays with purified glutathione S transferase (GST)-Abl kinase domain confirmed that AP23464 directly inhibits Abl activity. Importantly, the lo... | |||
T68607 | AP23848 | ||
AP23848 is a potent Bcr-Abl inhibitor. In a murine model, AP23848 inhibited activation-loop mutant Kit phosphorylation and tumor growth. | |||
T77094 | Navivumab | ||
Navivumab (CT-P23)是针对甲型流感病毒(influenza A virus) HA血凝素的单克隆抗体。该药物通过结合HA2蛋白的茎融合结构域,能中和H1、H2、H5及H9型甲型流感病毒。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-03509 |
TCTP/TPT1 Protein, Human, Recombinant (His)
tumor protein, translationally-controlled 1,HRF,TCTP,p23... |
Human | E. coli |
Tumor protein, also known as TPT1, is a highly conserved protein among many eukaryotic organisms. Tumor protein is involved in a variety of cellular activities, including microtubule stabilization, calcium-binding activities, and apoptosis. The Mammalian translationally controlled tumour protein (TPT1) (or P23) is a protein that has been found to be preferentially synthesised in cells during the early growth phase of some types of tumour, but which is also expressed in normal cells. It was first... | |||
TMPY-00499 |
TMP21 Protein, Human, Recombinant (mFc)
Tmp-21-I,p23,S31III125,TMP21,P24(DELTA),transmembra... |
Human | HEK293 |
TMED10 disrupts the complex formation between TGF-beta type I (also termed ALK5) and type II receptors (TbetaRII). Misexpression studies revealed that TMED10 attenuated TGF-beta-mediated signaling. A 20-amino acid-long region from Thr(91) to Glu(110) within the extracellular region of TMED10 was found to be crucial for TMED10 interaction with both ALK5 and TbetaRII. Synthetic peptides corresponding to this region inhibit both TGF-beta-induced Smad2 phosphorylation and Smad-dependent transcriptio... | |||
TMPH-00071 |
AtHsp23.6 Protein, Arabidopsis thaliana, Recombinant (His)
23.6 kDa heat shock protein, mitochondrial,AtHsp23.... |
Arabidopsis thaliana | E. coli |
AtHsp23.6 Protein, Arabidopsis thaliana, Recombinant (His) is expressed in E. coli with N-terminal 6xHis tag. The predicted molecular weight is 24.4 kDa. Accession number: Q96331 | |||
TMPJ-01256 |
Caspase-10 Protein, Human, Recombinant (His)
CASP10,FAS-Associated Death Domain Protein Interleukin-1B-Co... |
Human | E. coli |
Caspase-10 (CASP10) is a 521 amino acid protein member of the Cysteine-Aspartic Acid Protease (Caspase) family. CASP10 contains two DED (Death Effector) domains and is detectable in most tissues. CASP10 cleavage by Granzyme B and autocatalytic activity generate the two active subunits: Caspase-10 subunit p23/17, Caspase-10 subunit p12. Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the execution-phase of cell apoptosis, the initiation and execution. Human ca... |