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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-MED12/Trap230 Polyclonal Antibody

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货号 TMAB-08704

Anti-MED12/Trap230 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 MED12/Trap230。Anti-MED12/Trap230 Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-MED12/Trap230 Polyclonal Antibody

Anti-MED12/Trap230 Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-08704

Anti-MED12/Trap230 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 MED12/Trap230。Anti-MED12/Trap230 Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,170
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100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-MED12/Trap230 Polyclonal Antibody is a Rabbit antibody targeting MED12/Trap230. Anti-MED12/Trap230 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Mouse,Rat (predicted:Human,Pig,Cow,Rabbit,Sheep)
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus.
组织特异性Ubiquitous.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009]
抗原信息
免疫原
KLH conjugated synthetic peptide: human MED12/Trap230
抗原种属
Human
基因名称
MED12
基因ID
9968
蛋白名称
Mediator of RNA polymerase II transcription subunit 12
Uniprot ID
Q93074
功能
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.
化学信息
分子量Theoretical: 243 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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