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Search Results for " monomethyl "

60

抑制剂 & 化合物

11

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T6897	Monomethyl auristatin E 一甲基澳瑞他汀E,Vedotin,MMAE	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Monomethyl auristatin E (MMAE) 是海兔毒素 10 的合成衍生物，是一种抗有丝分裂剂，通过阻断微管蛋白的聚合来抑制细胞分裂，并且还具有抑制抗体-药物偶联物的活性。
T21236	Monomethyl sebacate Decanoic acid, monomethyl ester,Methyl hydrogen sebacate
	Monomethyl sebacate is a biochemical.
T19435	Monomethyl fumarate-d3 Monomethyl fumarate D3	Others	Others
	Monomethyl fumarate D3 is a deuterium labeled Monomethyl fumarate.
T12081	MMAF-OMe Monomethyl auristatin F methyl ester
	MMAF-OMe (Monomethyl auristatin F methyl ester) 是一种抗微管蛋白剂，能够抑制 MDAMB435/5T4，MDAMB361DYT2，MDAMB468 和 Raji (5T4-) 这四种肿瘤细胞，IC50值分别为 0.056 nM，0.166 nM，0.183 nM 和 0.449 nM。它也是ADC 细胞毒素。
T18143	m-PEG12-OH Dodecaethylene Glycol Monomethyl Ether	Others; PROTAC Linker	Others; PROTAC
	m-PEG12-OH (Dodecaethylene Glycol Monomethyl Ether) 是一种基于 PEG 的 PROTAC 接头，可用于 PROTAC 的合成。它也是一种不可切割的 12 单元 PEG ADC 接头，用于合成抗体-药物偶联物。
T3256	MMAF 一甲基澳瑞他汀 F,MonoMethyl auristatin F	Others; Microtubule Associated	Cytoskeletal Signaling; Others
	MMAF (MonoMethyl auristatin F) 是一种抗有丝分裂剂，通过阻断微管蛋白的聚合来抑制细胞分裂，用作抗肿瘤药物和抗体偶联药物的细胞毒性成分。
T4677	MMAD Monomethylauristatin D,Demethyldolastatin 10,单甲基澳瑞他汀 D,Monomethyl Dolastatin 10	Microtubule Associated	Cytoskeletal Signaling
	MMAD (Demethyldolastatin 10) 是一种有效的微管蛋白抑制剂，是抗体药物偶联物中的一种毒素有效载荷。
T39203	Raloxifene 6-Monomethyl Ether
	Compound 7, or Raloxifene 6-Monomethyl Ether, is a derivative of Raloxifene that effectively inhibits estrogen receptor α. It also displays the inhibitory effects on MCF-7 cells, with an IC50 of 250 nM and a pIC50 of 6.6.
T39298	Raloxifene 4-Monomethyl Ether
	Raloxifene 4-Monomethyl Ether (Compound 37) is a derivative of Raloxifene which acts as an inhibitor of estrogen receptor α. It effectively suppresses the activity of MCF-7 cells, exhibiting an IC50 value of 1 μM and a pIC50 value of 6.
T33475	Monomethyl adipate NSC55113,NSC 55113,NSC-55113
	Monomethyl adipate is a biochemical.
T38970	Hematoporphyrin monomethyl ether
	Hematoporphyrin monomethyl ether (HMME), a second-generation porphyrin-related photosensitizer, is a highly selective and low-toxicity compound known for its singular form and high yield of singlet oxygen. It finds extensive application in diagnosing and treating various tumors, including lung cancer, bladder cancer, nevus flammeus, and brain glioma.
T16467	Pentaethylene glycol monomethyl ether	Others	Others
	Pentaethylene glycol monomethyl ether (PEG-MME) is a PEG-based PROTAC linker, which is employed for the synthesis of PROTACs[1].
T15475	Hexaethylene glycol monomethyl ether	Others	Others
	Hexaethylene glycol monomethyl ether, a PEG-based PROTAC linker, facilitates the synthesis of PROTACs[1].
T17054	Tetraethylene glycol monomethyl ether	Others	Others
	Tetraethylene glycol monomethyl ether, a PEG-based PROTAC linker, is employed for the synthesis of PROTACs[1].
T16374	Octaethylene glycol monomethyl ether	Others	Others
	Octaethylene glycol monomethyl ether, a PEG-based linker, serves as an essential component in the synthesis of PROTACs[1].
T16336	Nonaethylene glycol monomethyl ether	Others	Others
	Nonaethylene glycol monomethyl ether, a PEG-based PROTAC linker, facilitates PROTAC synthesis[1].
T20988	Isopropylene glycol monomethyl ether acetate
	Isopropylene glycol monomethyl ether acetate is a bioactive chemical.
T18869	Vat-Cit-PAB-Monomethyl Dolastatin 10	Others	Others
	Vat-Cit-PAB-Monomethyl Dolastatin 10 is an ADC linker-conjugated drug designed to deliver potent antitumor activity. It achieves this through Monomethyl Dolastatin 10, a potent tubulin inhibitor, connected via the Vat-Cit-PAB ADC linker.
T15834	m-PEG10-alcohol Decaethylene glycol monomethyl ether	Others	Others
	m-PEG10-alcohol, also known as Decaethylene glycol monomethyl ether, is a non-cleavable 10 unit PEG ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs)[1]. Additionally, m-PEG10-alcohol serves as a PEG-based PROTAC linker, enabling its application in the synthesis of PROTACs[1].
T26277L	Tilarginine citrate L-Ng-monomethyl arginine citrate
	Tilarginine citrate is a competitive nitric oxide synthetase inhibitor.
T10948	MMAE-d8 D8-MMAE,D8-Monomethyl auristatin E	Others	Others
	D8-MMAE (D8-Monomethyl auristatin E) is an effective mitotic inhibitor and tubulin inhibitor, deuterated MMAE.
T24982	546C88 L-N(G)-Methylarginine hydrochloride,NG-Monomethyl-L-arginine hydrochloride,L-NMMA
	546C88 is an inhibitor of nitric oxide synthase.
T10947	D8-MMAD Monomethylauristatin D D8,Demethyldolastatin 10 D8,Monomethyl Dolastatin 10 D8	Others	Others
	D8-MMAD is a deuterated form of MMAD, which is a microtubule destroyer.
T71844	Methyl potassium malonate
	Methyl potassium malonate is a protein advanced glycosylation inhibitor.
T18312	Mc-MMAE Maleimidocaproyl-monomethylauristatin E,马来酰亚胺基己酰-单甲基澳瑞他汀 E	Microtubule Associated	Cytoskeletal Signaling
	Mc-MMAE (Maleimidocaproyl-monomethylauristatin E) 是保护基团 (马来酰亚氨基己酰) 与 MMAE 共轭连接得到的化合物。它是微管蛋白抑制剂，可用于偶联抗体。
T4271	Diroximel fumarate Diroximel Fumarete	Others	Others
	Diroximel fumarate (Diroximel Fumarete) 是一种控释制剂，是口服具有活力的富马酸单乙酯的前体药物。它被认为与其活性代谢物富马酸二甲酯的活性等效。它具有良好的安全性和有效性，具有研究多发性硬化的潜力。
T40568	Fmoc-MMAE
	Fmoc-MMAE, a protective group-conjugated variant of monomethyl auristatin E (MMAE), serves as a powerful inhibitor of tubulin. It finds application in the synthesis of antibody-drug conjugates (ADC).
T18679	SC-VC-PAB-MMAE	Others	Others
	SC-VC-PAB-MMAE is a potent antitumor drug-linker conjugate for antibody-drug conjugates (ADCs), comprising the anti-mitotic agent monomethyl auristatin E (MMAE, a tubulin inhibitor) connected through the cleavable linker SC-VC-PAB[1].
T39307	Azido-PEG4-Val-Cit-PAB-MMAE Azido-PEG4-Val-Cit-PAB-MMAE
	Azido-PEG4-Val-Cit-PAB-MMAE is a drug-linker conjugate for antibody-drug conjugates (ADCs), comprising the anti-mitotic agent monomethyl auristatin E (MMAE, a tubulin inhibitor), connected through the cleavable linker Azido-PEG4-Val-Cit-PAB-OH.
T18311	Mc-MMAD	Others	Others
	Mc-MMAD, a drug-linker conjugate for antibody-drug conjugates (ADCs), incorporates the protective group maleimidocaproyl (Mc) conjugated to monomethyl auristatin D (MMAD), a potent inhibitor of tubulin.
T18736	SuO-Val-Cit-PAB-MMAE	Others	Others
	SuO-Val-Cit-PAB-MMAE is an ADC (antibody-drug conjugate) linker comprising the anti-mitotic monomethyl auristatin E (MMAE, a tubulin inhibitor) connected through the SuO-Val-Cit-PAB peptide.
T17817	DBCO-(PEG)3-VC-PAB-MMAE	Others	Others
	DBCO-(PEG)3-VC-PAB-MMAE is a chemical compound where monomethyl auristatin E (MMAE), a potent tubulin inhibitor acting as a toxin payload in antibody-drug conjugates, is conjugated to a DBCO-(PEG)3-vc-PAB linker.
T70958	Dov-Val-Dil-OH TFA
	Dov-Val-Dil-OH is a useful chemical intermediate for synthesis of auristatin-related compounds, such as Monomethyl auristatin E (MMAE), Auristatins are antimitotic agents which inhibits cell division by blocking the polymerisation of tubulin.
T18251	MAL-di-EG-Val-Cit-PAB-MMAF	Others	Others
	MAL-di-EG-Val-Cit-PAB-MMAF refers to a chemical compound that comprises the linker (MAL-di-EG-Val-Cit-PAB) and the potent blocker of tubulin polymerization (MMAF, Monomethyl auristatin F)[1].
T77838	Telisotuzumab vedotin ABBV-399
	Telisotuzumab vedotin (ABBV-399) 是一种靶向c-Met的抗体-药物偶联物（ADCs），由Monomethyl Auristatin E (MMAE)、Telisotuzumab抗体和mc-val-cit-PABC可裂解型linker组合而成，主要用于癌症研究。
T18303	Mal-Phe-C4-VC-PAB-MMAE	Others	Others
	Mal-Phe-C4-VC-PAB-MMAE is a chemical compound resulting from the conjugation of monomethyl auristatin E (MMAE), a potent tubulin inhibitor serving as a toxin payload in antibody-drug conjugates, with a Mal-Phe-C4-VC-PAB linker.
T79039	GGGDTDTC-Mc-vc-PAB-MMAE
	GGGDTDTC-Mc-vc-PAB-MMAE为一种ADC药物-连接物偶联物，主要由微管蛋白抑制剂Monomethylauristatin E (MMAE)组成。
T81361	PSMA-Val-Cit-PAB-MMAE
	PSMA-Val-Cit-PAB-MMAE是一种靶向前列腺特异性膜抗原（PSMA）的小分子化合物，用MMAE作为药效基团进行前列腺癌治疗。
T82384	Fmoc-Gly3-VC-PAB-MMAE
	Fmoc-Gly3-VC-PAB-MMAE 是一款用于 ADC 的药物-连接子偶联物，由 MonomethylauristatinE 和连接子构成。
T77883	Val-Ala-PAB-MMAE
	Val-Ala-PAB-MMAE是一种用于抗体药物偶联物(ADC)的药物连接物缀合物，由ADC连接子(Val-Ala-PAB)与微管抑制剂MMAE构成。
T82380	Fmoc-VAP-MMAE
	Fmoc-VAP-MMAE是一种含有微管蛋白抑制剂MMAE的ADC活性分子-linker偶联物，配备了Fmoc保护基团。该复合物由ADC Linker和MMAE构成。
T81133	Sofituzumab vedotin DMUC5754A
	Sofituzumab vedotin (DMUC5754A) 是一种抗MUC16的ADC，其含有MMAE并配备蛋白酶切割连接子。该化合物主要应用于癌症研究领域。
T15872	m-PEG4-Br	Others	Others
	m-PEG4-Br is a cleavable ADC linker used in the synthesis of antibody-drug conjugate (ADC) for Trastuzumab. m-PEG4-Br is placed distally from the monomethyl auristatin E (MMAE) payload to yield an ADC with altered hydrophilicity, antigen binding, and in v
T18473	N3-PEG3-vc-PAB-MMAE	Others	Others
	N3-PEG3-vc-PAB-MMAE, a drug-linker conjugate designed for Antibody-Drug Conjugates (ADC), features the integration of monomethyl auristatin E (MMAE), a tubulin inhibitor, via a 3-unit polyethylene glycol (PEG) linker. This compound demonstrates significant antitumor activity.
T18326	MC-Val-Cit-PAB-MMAF	Others	Others
	MC-Val-Cit-PAB-MMAF is an antibody-drug conjugate (ADC) component that exhibits antitumor properties through the action of the tubulin inhibitor, monomethyl auristatin F (MMAF), which is connected by a cathepsin-cleavable linker, MC-Val-Cit-PAB.
T77892	Mal-PEG8-Val-Cit-PAB-MMAF
	Mal-PEG8-Val-Cit-PAB-MMAF 是一种用于抗体药物偶联体 (ADC) 的药物-连接物复合体 (drug-linker conjugate for ADC)。该化合物由一个可降解的 ADC linker 以及有效的微管蛋白抑制剂 MMAE 组成。
T81753	mp-dLAE-PABC-MMAE
	mp-dLAE-PABC-MMAE 是构成抗体药物偶联物 (ADC) 活性部分的化合物。它包括微管蛋白抑制剂 Monomethylauristatin E，并用于ADC的合成。
T27975	MAL-PEG4-MMAF
	MAL-PEG4-MMAF is a maleimido functionalized derivative of MMAF (Monomethyl auristatin F) with PEG4 linker. The maleimido functional group can be easily conjugated to protein carriers (such as antibody or enzyme). MAL-PEG4-MMAF is a useful precursor for ma
T17789	DBCO-(PEG2-VC-PAB-MMAE)2	Others	Others
	DBCO-(PEG2-VC-PAB-MMAE)2 consists of Monomethyl auristatin E (MMAE), a toxin payload in antibody-drug conjugate [1], conjugated to the cleavable linker DBCO-(PEG2-VC-PAB)2. MMAE, a potent tubulin inhibitor, serves as the cytotoxic component in this formulation.
T71768	CB10-277
	CB10-277 is a synthetic derivative of dimethylphenyl-triazene related to dacarbazine, with antineoplastic properties. Related to the agent dacarbazine, CB10-277 is converted in vivo to a monomethyl triazene form that alkylates DNA, resulting in inhibition of DNA replication and repair; in addition, this agent may act as a purine analogue, resulting in inhibition of DNA synthesis, and may interact with protein sulfhydryl groups.

化合物

Monomethyl auristatin E

Cat.No: T6897

Synonym: 一甲基澳瑞他汀E,Vedotin,MMAE

Target: Apoptosis, Microtubule Associated

Monomethyl sebacate

Cat.No: T21236

Synonym: Decanoic acid, monomethyl ester,Methyl hydrogen sebacate

Monomethyl fumarate-d3

Cat.No: T19435

Synonym: Monomethyl fumarate D3

Target: Others

Cat.No: T12081

Synonym: Monomethyl auristatin F methyl ester

Cat.No: T18143

Synonym: Dodecaethylene Glycol Monomethyl Ether

Target: Others, PROTAC Linker

Cat.No: T3256

Synonym: 一甲基澳瑞他汀 F,MonoMethyl auristatin F

Target: Others, Microtubule Associated

Cat.No: T4677

Synonym: Monomethylauristatin D,Demethyldolastatin 10,单甲基澳瑞他汀 D,Monomethyl Dolastatin 10

Target: Microtubule Associated

Raloxifene 6-Monomethyl Ether

Cat.No: T39203

Raloxifene 4-Monomethyl Ether

Cat.No: T39298

Monomethyl adipate

Cat.No: T33475

Synonym: NSC55113,NSC 55113,NSC-55113

Hematoporphyrin monomethyl ether

Cat.No: T38970

Pentaethylene glycol monomethyl ether

Cat.No: T16467

Target: Others

Hexaethylene glycol monomethyl ether

Cat.No: T15475

Target: Others

Tetraethylene glycol monomethyl ether

Cat.No: T17054

Target: Others

Octaethylene glycol monomethyl ether

Cat.No: T16374

Target: Others

Nonaethylene glycol monomethyl ether

Cat.No: T16336

Target: Others

Isopropylene glycol monomethyl ether acetate

Cat.No: T20988

Vat-Cit-PAB-Monomethyl Dolastatin 10

Cat.No: T18869

Target: Others

m-PEG10-alcohol

Cat.No: T15834

Synonym: Decaethylene glycol monomethyl ether

Target: Others

Tilarginine citrate

Cat.No: T26277L

Synonym: L-Ng-monomethyl arginine citrate

Cat.No: T10948

Synonym: D8-MMAE,D8-Monomethyl auristatin E

Target: Others

Cat.No: T24982

Synonym: L-N(G)-Methylarginine hydrochloride,NG-Monomethyl-L-arginine hydrochloride,L-NMMA

Cat.No: T10947

Synonym: Monomethylauristatin D D8,Demethyldolastatin 10 D8,Monomethyl Dolastatin 10 D8

Target: Others

Methyl potassium malonate

Cat.No: T71844

Cat.No: T18312

Synonym: Maleimidocaproyl-monomethylauristatin E,马来酰亚胺基己酰-单甲基澳瑞他汀 E

Target: Microtubule Associated

Diroximel fumarate

Cat.No: T4271

Synonym: Diroximel Fumarete

Target: Others

Cat.No: T40568

Cat.No: T18679

Target: Others

Azido-PEG4-Val-Cit-PAB-MMAE

Cat.No: T39307

Synonym: Azido-PEG4-Val-Cit-PAB-MMAE

Cat.No: T18311

Target: Others

SuO-Val-Cit-PAB-MMAE

Cat.No: T18736

Target: Others

DBCO-(PEG)3-VC-PAB-MMAE

Cat.No: T17817

Target: Others

Dov-Val-Dil-OH TFA

Cat.No: T70958

MAL-di-EG-Val-Cit-PAB-MMAF

Cat.No: T18251

Target: Others

Telisotuzumab vedotin

Cat.No: T77838

Synonym: ABBV-399

Mal-Phe-C4-VC-PAB-MMAE

Cat.No: T18303

Target: Others

GGGDTDTC-Mc-vc-PAB-MMAE

Cat.No: T79039

PSMA-Val-Cit-PAB-MMAE

Cat.No: T81361

Fmoc-Gly3-VC-PAB-MMAE

Cat.No: T82384

Val-Ala-PAB-MMAE

Cat.No: T77883

Cat.No: T82380

Sofituzumab vedotin

Cat.No: T81133

Synonym: DMUC5754A

Cat.No: T15872

Target: Others

N3-PEG3-vc-PAB-MMAE

Cat.No: T18473

Target: Others

MC-Val-Cit-PAB-MMAF

Cat.No: T18326

Target: Others

Mal-PEG8-Val-Cit-PAB-MMAF

Cat.No: T77892

mp-dLAE-PABC-MMAE

Cat.No: T81753

Cat.No: T27975

DBCO-(PEG2-VC-PAB-MMAE)2

Cat.No: T17789

Target: Others

Cat.No: T71768

Cat. No.	Product Name	Target	Signaling Pathways
T12095	Monomethyl fumarate	GPR; Drug Metabolite	Endocrinology/Hormones; GPCR/G Protein; Metabolism
	Monomethyl fumarate 是 Dimethyl fumarate 的活性代谢产物。Monomethyl fumarate 是一种 GPR109A 激动剂。Monomethyl fumarate 是一种 GPR109A 激动剂具有用于多种神经保护途径和其他视网膜疾病模型的潜力。
TN3323	Monomethyl lithospermate Lithospermic acid monomethyl ester	Akt; PI3K	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Monomethyl lithospermate (Lithospermic acid monomethyl ester) 具有潜在的抗病毒活性，通过激活PI5K/Akt信号传导，减轻体内大脑中动脉闭塞小鼠缺血性中风损伤，并在体外保护氧葡萄糖剥夺/复氧诱导的SHSY-3Y细胞。Monomethyl lithospermate 能提高 SHSY-5Y 细胞的生存能力，抑制线粒体膜电位 (MMOP) 崩溃，抑制细胞凋亡。Monomethyl lithospermate 还降低中动脉闭塞 (MCAO) 大鼠脑组织中的氧化应激水平，改善缺血性中风 (IS) 大鼠神经损伤。
TN4578	Monomethyl kolavate	Antifection	Microbiology/Virology
	Monomethyl kolavate is a power Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) inhibitor, with an IC50 value of 12uM.
TN4393	Koaburaside monomethyl ether	Others	Others
	Koaburaside monomethyl ether是一种天然产物，属于大戟科巴豆属，其产品编号为 TN4393，CAS号为 41514-64-1。Koaburaside monomethyl ether可用作对照参考。
TN4169	Grifolin monomethyl ether	Others	Others
	Grifolin monomethyl ether 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN4169，CAS号为 64432-04-8。
T20793	Magnesium Lithospermate B 丹參酸B鎂,Monomethyl lithospermate B,丹参酸 B 镁,Lithospermate B	Others	Others
	Magnesium Lithospermate B 是一种咖啡酸四聚体的衍生物，从Salviae miltiorrhizae 中提取得到。它能够抑制神经炎症并减轻神经变性。它被广泛用于心血管疾病的研究，并且可以防止葡萄糖引起的细胞内氧化损伤。
TN3907	Pinosylvin monomethyl ether (E)-3-Hydroxy-5-methoxystilbene	Antifection	Microbiology/Virology
	(E)-3-Hydroxy-5-methoxystilbene possesses inhibitory activity against several Gram-positive bacteria, including isolates of methicillin-resistant Staphylococcus aureus (MRSA), Mycobacterium bovis BCG, and avirulent Bacillusanthracis (Sterne strain), among
TN6976	(+)-Pinoresinol monomethyl ether 4-O-β-D-glucoside
	(+)-Pinoresinol monomethyl ether 4-O-β-D-glucoside is a natural product.
TN3403	Djalonensone 交链孢霉甲基醚,Alternariol monomethyl ether	Immunology/Inflammation related	Immunology/Inflammation
	Djalonensone (Alternariol monomethyl ether) 具有强大的 DPPH 自由基清除作用。
TN4579	Monomethylsulochrin	Antifection	Microbiology/Virology
	Monomethylsulochrin shows antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus. It shows moderately inhibitory effects on the human bacterial pathogen Helicobacter pylori with the MIC value of 28.9+/-0.1 microM.
T4764	5-Methoxy-5-oxopentanoic acid 戊二酸单乙酯,mono-Methyl glutarate,METHYL HYDROGEN GLUTARATE	Others; Endogenous Metabolite	Metabolism; Others
	5-Methoxy-5-oxopentanoic acid (mono-Methyl glutarate) 是内源性代谢产物的一种。

天然产物

Monomethyl fumarate

Cat.No: T12095

Target: GPR, Drug Metabolite

Monomethyl lithospermate

Cat.No: TN3323

Synonym: Lithospermic acid monomethyl ester

Target: Akt, PI3K

Monomethyl kolavate

Cat.No: TN4578

Target: Antifection

Koaburaside monomethyl ether

Cat.No: TN4393

Target: Others

Grifolin monomethyl ether

Cat.No: TN4169

Target: Others

Magnesium Lithospermate B

Cat.No: T20793

Synonym: 丹參酸B鎂,Monomethyl lithospermate B,丹参酸 B 镁,Lithospermate B

Target: Others

Pinosylvin monomethyl ether

Cat.No: TN3907

Synonym: (E)-3-Hydroxy-5-methoxystilbene

Target: Antifection

(+)-Pinoresinol monomethyl ether 4-O-β-D-glucoside

Cat.No: TN6976

Cat.No: TN3403

Synonym: 交链孢霉甲基醚,Alternariol monomethyl ether

Target: Immunology/Inflammation related

Monomethylsulochrin

Cat.No: TN4579

Target: Antifection

5-Methoxy-5-oxopentanoic acid

Cat.No: T4764

Synonym: 戊二酸单乙酯,mono-Methyl glutarate,METHYL HYDROGEN GLUTARATE

Target: Others, Endogenous Metabolite

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