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Targets Recommended: Akt

48

抑制剂 & 化合物

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重组蛋白

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Cat. No. Product Name
L2191 抗乳腺癌化合物库

1965 compounds
1965 种与乳腺癌相关的化合物,可以用于抗乳腺癌药物研发和药理研究;

化合物库

抗乳腺癌化合物库
Cat.No: L2191
Compounds: 1965
Cat. No. Product Name Target Signaling Pathways
T10274 AKT-IN-2

Akt Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
AKT-IN-2 is a selective, and orally bioavailable AKT inhibitor (IC50: 5 nM for AKT1).
T60564 PI3K/Akt/mTOR-IN-2

Apoptosis; Akt; PI3K; mTOR Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
PI3K/Akt/mTOR-IN-2 是一种有效的 PI3K/AKT/mTOR 抑制剂。PI3K/Akt/mTOR-IN-2 具有抗癌作用,并对 MDA-MB-231 细胞具有选择性,IC50 为 2.29 μM。PI3K/Akt/mTOR-IN-2 具有抗癌活性,可诱导癌细胞周期阻滞和细胞凋亡 (apoptosis)。
T72880 PI3K/AKT-IN-2

PI3K/AKT-IN-2 是一种 PI3K 和 AKT 抑制剂。PI3K/AKT-IN-2 阻断上皮-间质转化 (EMT),诱导细胞凋亡 (apoptosis)。PI3K/AKT-IN-2 抑制微管蛋白 (tubulin) 的聚合。
T36310 AKT-IN-6

INCB-047775

Akt Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
AKT-IN-6 (INCB-047775)对ATK 有抑制作用。Akt 是对生长因子、细胞因子和其他细胞刺激的细胞信号传导的重要组成部分。Akt 的异常激活与2型糖尿病和癌症的发生密切相关。
T39988 6'-GNTI dihydrochloride

Opioid Receptor; Akt Cytoskeletal Signaling; Endocrinology/Hormones; GPCR/G Protein; Neuroscience; PI3K/Akt/mTOR signaling
6'-GNTI dihydrochloride 是一种κ-阿片受体(KOR)激动剂,它偏向于激活 G 蛋白介导的信号传导,而不是β-阿司匹林2的募集。6'-GNTI dihydrochloride 只能激活纹状体神经元中的 Akt 通路。
T72968 ZINC00640089

Akt Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
ZINC00640089 是一种选择性的脂质运载蛋白-2 (LCN2) 抑制剂。ZINC00640089 对细胞增殖、细胞活力有抑制作用,可减少 SUM149 细胞的 AKT 磷酸化水平。ZINC00640089 可用于研究炎症性乳腺癌 (IBC) 。
T8656 CAY10404

3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T

Apoptosis; Akt; COX Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; Neuroscience; PI3K/Akt/mTOR signaling
CAY10404 (3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T) 是一种有效且高度选择性的 COX-2 和 COX-1 抑制剂。 它还是 PKB/Akt 和 MAPK 信号通路的有效抑制剂,可诱导 NSC-LC 细胞凋亡,具有镇痛、抗炎和抗癌活性。
T50107 ethyl 2-[3,5-bis(trifluoromethyl)phenyl]-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate

Others Others
ethyl 2-[3,5-bis(trifluoromethyl)phenyl]-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate 是一种合成化合物,属于姜黄素家族。它通过抑制NF-κB 信号通路参与免疫反应和炎症的调节,通过激活Nrf2信号通路参与抗氧化反应的调节,通过抑制Akt 信号通路参与细胞存活和增殖的调节。
T14214 AMG 511

PI3K PI3K/Akt/mTOR signaling
AMG 511 是一种高效的、口服有效的 I 类 pan-PI3K 抑制剂,对 PI3Kα, β, δ 和 γ 作用的 Ki 值分别为 4 nM, 6 nM, 2 nM 和 1 nM。它它显著抑制了 PI3K 信号,减少 p-Akt (Ser473)。它在小鼠胶质母细胞瘤移植瘤模型中具有抗肿瘤作用。
T4444 A-674563 HCl (552325-73-2(free base))

ERK; Akt; PKA; CDK; PKC Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
A-674563 HCl (552325-73-2(free base)) 是一种口服的、ATP 竞争性的、可逆的 Akt 抑制剂(Akt1 的 Ki:11 nM)。它对 PKA 和 Cdk2 具有抑制活性(IC50:16/46 nM),但对 Akt1 的选择性比 CMGC、CAMK 和 TK 家族中的其他激酶高 10 至 >1800 倍。
T3211 Midostaurin

米哚妥林,N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251,苯甲酰基十字孢碱

Others; PKC Chromatin/Epigenetic; Cytoskeletal Signaling; Others
Midostaurin (PKC412) 是一种多靶点蛋白激酶抑制剂,有抗肿瘤活性,对 PKCα/β/γ、Syk、Flk-1、Akt、PKA、c-Kit、c-Fgr、c-Src、FLT3、PDFRβ和VEGFR1/2的IC50值范围为 22 到500 nM 之间。
T72885 Akt1&PKA-IN-1

Akt1&PKA-IN-1 是一种有效的Akt/PKA 双重抑制剂,对 PKAa、Akt 和CDK2的IC50值分别为 0.03、0.11 μM 和 9.8 μM。Akt1&PKA-IN-1 对细胞周期蛋白依赖性激酶 2 (CDK2) 具有选择性。
T35489 1-O-Octadecyl-2-O-methyl-sn-glycerol

1-O-Octadecyl-2-O-methyl-sn-glycerol is a metabolite of a phosphotidylinositol ether lipid analog (PIA). PIAs are known to target the pleckstrin homology domain of the serine/threonine kinase Akt and to induce apoptosis in cancer cell lines with high levels of endogenous Akt activity.
T79722 2-Chlorophenoxazine

Akt Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
2-Chlorophenoxazine为Akt抑制剂,体外IC50为2-5 μM,能够诱导细胞凋亡(apoptosis),适用于癌症病理研究。
T35490 2-Amino-5-bromo-6-chloropyrazine

2-Amino-5-bromo-6-chloropyrazine is a heterocyclic building block.1,2It has been used in the synthesis of Akt inhibitors. 1.Kettle, J.G., Brown, S., Crafter, C., et al.Diverse heterocyclic scaffolds as allosteric inhibitors of AKTJ. Med. Chem.55(3)1261-1273(2012) 2.Goel, R., Luxami, V., and Paul, K.Recent advances in development of imidazo[1,2-a]pyrazines: Synthesis, reactivity and their biological applicationsOrg. Biomol. Chem.13(12)3525-3555(2015)
T29543 ACAF4

ACAF-4,ACAF 4

ACAF4 is a neurotrophic agent which significantly increases survival in PC12 neuronal cells and enhances the effect of nerve growth factor (NGF). ACAF4 induces neurite outgrowth, and modulates ERK1/2 and AKT signaling pathways.
T62013 PI3Kδ-IN-10

PI3Kδ-IN-10 是高效的、具有口服活性的PI3Kδ抑制剂(IC50= 2 nM)。在肝细胞癌模型中,PI3Kδ-IN-10 强烈抑制下游AKT 通路,并诱导细胞凋亡(apoptosis)。
T22247 Miransertib (ARQ 092) HCl

Miransertib hydrochloride (ARQ-092 hydrochloride) is a powerful, orally bioavailable, selective, and allosteric inhibitor of Akt. It exhibits an inhibitory concentration (IC50) of 2.7 nM, 14 nM, and 8.1 nM against Akt1, Akt2, and Akt3, respectively. In addition to its Akt inhibitory activity, Miransertib hydrochloride also demonstrates significant potency as an inhibitor of the AKT1-E17K mutant protein. This compound shows promise in research related to PI3K/AKT-driven tumors and Proteus syndrom...
T72886 Akt1&PKA-IN-2

Akt1&PKA-IN-2 ((R)-29) 是一种具有周期蛋白依赖性激酶 2 (CDK2) 选择性的酰胺类 PKB/AKT 抑制剂。Akt1&PKA-IN-2 抑制 AKT1、PKAa 和 CDK2a,IC50值分别为 0.007 µM、0.01 µM 和 0.69 µM。
T70926 BRN-103

BRN-103 was found to suppress the VEGF-induced phosphorylation of VEGF receptor 2 (VEGR2) and the activations of AKT and eNOS. Taken together, these results suggest that BRN-103 inhibits VEGF-mediated angiogenesis signaling in human endothelial cells.
T78149 ZINC00784494

Others Others
ZINC00784494 是一种特异性脂质运载蛋白-2(LCN2)抑制剂,可阻抑细胞增殖和活力,同时减少SUM149细胞的AKT磷酸化水平,对炎症性乳腺癌(IBC)具有研究潜力。
T61522 Nrf2/HO-1 activator 2

Nrf2/HO-1 activator 2 (compound 13m), a difluoro-substituted derivative, is a highly potent activator of Nrf2/HO-1. It exhibits substantial neuroprotective and antioxidant properties by activating the Nrf2/HO-1 pathway through phosphorylation of ERK1/2, JNK, or Akt in PC12 cells. This compound finds utility in the investigation of Parkinson's disease (PD) [1].
T79458 YF704

YF704 (化合物 4w) 作为一种选择性SHP2变构抑制剂,具有0.25 μM的半抑制浓度(IC50)。该化合物在癌细胞中表现出抗增殖效果,并能诱导细胞凋亡。YF704 同时能够降低癌细胞内Erk1/2Akt的磷酸化水平。
T74833 EGFR T790M/L858R-IN-2

EGFRT790M/L858R-IN-2 是一种有效的选择性EGFRT790M/L858R 抑制剂,对 EGFRT790M/L858R 和EGFRWT 的IC50值分别为 3.5, 1290 nM。EGFRT790M/L858R-IN-2 降低 p-EGFR、P-AKT、P-ERK1/2 的表达。EGFRT790M/L858R-IN-2 诱导细胞凋亡 (Apoptosis) 和细胞周期停滞在 G1 期。EGFRT790M/L858R-IN-2 具有抗癌活性。
T63967 Multi-kinase-IN-2

Multi-kinase-IN-2 是口服具有活力的血管激酶 (angiokinase) 抑制剂。Multi-kinase-IN-2 能够显著抑制血管激酶的活性,如 VEGFR-1/2/3、PDGFRα/β、FGFR-1、LYN 和 c-KIT 激酶。Multi-kinase-IN-2 能够明显减弱 AKT 和 ERK 蛋白的磷酸化,并可诱导细胞凋亡 (apoptosis),具有抗癌作用。
T69990 Ruboxistaurin mesylate monohydrate

Ruboxistaurin mesylate monohydrate is a PKC beta inhibitor potentially for the treatment of diabetic nephropathy and diabetic macular edema. Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/Smad and GRAP pathways. Ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Ruboxistaurin inhibits retinal neovascularization via suppression of phosphorylation of ERK1/2 and Akt.
T3689L Ruboxistaurin mesylate

LY-333531,LY333531,LY 333531,LY-333531 Mesylate

Ruboxistaurin is a PKC beta inhibitor. Ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/
T76800 Dalotuzumab

Dalotuzumab (MK-0646) 是一种靶向IGF-1R 的重组人源化单克隆抗体 (IgG1 型)。Dalotuzumab 通过抑制IGF-1和IGF-2介导的肿瘤细胞增殖、IGF-1R 自体磷酸化和Akt 磷酸化而发挥作用。Dalotuzumab 还可诱导细胞凋亡和周期停滞。Dalotuzumab 与其他抗癌活性分子(如他汀类活性分子)共同使用,可增强 Dalotuzumab 的体外和体内抗肿瘤活性。
T61476 Thioridazine

Thioridazine is a chemical compound characterized by its potent anti-psychotic and anti-anxiety activities. As an antagonist of the dopamine receptor D2 family proteins, it exhibits a strong inhibitory effect on the PI3K-Akt-mTOR signaling pathways, resulting in anti-angiogenic effects. It also demonstrates significant antiproliferative and apoptosis induction effects in a diverse range of cancer cells, specifically targeting cancer stem cells (CSCs) [1] [2] [3] [4].
T81784 MK-2206 free base

Akt Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
MK-2206 free base是一种口服活性、高选择性的变构Akt抑制剂,IC50分别针对Akt1、Akt2Akt3为8、12和65 nM 。多种乳腺癌细胞系、PIK3CA突变以及PTEN缺失细胞系对此化合物敏感,显示出抗癌活性。
T78608 Anticancer agent 164

Apoptosis Apoptosis
CML-IN-1(compound 7)是一种高效抗癌药物,针对人类慢性粒细胞白血病(CML)细胞系K562,能有效诱导凋亡(apoptosis)。该化合物主要通过显著抑制PI3K/Akt信号通路的蛋白磷酸化来发挥作用,同时CML-IN-1(compound 4)也能通过抑制结直肠癌的MEK/ERK信号通路来阻止细胞增殖。
T35855 AAA

AAA is an antagonist of G protein-coupled receptor 75 (GPR75).1It increases basal GPR75 protein levels and inhibits 20-HETE-induced reductions in GPR75 protein levels in PC3 cells. AAA (5 and 10 μM) also reduces 20-HETE-induced phosphorylation of EGFR, NF-κB, and Akt in, and cell migration of, PC3 cells.In vivo, AAA (10 mg/kg per day) reduces systolic blood pressure, albuminuria, renal angiotensin II levels, and cardiac hypertrophy in a Cyp1a1-Ren-2 transgenic rat model of malignant hypertension...
T68980 MRK003

MRK003 is a γ-secretase inhibitor exhibits promising in vitro pre-clinical activity in multiple myeloma and non-Hodgkin's lymphoma. MRK003 treatment induced caspase-dependent apoptosis and inhibited proliferation of MM and NHL cell lines and patient cells. Examination of signaling events after treatment showed time-dependent decrease in levels of the notch intracellular domain, Hes1 and c-Myc. MRK003 downregulated cyclin D1, Bcl-Xl and Xiap levels in NHL cells and p21, Bcl-2 and Bcl-Xl in MM cel...
T79487 MAO A/HSP90-IN-2

Monoamine Oxidase Neuroscience
MAO A/HSP90-IN-2(compound 4-C)是一种针对HSP90和MAO A的双重抑制剂,显示出分别对这两种酶有0.016 μM和4.58 μM的IC50值。该化合物能够上调HSP70,降低HER2和磷酸化AKT的表达,同时能减少GL26细胞中由IFN-γ诱导的PD-L1表达增加。此外,MAO A/HSP90-IN-2能够抑制对Temozolomide敏感或耐药的胶质母细胞瘤(GBM)、结肠癌、白血病和非小细胞肺癌细胞的生长,并可能有助于阻止肿瘤逃避免疫监控。
T127402 Coenzyme Q0

CoQ0

Coenzyme Q0 (CoQ0) 是一种口服有效的醌类化合物,可以从Antrodia cinnamomea 中得到。Coenzyme Q0 诱导细胞凋亡 (apoptosis) 和自噬 (autophagy),抑制 HER-2/AKT/mTOR 信号通路来增强细胞凋亡和自噬机制。Coenzyme Q0 调节 NFκB/AP-1 的激活,并增强 Nrf2 的稳定,减轻炎症和氧化还原失衡。Coenzyme Q0 通过下调 MMP-9/NF-κB 和上调 HO-1 信号通路具有抗血管生成活性。
T75238 YS-49 monohydrate

YS-49 (monohydrate) 是PI3K/Akt(RhoA 的下游靶标) 的激活剂,可减少 3-甲基胆碱处理的细胞中 RhoA/PTEN 的激活。YS-49 能通过诱导血红素加氧酶 (HO-1) 来抑制血管紧张素 II (Ang II)刺激 VSMC 细胞的增殖。YS-49 是异喹啉化合物生物碱,因能激活心脏β-adrenoceptors 而具有强烈的正性肌力作用。
T41240 Verrucarin A

Verrucarin A (Muconomycin A) 是一种 D 型大环真菌毒素。Verrucarin A 是一种蛋白质合成 (protein synthesis) 的抑制剂,来源于Myrothecium verrucaria,可抑制白血病细胞系生长,并激活巨噬细胞 caspases、凋亡和炎症信号。Verrucarin A 能有效提高 p38 MAPK 的磷酸化,降低 ERK/Akt 的磷酸化。Verrucarin A 通过 p21 和 p53 的诱导引起细胞周期调控的解除。
T83877 2-(cyclohexylmethyl)-Plumbagin

2-(cyclohexylmethyl)-Plumbagin是naphthoquinone plumbagin的衍生物。在模拟胰腺癌肿瘤微环境的营养匮乏条件下,与营养丰富条件下的PANC-1细胞相比,对PANC-1人类胰腺癌细胞表现出选择性的细胞毒性,50%优选细胞毒性值(PC50s)分别为0.11和47.2 µM。1 µM浓度下,还可诱导PANC-1细胞发生凋亡。此外,2-(cyclohexylmethyl)-Plumbagin在营养匮乏条件下,而非营养丰富条件下,选择性降低PANC-1细胞中Akt和哺乳动物雷帕霉素靶蛋白(mTOR)的磷酸化。在以每周五次、每次50和250 µg/动物剂量给药的MiaPaCa-2胰腺癌小鼠异种移植模型中,能减少肿瘤体积和重量。
T79560 22-(4′-py)-JA

22-(4′-Pyridinecarbonyl) jorunnamycin A

Akt Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
22-(4′-py)-JA是久那霉素A的半合成衍生物,源自泰国蓝海绵(Xestospongia sp.)。该化合物显示出抗转移活性,能抑制AKT/mTOR/p70S6K信号通路,并阻断人脐静脉内皮细胞(HUVEC)中肿瘤细胞侵袭及管形成作用。它通过下调金属蛋白酶(MMP-2和MMP-9)、缺氧诱导因子1α(HIF-1α)和血管内皮生长因子(VEGF)来发挥作用。此外,22-(4′-py)-JA对非小细胞肺癌(NSCLC)显示出显著的抗癌效果。
T35806 N-Stearoylsphingosine

C(18:0)/C(18:1),Cer(d18:1/18:0),C18 Ceramide (d18:1/18:0),C18 Ceramide

Phosphatase Metabolism
N-Stearoylsphingosine (Cer(d18:1/18:0)) 是一种广泛存在真核生物体内的酰胺类化合物,通过干扰PP2A与PP2A抑制剂2的结合来增强蛋白质磷酸酶2A(PP2A)活性,导致Akt去磷酸化。N-Stearoylsphingosine 可用于研究前列腺癌。
T38263 TBK1/IKKε-IN-4

TBK1/IKKε-IN-4

TBK1/IKKε-IN-4 is a 6-aminopyrazolopyrimidine derivative and a potent, selective TBK1 and IKKε inhibitor with IC50 values of 13 nM and 59 nM, respectively. TBK1/IKKε-IN-4 shows 100- to 1000-fold less activity against other protein kinases including PDK1, PI3K family members and mTOR[1]. TBK1/IKKε-IN-4 (Compound II; 96 hours; A549 andHCC44 cells) treatmentdisplays selective toxicity in TBK1-dependent cancer cell lines (IC50 of ~ 4.2 μM for H441 cells and IC50 of ~0.4 μM for A549 cells)[1].TBK1/IK...
T28157 Nephrin

Nephrin is a cell surface signaling receptor protein that regulates podocyte function and plays a role in β-cell survival signaling; it is a protein necessary for the proper functioning of the renal filtration barrier. Nephrin belongs to a family of highl
T79311 CNBCA

CNBCA是一种有效的SHP2酶抑制剂,具有选择性和竞争性,IC50值为0.87 μM。该化合物可结合SHP2全长蛋白并抑制其酶活性,进而阻止Akt和ERK1/2的磷酸化,以及抑制BT474和MDA-MB468乳腺癌细胞的生长。CNBCA主要用于乳腺癌的研究。
T36991 Monascuspiloin

Monascuspiloin is a fungal metabolite that has been found inM. pilosusM93-fermented rice.1It induces endoplasmic reticulum stress and autophagy in PC3 prostate cancer cells. Monascuspiloin (15-45 μM) decreases viability of PC3 cells and has an additive effect on the reduction in viability of PC3 cells induced by irradiation when used at a concentration of 25 μM. It induces intratumor apoptosis and autophagy and reduces tumor growth in a PC3 mouse xenograft model when administered at doses of 40 ...
T35897 ASK120067

ASK120067 is a potent and orally active inhibitor of EGFRT790M (IC50:0.3 nM) with selectivity over EGFRWT (IC50:6.0 nM). ASK120067 is a third-generation EGFR-TKI for the research of non-small cell lung cancer (NSCLC)[1]. In the in vitro kinase assay ASK120067 potently inhibits the EGFR L858R/T790M and EGFR T790M resistant mutants with IC50 values of 0.3 nM and 0.5 nM, respectively, as well as the EGFRexon19del sensitizing mutant (IC50= 0.5 nM). The 50 of ASK120067 against wild-type EGFR (EGFRWT...
T35527 PI3Kα-IN-4

PI3Kα-IN-4

PI3Kα-IN-4 is a potent, selective and orally active inhibitor of PI3Kα, with an IC50 of 1.8 nM. PI3Kα-IN-4 has antitumor activity[1]. PI3Kα-IN-4 (compound 10) inhibits PI3Kα, β, δ, and γ, with IC50s of 1.8, 271.0, 13.9, and 13.8 nM, respectively in kinase assays[1].PI3Kα-IN-4 inhibits PI3Kα, β, δ, and γ, with IC50s of 12.1,1393, 183, and >10000 nM, respectively in cell based assays[1]. PI3Kα-IN-4 (compound 10) (30 mg/kg; p.o. once daily for 21 d) achieves the best efficacy, which could inhibit t...
T36648 Tucatinib hemiethanolate

Tucatinib (Irbinitinib) hemiethanolate is a potent, orally active and selective HER2 inhibitor with an IC50 of 8 nM. Tucatinib hemiethanolate has nanomolar activity against purified HER2 enzyme and is approximately 500-fold selective for HER2 versus EGFR in cell-based assays. Tucatinib selectively inhibits the receptor tyrosine kinase HER2 relative to EGFR[1].Tucatinib blocks proliferation and the phosphorylation of HER2 and its downstream effector, Akt in HER2 overexpressing cell lines. In the ...
T35519 Aflatoxin B2-13C17

Aflatoxin B2-13C17

Aflatoxin B2-13C17(AFB2-13C17) is intended for use as an internal standard for the quantification of AFB2by GC- or LC-MS. AFB2is a mycotoxin that has been found inA. terricola.1It induces hepatic autophagy and apoptosis in broiler chickens when administered at doses of 0.2, 0.4, and 0.8 mg/kg.2AFB2(0.5 and 1 mg/animal) also induces parenchymal cell hyperplasia in rats.3 1.Moubasher, A.H., el-Kady, I.A., and Shoriet, A.Toxigenic Aspergilli isolated from different sources in EgyptAnn. Nutr. Alimen...

化合物

AKT-IN-2
Cat.No: T10274
Synonym:
Target: Akt
PI3K/Akt/mTOR-IN-2
Cat.No: T60564
Synonym:
Target: Apoptosis, Akt, PI3K, mTOR
PI3K/AKT-IN-2
Cat.No: T72880
Synonym:
Target:
AKT-IN-6
Cat.No: T36310
Synonym: INCB-047775
Target: Akt
6'-GNTI dihydrochloride
Cat.No: T39988
Synonym:
Target: Opioid Receptor, Akt
ZINC00640089
Cat.No: T72968
Synonym:
Target: Akt
CAY10404
Cat.No: T8656
Synonym: 3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T
Target: Apoptosis, Akt, COX
ethyl 2-[3,5-bis(trifluoromethyl)phenyl]-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate
Cat.No: T50107
Synonym:
Target: Others
AMG 511
Cat.No: T14214
Synonym:
Target: PI3K
A-674563 HCl (552325-73-2(free base))
Cat.No: T4444
Synonym:
Target: ERK, Akt, PKA, CDK, PKC
Midostaurin
Cat.No: T3211
Synonym: 米哚妥林,N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251,苯甲酰基十字孢碱
Target: Others, PKC
Akt1&PKA-IN-1
Cat.No: T72885
Synonym:
Target:
1-O-Octadecyl-2-O-methyl-sn-glycerol
Cat.No: T35489
Synonym:
Target:
2-Chlorophenoxazine
Cat.No: T79722
Synonym:
Target: Akt
2-Amino-5-bromo-6-chloropyrazine
Cat.No: T35490
Synonym:
Target:
ACAF4
Cat.No: T29543
Synonym: ACAF-4,ACAF 4
Target:
PI3Kδ-IN-10
Cat.No: T62013
Synonym:
Target:
Miransertib (ARQ 092) HCl
Cat.No: T22247
Synonym:
Target:
Akt1&PKA-IN-2
Cat.No: T72886
Synonym:
Target:
BRN-103
Cat.No: T70926
Synonym:
Target:
ZINC00784494
Cat.No: T78149
Synonym:
Target: Others
Nrf2/HO-1 activator 2
Cat.No: T61522
Synonym:
Target:
YF704
Cat.No: T79458
Synonym:
Target:
EGFR T790M/L858R-IN-2
Cat.No: T74833
Synonym:
Target:
Multi-kinase-IN-2
Cat.No: T63967
Synonym:
Target:
Ruboxistaurin mesylate monohydrate
Cat.No: T69990
Synonym:
Target:
Ruboxistaurin mesylate
Cat.No: T3689L
Synonym: LY-333531,LY333531,LY 333531,LY-333531 Mesylate
Target:
Dalotuzumab
Cat.No: T76800
Synonym:
Target:
Thioridazine
Cat.No: T61476
Synonym:
Target:
MK-2206 free base
Cat.No: T81784
Synonym:
Target: Akt
Anticancer agent 164
Cat.No: T78608
Synonym:
Target: Apoptosis
AAA
Cat.No: T35855
Synonym:
Target:
MRK003
Cat.No: T68980
Synonym:
Target:
MAO A/HSP90-IN-2
Cat.No: T79487
Synonym:
Target: Monoamine Oxidase
Coenzyme Q0
Cat.No: T127402
Synonym: CoQ0
Target:
YS-49 monohydrate
Cat.No: T75238
Synonym:
Target:
Verrucarin A
Cat.No: T41240
Synonym:
Target:
2-(cyclohexylmethyl)-Plumbagin
Cat.No: T83877
Synonym:
Target:
22-(4′-py)-JA
Cat.No: T79560
Synonym: 22-(4′-Pyridinecarbonyl) jorunnamycin A
Target: Akt
N-Stearoylsphingosine
Cat.No: T35806
Synonym: C(18:0)/C(18:1),Cer(d18:1/18:0),C18 Ceramide (d18:1/18:0),C18 Ceramide
Target: Phosphatase
TBK1/IKKε-IN-4
Cat.No: T38263
Synonym: TBK1/IKKε-IN-4
Target:
Nephrin
Cat.No: T28157
Synonym:
Target:
CNBCA
Cat.No: T79311
Synonym:
Target:
Monascuspiloin
Cat.No: T36991
Synonym:
Target:
ASK120067
Cat.No: T35897
Synonym:
Target:
PI3Kα-IN-4
Cat.No: T35527
Synonym: PI3Kα-IN-4
Target:
Tucatinib hemiethanolate
Cat.No: T36648
Synonym:
Target:
Aflatoxin B2-13C17
Cat.No: T35519
Synonym: Aflatoxin B2-13C17
Target:
Cat. No. Product Name Target Signaling Pathways
T5S1331 Herbacetin

c-Met/HGFR; Akt Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
Herbacetin 是一种亚麻籽中的天然类黄酮,具有多种药理活性,如抗氧化、抗炎、抗癌作用。 它是鸟氨酸脱羧酶Ornithine decarboxylase (ODC)变构抑制剂,能够直接与 ODC 上的 Asp44,Asp243 和 Glu384 结合。其中鸟氨酸脱羧酶是多胺生物合成中的限速酶。
T5S2178 Fargesin

辛夷脂素,(+/-)-Fargesin

Adrenergic Receptor GPCR/G Protein; Neuroscience
Fargesin ((+/-)-Fargesin) 是一种活性新木脂素,从木兰植物中分离得到,具有抗高血压和抗炎活性。
T3729 Ethyl gallate

Nipagallin A,Phyllemblin,gallic acid ethyl ester,没食子酸乙酯

MMP; NF-κB; Akt; Antibacterial Cytoskeletal Signaling; Microbiology/Virology; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome
Ethyl gallate (gallic acid ethyl ester) 是一种非类黄酮酚过氧化氢清除剂。
T5S0055 Chelidonine

Helidonine,Khelidonin,白屈菜碱,Stylophorin

Apoptosis; Others; Influenza Virus Apoptosis; Microbiology/Virology; Others
Chelidonine (Stylophorin) 是白屈菜中的一种异喹啉生物碱,有抗肿瘤和抗病毒作用。它可导致细胞周期 G2/M 停滞,诱导 caspase 依赖和非依赖性的细胞凋亡。
T4S1419 (±)-Praeruptorin A

Praeruptorin A,(±)-白花前胡甲素,白花前胡甲素,(-)-Praeruptorin A

p38 MAPK; Calcium Channel; Akt Cytoskeletal Signaling; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling
(±)-Praeruptorin A 是来自白花前胡的干燥根中的一种主要成分,用于研究伴有厚痰和呼吸困难的咳嗽,非天生性咳嗽和上呼吸道感染。它是顺式-内酯 (CKL) 的二酯化产物,可作为 Ca2+-反流阻滞剂,用于高血压的研究。
T4S0498 Glaucocalyxin A

蓝萼甲素,Wangzaozin B,Leukamenin F

Apoptosis; Akt; Caspase; PI3K Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome
Glaucocalyxin A (Leukamenin F) 是来自日本黑纹病菌的一种对映型月桂基二萜,具有抗肿瘤作用。它通过调节PI3K/Akt 信号通路抑制 GLI1 的核易位,诱导骨肉瘤凋亡。
T6S0653 Linarin

Buddleoflavonoloside,Buddleoside,Acacetin-7-O-rutinoside,Acaciin,Linarine,蒙花苷

TNF; AChE Apoptosis; Neuroscience
Linarin (Acacetin-7-O-rutinoside) 是一种选择性的乙酰胆碱酯酶 (AChE) 抑制剂,从薄荷花提取物中分离得到。
T6S0659 Rhynchophylline

钩藤碱,Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin

Calcium Channel; NF-κB Membrane transporter/Ion channel; Metabolism; NF-κB
Rhynchophylline (Mitrinermine) 是一种生物碱类化合物,从钩藤中分离得到,具有很高的生物活性,被广泛用于抗炎、神经保护等方面的研究。
T3923 Calycosin

Cyclosin,3'-Hydroxyformononetin,异黄酮,毛异黄酮

Apoptosis; Tyrosinase Apoptosis; Proteases/Proteasome
Calycosin (Cyclosin) 是一抗氧化和抗炎症活性天然产物。
T6S2099 Geraniin

Antioxidant; TNF Apoptosis; oxidation-reduction
Geraniin 是一种肿瘤坏死因子α释放抑制剂,其IC50值为 43 μM,具有抗肿瘤、抗炎和抗高血糖活性。
T6S1699 Shogaol

[6]-Shogaol,姜烯酚,6-姜烯酚,6-Shogaol

Lipoxygenase; Autophagy Autophagy; Metabolism
6-Shogaol (6-Shogaol) 是从生姜中分离的一种天然产物,具有抗癌、抗炎和抗氧化的多种生物活性。
T6S1315 Oroxylin A

千层纸素A,6-Methoxybaicalein,Baicalein 6-methyl ether

Virus Protease; HIF/HIF Prolyl-Hydroxylase; Autophagy Autophagy; Chromatin/Epigenetic; Metabolism; Microbiology/Virology
Oroxylin A (Baicalein 6-methyl ether) 是一种有活性的黄酮,具有较强的抗癌作用。
T4S21320 ISOGINKGETIN

异银杏素,4',4'''-Dimethylamentoflavone,异银杏双黄酮

MMP; Others Others; Proteases/Proteasome
ISOGINKGETIN (4',4'''-Dimethylamentoflavone) 是一种MMP9抑制剂,也是一种Pre-mRNA Splicing 抑制剂。
T2966 Beta-Sitosterol

Cupreol,谷甾醇,Beta-Sitosterol,β-Sitosterol,Azuprostat,SKF 14463,beta-谷甾醇,22,23-Dihydrostigmasterol,Betaprost

Apoptosis; Lipase; Endogenous Metabolite Apoptosis; Metabolism
Beta-Sitosterol (SKF 14463) 是一种植物甾醇,干扰细胞周期、细胞凋亡、增殖、存活、侵袭、血管生成和炎症等多种细胞信号通路。
T6S0525 Farrerol

ERK; p38 MAPK; Akt Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
Farrerol 是一种杜鹃花的生物活性成分,具有抗氧化、抗肿瘤、抗炎、神经保护和肝保护等多种功能。
T5S1097 Neferine

(R)-1,2-Dimethoxyaporphine,(-)-Neferine,甲基莲心碱

Apoptosis; NF-κB; Autophagy Apoptosis; Autophagy; NF-κB
Neferine ((-)-Neferine) 是一种双苄基异喹啉类生物碱,可强效抑制NF-κB 激活,具有抗肿瘤活性。
T2S0410 Euphorbia factor L1

Euphorbiasteroid,大戟因子L1,大戟因子 L1

Apoptosis; P-gp Apoptosis; Membrane transporter/Ion channel; Neuroscience
Euphorbia factor L1 (Euphorbiasteroid) 是续随子中的二萜类化合物,可降低 Bcl-2,PI3K,AKT 和 mTOR 蛋白和 mRNA 水平,上调 caspase-9 and caspase-3 蛋白水平。它可诱导自噬,具有抗癌、抗脂肪生成、抗破骨细胞生成和多重耐药调节作用。
T6S1740 Nardosinone

苷松新酮,甘松新酮

Others Others
Nardosinone 是一个 dbcAMP 和 staurosporine 的神经生成作用增强剂,分离自Nardostachys chinensis 中。Nardosinone 可能成为一种有用的药理学工具,不仅可用于研究神经生长因子 (NGF) 的作用机理,而且可用于研究神经毒性物质的作用机理。
T5S1982 Periplocin

Periplocoside,杠柳毒苷

Apoptosis; Others Apoptosis; Others
Periplocin (Periplocoside) 是从黑龙骨中分离出的一种强心类固醇。它可促进肿瘤细胞凋亡并抑制肿瘤生长。它通过激活 Na/K-ATPase 介导的 Src/ERK 和 PI3K/Akt 途径,具有促进伤口愈合的潜力。
T3S0209 Vincristine

ERK; p38 MAPK; NF-κB; Akt; JNK; mTOR Cytoskeletal Signaling; MAPK; NF-κB; PI3K/Akt/mTOR signaling
Vincristine 与微管蛋白结合并抑制微管的形成,从而抑制癌细胞的有丝分裂。 Vincristine 可用作微管去稳定剂,用于研究治疗血液系统癌症,如白血病和淋巴瘤以及儿童肉瘤的相关研究。
T3826 Polygalasaponin F

异牡荆苷,瓜子金皂苷己

NF-κB; TLR; Akt; PI3K Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR signaling
Polygalasaponin F 是从瓜子金中提取的齐墩果烷型三萜皂苷,可通过调节TLR4-PI3K/AKT-NF-kB 信号通路减少神经炎症细胞因子的分泌,能降低炎性细胞因子肿瘤坏死因子 α 的释放。
T3895 Polyphyllin I

重楼皂苷I,重楼皂甙

Apoptosis; Akt; JNK; PDK; mTOR; Autophagy Apoptosis; Autophagy; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
Polyphyllin I 是从七叶一枝花中提取的生物活性成分,具有很强的抗肿瘤活性。它是 JNK 信号通路的激活剂,也是 PDK1/Akt/mTOR 信号传导的抑制剂。它诱导自噬,G2/M 期阻滞和细胞凋亡。
T6S1559 Aurantio-obtusin

Others Others
Aurantio-obtusin 是从决明子中分离出的蒽醌类化合物,具有抗炎、抗凝血、抗氧化、抗高血压的活性。它能抑制 IgE 介导的肥大细胞和过敏模型中的过敏反应,具有研究过敏相关疾病的潜力。在大鼠中,它通过内皮细胞 PI3K/AKT/ eNOS 依赖信号通路放松全身动脉,是潜在的新型血管扩张剂。
T2940 6-Hydroxyflavone

6-羟基黄酮,6-HF

GABA Receptor Membrane transporter/Ion channel; Neuroscience
6-Hydroxyflavone (6-HF) 是天然存在的黄酮化合物,具有抗炎作用。它对牛血红蛋白糖基化具有抑制作用。它能激活 AKT、ERK 1/2、JNK 信号通路,有效促进成骨细胞分化。它能抑制 LPS 诱导的 NO 的产生。
T2S2215 Crebanine

Apoptosis; Others; Akt Apoptosis; Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling
Crebanine 是来自于韦诺萨千金藤的一种生物碱,通过抑制 MAPKs 和 Akt 信号通路表现出抗炎活性,还具有抗心律失常的作用。它可诱导人类癌细胞的 G1阻滞和凋亡。
TN6419 Chamaejasmine

Chamaejasmine could be a candidate drug for osteosarcoma and breast cancer chemoprevention, induces apoptosis in MG63 and HEp-2 cells by Akt inactivation and dephosphorylation of BAD. It inhibits Bcl-2 expression and induces Bax expression to desintegrate
TN5100 Taspine

ERK; EGFR; BCL; VEGFR; MAPK; Akt Angiogenesis; Apoptosis; Cytoskeletal Signaling; JAK/STAT signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo, it can inhibit growth and induce apoptosis of HUVEC in a dose-dependent manner, it has shown meaningful angiogenesis activity. Taspine exhibi
T4S0083 Protostemonine

Others Others
Protostemonine 是一种主要从 Stemona sesslifolia 根中分离得到的生物碱,对哮喘及革兰氏阴性菌所致急性肺损伤有抗炎作用。
TN4168 Grifolin

Others Others
Grifolin has anti-cancer effects, it induces apoptosis and promotes cell cycle arrest in the A2780 human ovarian cancer cell line via inactivation of the ERK1/2 and Akt pathways; it enhances the differentiation and proliferation of oligodendrocyte precurs
TN4046 Excisanin A

MMP; FAK; PARP; GSK-3; NF-κB; Wnt/beta-catenin; Akt; Caspase; PI3K; Prostaglandin Receptor; JNK Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; MAPK; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatment of breast cancer. Excisanin A shows comparable inhibitory effects on the LPS-induced production of NO and PGE2, and activation of NF-kappaB without affecting cell viability.Excisanin A induces apoptosis in colon cancer cell line SW620 as determined by Annexin V staining, the ...
TN5050 Sprengerinin C

NADPH-oxidase; VEGFR; p38 MAPK; ROS; Akt; PI3K; mTOR; p53 Angiogenesis; Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can strongly suppress tumor angiogenesis in human umbilical vein endothelial cells, it blocks vascul
TN3806 Dehydroglyasperin C

ERK; IκB/IKK; p38 MAPK; TNF; NF-κB; Akt; COX; PI3K; NADPH; DNA/RNA Synthesis; Nrf2; JNK; Autophagy Apoptosis; Autophagy; Cell Cycle/Checkpoint; Cytoskeletal Signaling; DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; Metabolism; Neuroscience; NF-κB; PI3K/Akt/mTOR signaling
Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemopreventive, and neuroprotective activities, it has protective effects against chronic diseases

天然产物

Herbacetin
Cat.No: T5S1331
Synonym:
Target: c-Met/HGFR, Akt
Fargesin
Cat.No: T5S2178
Synonym: 辛夷脂素,(+/-)-Fargesin
Target: Adrenergic Receptor
Ethyl gallate
Cat.No: T3729
Synonym: Nipagallin A,Phyllemblin,gallic acid ethyl ester,没食子酸乙酯
Target: MMP, NF-κB, Akt, Antibacterial
Chelidonine
Cat.No: T5S0055
Synonym: Helidonine,Khelidonin,白屈菜碱,Stylophorin
Target: Apoptosis, Others, Influenza Virus
(±)-Praeruptorin A
Cat.No: T4S1419
Synonym: Praeruptorin A,(±)-白花前胡甲素,白花前胡甲素,(-)-Praeruptorin A
Target: p38 MAPK, Calcium Channel, Akt
Glaucocalyxin A
Cat.No: T4S0498
Synonym: 蓝萼甲素,Wangzaozin B,Leukamenin F
Target: Apoptosis, Akt, Caspase, PI3K
Linarin
Cat.No: T6S0653
Synonym: Buddleoflavonoloside,Buddleoside,Acacetin-7-O-rutinoside,Acaciin,Linarine,蒙花苷
Target: TNF, AChE
Rhynchophylline
Cat.No: T6S0659
Synonym: 钩藤碱,Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin
Target: Calcium Channel, NF-κB
Calycosin
Cat.No: T3923
Synonym: Cyclosin,3'-Hydroxyformononetin,异黄酮,毛异黄酮
Target: Apoptosis, Tyrosinase
Geraniin
Cat.No: T6S2099
Synonym:
Target: Antioxidant, TNF
Shogaol
Cat.No: T6S1699
Synonym: [6]-Shogaol,姜烯酚,6-姜烯酚,6-Shogaol
Target: Lipoxygenase, Autophagy
Oroxylin A
Cat.No: T6S1315
Synonym: 千层纸素A,6-Methoxybaicalein,Baicalein 6-methyl ether
Target: Virus Protease, HIF/HIF Prolyl-Hydroxylase, Autophagy
ISOGINKGETIN
Cat.No: T4S21320
Synonym: 异银杏素,4',4'''-Dimethylamentoflavone,异银杏双黄酮
Target: MMP, Others
Beta-Sitosterol
Cat.No: T2966
Synonym: Cupreol,谷甾醇,Beta-Sitosterol,β-Sitosterol,Azuprostat,SKF 14463,beta-谷甾醇,22,23-Dihydrostigmasterol,Betaprost
Target: Apoptosis, Lipase, Endogenous Metabolite
Farrerol
Cat.No: T6S0525
Synonym:
Target: ERK, p38 MAPK, Akt
Neferine
Cat.No: T5S1097
Synonym: (R)-1,2-Dimethoxyaporphine,(-)-Neferine,甲基莲心碱
Target: Apoptosis, NF-κB, Autophagy
Euphorbia factor L1
Cat.No: T2S0410
Synonym: Euphorbiasteroid,大戟因子L1,大戟因子 L1
Target: Apoptosis, P-gp
Nardosinone
Cat.No: T6S1740
Synonym: 苷松新酮,甘松新酮
Target: Others
Periplocin
Cat.No: T5S1982
Synonym: Periplocoside,杠柳毒苷
Target: Apoptosis, Others
Vincristine
Cat.No: T3S0209
Synonym:
Target: ERK, p38 MAPK, NF-κB, Akt, JNK, mTOR
Polygalasaponin F
Cat.No: T3826
Synonym: 异牡荆苷,瓜子金皂苷己
Target: NF-κB, TLR, Akt, PI3K
Polyphyllin I
Cat.No: T3895
Synonym: 重楼皂苷I,重楼皂甙
Target: Apoptosis, Akt, JNK, PDK, mTOR, Autophagy
Aurantio-obtusin
Cat.No: T6S1559
Synonym:
Target: Others
6-Hydroxyflavone
Cat.No: T2940
Synonym: 6-羟基黄酮,6-HF
Target: GABA Receptor
Crebanine
Cat.No: T2S2215
Synonym:
Target: Apoptosis, Others, Akt
Chamaejasmine
Cat.No: TN6419
Synonym:
Target:
Taspine
Cat.No: TN5100
Synonym:
Target: ERK, EGFR, BCL, VEGFR, MAPK, Akt
Protostemonine
Cat.No: T4S0083
Synonym:
Target: Others
Grifolin
Cat.No: TN4168
Synonym:
Target: Others
Excisanin A
Cat.No: TN4046
Synonym:
Target: MMP, FAK, PARP, GSK-3, NF-κB, Wnt/beta-catenin, Akt, Caspase, PI3K, Prostaglandin Receptor, JNK
Sprengerinin C
Cat.No: TN5050
Synonym:
Target: NADPH-oxidase, VEGFR, p38 MAPK, ROS, Akt, PI3K, mTOR, p53
Dehydroglyasperin C
Cat.No: TN3806
Synonym:
Target: ERK, IκB/IKK, p38 MAPK, TNF, NF-κB, Akt, COX, PI3K, NADPH, DNA/RNA Synthesis, Nrf2, JNK, Autophagy
Cat. No. Product Name Species Expression System
TMPY-02333 ULBP-2 Protein, Human, Recombinant (His)

ALCAN-α,UNQ463 / PRO791,NKG2DL2,ALCAN-alph...

Human HEK293
NKG2D ligand 2, also known as N2DL-2, NKG2DL2, ALCAN-alpha, Retinoic acid early transcript 1H, UL16-binding protein 2, ULBP2 and N2DL2, is cell membrane protein that belongs to the MHC class I family. ULBP2 / N2DL-2 is expressed in various types of cancer cell lines and in the fetus, but not in normal tissues. ULBP2 / N2DL-2 is a ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cy...
TMPY-05592 ULBP-2 Protein, Human, Recombinant(aa 1-217, His&AVI),Biotinylated

ALCAN-α,NKG2DL2,RAET1H,UL16 bind<...

Human HEK293
NKG2D ligand 2, also known as N2DL-2, NKG2DL2, ALCAN-alpha, Retinoic acid early transcript 1H, UL16-binding protein 2, ULBP2 and N2DL2, is cell membrane protein that belongs to the MHC class I family. ULBP2 / N2DL-2 is expressed in various types of cancer cell lines and in the fetus, but not in normal tissues. ULBP2 / N2DL-2 is a ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cy...
TMPY-04829 G-CSF Protein, Human, Recombinant

G-CSF,colony stimulating factor 3 (granulocyte),集落刺...

Human HEK293
Granulocyte-colony stimulating factor (G-CSF) is a growth factor and an essential cytokine belonging to the CSF family of hormone-like glycoproteins. It is produced by numerous cell types including immune and endothelial cells. G-CSF binding to its receptor G-CSF-R which belongs to the cytokine receptor type I family depends on the interaction of alpha-helical motifs of the former and two fibronectin type III as well as an immunoglobulin-like domain of the latter. Recent animal studies have also...
TMPY-01413 Cripto Protein, Human, Recombinant (His)

CR,CRIPTO,teratocarcinoma-derived growth factor 1,C...

Human HEK293
Cripto/TDGF1 is a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family. EGF-CFC family member proteins share a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hydrophobic region. Before gastrulation, Cripto is asymmetrically expressed in a proximal–distal gradient in the epiblast, and subsequently is expressed in the primitive streak and newly formed embryonic mesoderm. These proteins play key roles in intercellular signaling pathways du...
TMPY-05260 PD-1 Protein, Cynomolgus, Recombinant (His)

programmed cell death 1

Cynomolgus HEK293
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPY-00996 PD-1 Protein, Mouse, Recombinant (His)

programmed cell death 1,Pdc1,Ly101,PD-1

Mouse HEK293
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPY-04342 PD-1 Protein, Canine, Recombinant (His)

programmed cell death 1

Canine HEK293
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPY-05079 PD-1 Protein, Human, Recombinant (mFc)

PD-1,SLEB2,hSLE1,CD279,programmed cell dea...

Human HEK293
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPY-00897 PD-1 Protein, Human, Recombinant (His)

PD1,hPD-l,hPD-1,CD279,programmed cell death 1,hSLE1...

Human HEK293
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPY-05395 PD-1 Protein, Mouse, Recombinant (hFc)

Ly101,PD-1,programmed cell death 1,Pdc1

Mouse HEK293
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPY-05815 PD-1 Protein, Canine, Recombinant (His & Avi), Biotinylated

programmed cell death 1

Canine HEK293
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPY-04898 PD-1 Protein, Human, Recombinant (hFc)

PD1,programmed cell death 1,PD-1,hPD-l,hSLE1,CD279,...

Human HEK293
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPY-05636 G-CSF Protein, Mouse, Recombinant

G-CSF,MGI-IG,Csfg,集落刺激因子,colony stimulating factor ...

Mouse HEK293
Granulocyte-colony stimulating factor (G-CSF) is a growth factor and an essential cytokine belonging to the CSF family of hormone-like glycoproteins. It is produced by numerous cell types including immune and endothelial cells. G-CSF binding to its receptor G-CSF-R which belongs to the cytokine receptor type I family depends on the interaction of alpha-helical motifs of the former and two fibronectin type III as well as an immunoglobulin-like domain of the latter. Recent animal studies have also...
TMPK-01263 B7-H7 Protein, Cynomolgus, Recombinant (His)

B7H7,B7-H7,HHLA2,B7 Homolog 7

Cynomolgus HEK293
B7-H7, also known as HHLA2 (HERV-H LTR-associating 2), is a member of the B7 family of immune regulatory proteins.Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.
TMPY-02334 ULBP-2 Protein, Human, Recombinant (hFc)

N2DL2,ALCAN-alpha,ALCAN-α,UNQ463 / PRO791,...

Human HEK293
NKG2D ligand 2, also known as N2DL-2, NKG2DL2, ALCAN-alpha, Retinoic acid early transcript 1H, UL16-binding protein 2, ULBP2 and N2DL2, is cell membrane protein that belongs to the MHC class I family. ULBP2 / N2DL-2 is expressed in various types of cancer cell lines and in the fetus, but not in normal tissues. ULBP2 / N2DL-2 is a ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cy...
TMPY-00813 G-CSF Protein, Human, Recombinant (hFc)

CSF3OS,C17orf33,colony stimulating factor 3 (granul...

Human HEK293
Granulocyte-colony stimulating factor (G-CSF) is a growth factor and an essential cytokine belonging to the CSF family of hormone-like glycoproteins. It is produced by numerous cell types including immune and endothelial cells. G-CSF binding to its receptor G-CSF-R which belongs to the cytokine receptor type I family depends on the interaction of alpha-helical motifs of the former and two fibronectin type III as well as an immunoglobulin-like domain of the latter. Recent animal studies have also...
TMPJ-00978 PIP4K2A Protein, Human, Recombinant (His)

Diphosphoinositide kinase 2-α,Ptd...

Human Human Cells
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP4K2A) is a member of the phosphatidylinositol-4-phosphate 5-kinase family. It contains 1 PIPK domain and is expressed ubiquitously, with high levels in the brain. It catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). It may exert its function by regulating the levels of PtdIns5P, which functions in the...
TMPY-04286 IL-22RA1 Protein, Rat, Recombinant (hFc)

interleukin 22 receptor,...

Rat HEK293
IL-22R belongs to the type II cytokine receptor family. It contains 2 fibronectin type-III domains and is expressed in the colon, liver, lung, pancreas, and kidney. IL-22R also can be expressed in keratinocytes of normal skin as well as in psoriatic skin lesions. Overexpression of IL-22R can be detected in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients. IL-22R is a component of the receptor for IL20, IL22, and IL24. The component of IL-22R formed by IL22RA1 and I...
TMPY-04087 IL-22RA1 Protein, Canine, Recombinant (His)

interleukin 22 receptor,...

Canine HEK293
IL-22R belongs to the type II cytokine receptor family. It contains 2 fibronectin type-III domains and is expressed in the colon, liver, lung, pancreas, and kidney. IL-22R also can be expressed in keratinocytes of normal skin as well as in psoriatic skin lesions. Overexpression of IL-22R can be detected in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients. IL-22R is a component of the receptor for IL20, IL22, and IL24. The component of IL-22R formed by IL22RA1 and I...
TMPY-04287 IL-22RA1 Protein, Rat, Recombinant (His)

interleukin 22 receptor,...

Rat HEK293
IL-22R belongs to the type II cytokine receptor family. It contains 2 fibronectin type-III domains and is expressed in the colon, liver, lung, pancreas, and kidney. IL-22R also can be expressed in keratinocytes of normal skin as well as in psoriatic skin lesions. Overexpression of IL-22R can be detected in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients. IL-22R is a component of the receptor for IL20, IL22, and IL24. The component of IL-22R formed by IL22RA1 and I...
TMPY-04002 IL-22RA1 Protein, Canine, Recombinant (hFc)

interleukin 22 receptor,...

Canine HEK293
IL-22R belongs to the type II cytokine receptor family. It contains 2 fibronectin type-III domains and is expressed in the colon, liver, lung, pancreas, and kidney. IL-22R also can be expressed in keratinocytes of normal skin as well as in psoriatic skin lesions. Overexpression of IL-22R can be detected in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients. IL-22R is a component of the receptor for IL20, IL22, and IL24. The component of IL-22R formed by IL22RA1 and I...
TMPY-03908 Cripto Protein, Rat, Recombinant (His)

teratocarcinoma-derived growth factor 1

Rat HEK293
Cripto/TDGF1 is a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family. EGF-CFC family member proteins share a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hydrophobic region. Before gastrulation, Cripto is asymmetrically expressed in a proximal–distal gradient in the epiblast, and subsequently is expressed in the primitive streak and newly formed embryonic mesoderm. These proteins play key roles in intercellular signaling pathways du...
TMPY-05503 Cripto Protein, Human, Recombinant (hFc)

teratocarcinoma-derived growth factor 1,CR,CRIPTO,C...

Human HEK293
Cripto/TDGF1 is a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family. EGF-CFC family member proteins share a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hydrophobic region. Before gastrulation, Cripto is asymmetrically expressed in a proximal–distal gradient in the epiblast, and subsequently is expressed in the primitive streak and newly formed embryonic mesoderm. These proteins play key roles in intercellular signaling pathways du...
TMPY-02679 Cripto Protein, Rat, Recombinant (hFc)

teratocarcinoma-derived growth factor 1

Rat HEK293
Cripto/TDGF1 is a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family. EGF-CFC family member proteins share a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hydrophobic region. Before gastrulation, Cripto is asymmetrically expressed in a proximal–distal gradient in the epiblast, and subsequently is expressed in the primitive streak and newly formed embryonic mesoderm. These proteins play key roles in intercellular signaling pathways du...
TMPY-03795 EIF5A2 Protein, Human, Recombinant (His)

eIF5AII,eukaryotic translation initiation factor 5A...

Human E. coli
Eukaryotic translation initiation factor 5A2 (EIF5A2) has been demonstrated to be upregulated in numerous types of human cancer and is associated with cancer progression. Silencing of EIF5A2 in the NSCLC cells resulted in the downregulation of the tumorigenic proteins, apoptosis regulator Bcl-2 and myc proto-oncogene protein, and upregulation of E-cadherin, suggesting that EIF5A2 promotes proliferation and metastasis through these proteins. EIF5A2 may therefore serve as a novel therapeutic targe...
TMPY-04562 GRK2 Protein, Human, Recombinant (His & GST)

β,adrenergic, beta, receptor kinase 1

Human Baculovirus-Insect Cells
G-protein coupled receptor kinase 2 (GRK2), also referred as Adrenergic, beta, receptor kinase 1 (ADRBK1), is a ubiquitous member of the G protein-coupled receptor kinase (GRK) family that appears to play a central, integrative role in signal transduction cascades. GRK2 can phosphorylate a growing number of non-GPCR substrates and associate with a variety of proteins related to signal transduction, thus suggesting that this kinase could also have diverse 'effector' functions. GRK2 has been repor...
TMPY-04084 ANGPTL1 Protein, Canine, Recombinant (hFc)

angiopoietin-like 1

Canine HEK293
Angiopoietin-like protein 1 (ANGPTL1) has been reported to suppress migration and invasion in lung and breast cancer, acting as a novel tumor suppressor candidate. Downregulation of tumor suppressor signaling plays an important role in the pathogenesis of hepatocellular carcinoma (HCC).The downregulation of the angiopoietin-like protein ANGPTL1 is associated with vascular invasion, tumor thrombus, metastasis, and poor prognosis in HCC. Ectopic expression of ANGPTL1 in HCC cells effectively decre...
TMPY-06336 PD-1 Protein, Human, Recombinant (hFc & Avi), Biotinylated

SLEB2,hPD-1,programmed cell death 1,PD1,hPD-l,PD-1,...

Human HEK293
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPY-00896 PD-1 Protein, Human, Recombinant (His & hFc)

PD1,hPD-l,SLEB2,programmed cell death 1,hSLE1,PD-1,...

Human HEK293
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPY-04341 PD-1 Protein, Rat, Recombinant (His)

programmed cell death 1

Rat HEK293
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPY-00233 PD-1 Protein, Canine, Recombinant (hFc)

programmed cell death 1

Canine HEK293
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPY-05295 PD-1 Protein, Cynomolgus, Recombinant (hFc & Avi), Biotinylated

programmed cell death 1

Cynomolgus HEK293
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPY-01442 DMBT1 Protein, Human, Recombinant (His)

GP340,deleted in malignant brain tumors 1,...

Human HEK293
Deleted in malignant brain tumors 1 protein, also known as glycoprotein 34, surfactant pulmonary-associated D-binding protein, DMBT1 and GP34, is a secreted protein which belongs to theDMBT1 family. DMBT1 contains 2CUB domains, 14SRCR domains and 1ZP domain. It is highly expressed in alveolar and macrophage tissues. In some macrophages, expression is detected on the membrane, and in other macrophages, it is strongly expressed in the phagosome/phagolysosome compartments. Defects in DMBT1 are invo...
TMPY-02011 CD96 Protein, Human, Recombinant (His)

CD96 molecule,TACTILE

Human HEK293
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins d...
TMPY-02096 TACI Protein, Human, Recombinant (His)

RYZN,IGAD2,CVID,TACI,TNFRSF14B,CVID2,tumor...

Human HEK293
Tumor necrosis factor receptor superfamily, member 13B (TNFRSF13B) also known as Transmembrane activator and CAML interactor (TACI) and CD267 antigen, is a member of the tumor necrosis factor receptor superfamily. TNFRSF13B is a trimeric cytokine receptor that binds tumor necrosis factors (TNF). The receptor cooperates with an adaptor protein which is important in determining the outcome of the response. Members of the TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adapt...
TMPY-01613 Periostin/OSF-2 Protein, Mouse, Recombinant (His)

A630052E07Rik,OSF-2,Osf2,PLF,AI74...

Mouse HEK293
Periostin ( POSTN ), also known as OSF2 (osteoblast specific factor 2), is a heterofunctional secreted extracellular matrix (ECM) protein comprised of four fasciclin domains that promotes cellular adhesion and movement, as well as collagen fibrillogenesis. Postn is expressed in unique growth centers during embryonic development where it facilitates epithelial-mesenchymal transition (EMT) of select cell populations undergoing reorganization. In the adult, Postn expression is specifically induced ...
TMPY-01717 VEGF164 Protein, Mouse, Recombinant

vascular endothelial growth factor A,Vpf,Vegf,血管内皮生长因子

Mouse Baculovirus-Insect Cells
Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family and often exists as a disulfide-linked homodimer. VEGF-A protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular per...
TMPY-00341 FGFR3 Protein, Human, Recombinant (alpha IIIb, His)

CEK2,HSFGFR3EX,fibroblast growth factor receptor 3,...

Human HEK293
FGFR3, also known as CD333, is a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. FGFRs are transmembrane catalytic receptors that have intracellular tyrosine kinase activity. Mutations in FGFR genes are the cause of several human developmental disorders characterized by skeletal abnormalitie...
TMPY-00891 Neuropilin-1 Protein, Human, Recombinant (V179A, hFc)

neuropilin 1,VEGF165R,CD304,NP1,Neuropilin...

Human HEK293
Neuropilin is a type I transmembrane protein and the molecular mass is 120 kDa. Two homologs, Neuropilin-1 and Neuropilin-2, are identified. The primary structure of Neuropilin-1 and Neuropilin-2 is well conserved and is divided into four domains, CUB (a1/a2) domain, FV/FVIII (b1/b2) domain, MAM (c) domain, and (d) domain that contains a transmembrane and a short cytoplasmic region. Neuropilin-1 (NRP1) acts as a receptor for two different extracellular ligands, class 3 semaphorins, and specific ...
TMPY-04113 KRAS Protein,Human,Recombinant(G12D & Q61H, His)

Kirsten rat sarcoma viral oncogene homolog,KRAS2,KI...

Human E. coli
K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes because of the presence of an isoprenyl group on its C-terminus. K-Ras functions as a molecular on/off switch. Once it is turned on it recruits and activates proteins necessary for the propagation of growth factor and other receptors' signal, such as c-Raf and PI 3-kinase. It binds ...
TMPJ-00850 ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His)

Protein T1,suppression of tumorigenicity 2...

Mouse Human Cells
ST2, also called IL-1 R4, is an Interleukin-1 receptor family glycoprotein that plays a role in Th2 immune responses. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes. This receptor is very similar to the IL-1 receptor type I and the IL-18 receptor α chain in that ST2 also has three extracellular Ig domains and an intracellular Toll domain. ST2 binds IL-33, enhances inflammatory cytokines by activating nuclear factor-κB (NF-κB) and mitogen act...
TMPY-00633 PD-1 Protein, Rhesus, Recombinant (hFc)

programmed cell death 1

Rhesus HEK293
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPY-00250 PD-1 Protein, Rhesus, Recombinant (His)

programmed cell death 1

Rhesus HEK293
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPY-03717 PD-1 Protein, Rat, Recombinant (hFc)

programmed cell death 1

Rat HEK293
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPY-03074 Nicastrin Protein, Mouse, Recombinant (hFc)

Aph2,AA727311,Nct,NCSTN,nicastrin...

Mouse HEK293
Nicastrin (NCST, or NCT), a single-pass membrane glycoprotein that harbors a large extracellular domain, is an essential component of the gamma-secretase complex. Several lines of evidence indicate that the members of these complexes could also contribute to the control of cell death. NCT controls cell death via phosphoinositide 3-kinase/Akt and p53-dependent pathways and that this function remains independent of the activity and molecular integrity of the gamma-secretase complexes. Increasing p...
TMPY-02910 Nicastrin Protein, Mouse, Recombinant (His)

AA727311,NCSTN,Aph2,9430068N19Rik,Kiaa0

Mouse HEK293
Nicastrin (NCST, or NCT), a single-pass membrane glycoprotein that harbors a large extracellular domain, is an essential component of the gamma-secretase complex. Several lines of evidence indicate that the members of these complexes could also contribute to the control of cell death. NCT controls cell death via phosphoinositide 3-kinase/Akt and p53-dependent pathways and that this function remains independent of the activity and molecular integrity of the gamma-secretase complexes. Increasing p...
TMPY-00253 PD-1 Protein, Cynomolgus, Recombinant (hFc)

programmed cell death 1

Cynomolgus HEK293
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPY-06682 PD-1 Protein, Human, Recombinant (Asp26-Pro39 deletion, His)

hPD-1,hSLE1,hPD-l,CD279,PD1,PD-1,programmed cell de...

Human HEK293
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPY-05619 PD-1 Protein, Human, Recombinant (His), Biotinylated

hPD-l,PD-1,SLEB2,PD1,hPD-1,programmed cell death 1,...

Human HEK293
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPY-04967 PD-1 Protein, Mouse, Recombinant (His), Biotinylated

PD-1,programmed cell death 1,Ly101,Pdc1

Mouse HEK293
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
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重组蛋白

ULBP-2 Protein, Human, Recombinant (His)
Cat.No: TMPY-02333
Species: Human
Expression System: HEK293
ULBP-2 Protein, Human, Recombinant(aa 1-217, His&AVI),Biotinylated
Cat.No: TMPY-05592
Species: Human
Expression System: HEK293
G-CSF Protein, Human, Recombinant
Cat.No: TMPY-04829
Species: Human
Expression System: HEK293
Cripto Protein, Human, Recombinant (His)
Cat.No: TMPY-01413
Species: Human
Expression System: HEK293
PD-1 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPY-05260
Species: Cynomolgus
Expression System: HEK293
PD-1 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-00996
Species: Mouse
Expression System: HEK293
PD-1 Protein, Canine, Recombinant (His)
Cat.No: TMPY-04342
Species: Canine
Expression System: HEK293
PD-1 Protein, Human, Recombinant (mFc)
Cat.No: TMPY-05079
Species: Human
Expression System: HEK293
PD-1 Protein, Human, Recombinant (His)
Cat.No: TMPY-00897
Species: Human
Expression System: HEK293
PD-1 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPY-05395
Species: Mouse
Expression System: HEK293
PD-1 Protein, Canine, Recombinant (His & Avi), Biotinylated
Cat.No: TMPY-05815
Species: Canine
Expression System: HEK293
PD-1 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-04898
Species: Human
Expression System: HEK293
G-CSF Protein, Mouse, Recombinant
Cat.No: TMPY-05636
Species: Mouse
Expression System: HEK293
B7-H7 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-01263
Species: Cynomolgus
Expression System: HEK293
ULBP-2 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-02334
Species: Human
Expression System: HEK293
G-CSF Protein, Human, Recombinant (hFc)
Cat.No: TMPY-00813
Species: Human
Expression System: HEK293
PIP4K2A Protein, Human, Recombinant (His)
Cat.No: TMPJ-00978
Species: Human
Expression System: Human Cells
IL-22RA1 Protein, Rat, Recombinant (hFc)
Cat.No: TMPY-04286
Species: Rat
Expression System: HEK293
IL-22RA1 Protein, Canine, Recombinant (His)
Cat.No: TMPY-04087
Species: Canine
Expression System: HEK293
IL-22RA1 Protein, Rat, Recombinant (His)
Cat.No: TMPY-04287
Species: Rat
Expression System: HEK293
IL-22RA1 Protein, Canine, Recombinant (hFc)
Cat.No: TMPY-04002
Species: Canine
Expression System: HEK293
Cripto Protein, Rat, Recombinant (His)
Cat.No: TMPY-03908
Species: Rat
Expression System: HEK293
Cripto Protein, Human, Recombinant (hFc)
Cat.No: TMPY-05503
Species: Human
Expression System: HEK293
Cripto Protein, Rat, Recombinant (hFc)
Cat.No: TMPY-02679
Species: Rat
Expression System: HEK293
EIF5A2 Protein, Human, Recombinant (His)
Cat.No: TMPY-03795
Species: Human
Expression System: E. coli
GRK2 Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-04562
Species: Human
Expression System: Baculovirus-Insect Cells
ANGPTL1 Protein, Canine, Recombinant (hFc)
Cat.No: TMPY-04084
Species: Canine
Expression System: HEK293
PD-1 Protein, Human, Recombinant (hFc & Avi), Biotinylated
Cat.No: TMPY-06336
Species: Human
Expression System: HEK293
PD-1 Protein, Human, Recombinant (His & hFc)
Cat.No: TMPY-00896
Species: Human
Expression System: HEK293
PD-1 Protein, Rat, Recombinant (His)
Cat.No: TMPY-04341
Species: Rat
Expression System: HEK293
PD-1 Protein, Canine, Recombinant (hFc)
Cat.No: TMPY-00233
Species: Canine
Expression System: HEK293
PD-1 Protein, Cynomolgus, Recombinant (hFc & Avi), Biotinylated
Cat.No: TMPY-05295
Species: Cynomolgus
Expression System: HEK293
DMBT1 Protein, Human, Recombinant (His)
Cat.No: TMPY-01442
Species: Human
Expression System: HEK293
CD96 Protein, Human, Recombinant (His)
Cat.No: TMPY-02011
Species: Human
Expression System: HEK293
TACI Protein, Human, Recombinant (His)
Cat.No: TMPY-02096
Species: Human
Expression System: HEK293
Periostin/OSF-2 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-01613
Species: Mouse
Expression System: HEK293
VEGF164 Protein, Mouse, Recombinant
Cat.No: TMPY-01717
Species: Mouse
Expression System: Baculovirus-Insect Cells
FGFR3 Protein, Human, Recombinant (alpha IIIb, His)
Cat.No: TMPY-00341
Species: Human
Expression System: HEK293
Neuropilin-1 Protein, Human, Recombinant (V179A, hFc)
Cat.No: TMPY-00891
Species: Human
Expression System: HEK293
KRAS Protein,Human,Recombinant(G12D & Q61H, His)
Cat.No: TMPY-04113
Species: Human
Expression System: E. coli
ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His)
Cat.No: TMPJ-00850
Species: Mouse
Expression System: Human Cells
PD-1 Protein, Rhesus, Recombinant (hFc)
Cat.No: TMPY-00633
Species: Rhesus
Expression System: HEK293
PD-1 Protein, Rhesus, Recombinant (His)
Cat.No: TMPY-00250
Species: Rhesus
Expression System: HEK293
PD-1 Protein, Rat, Recombinant (hFc)
Cat.No: TMPY-03717
Species: Rat
Expression System: HEK293
Nicastrin Protein, Mouse, Recombinant (hFc)
Cat.No: TMPY-03074
Species: Mouse
Expression System: HEK293
Nicastrin Protein, Mouse, Recombinant (His)
Cat.No: TMPY-02910
Species: Mouse
Expression System: HEK293
PD-1 Protein, Cynomolgus, Recombinant (hFc)
Cat.No: TMPY-00253
Species: Cynomolgus
Expression System: HEK293
PD-1 Protein, Human, Recombinant (Asp26-Pro39 deletion, His)
Cat.No: TMPY-06682
Species: Human
Expression System: HEK293
PD-1 Protein, Human, Recombinant (His), Biotinylated
Cat.No: TMPY-05619
Species: Human
Expression System: HEK293
PD-1 Protein, Mouse, Recombinant (His), Biotinylated
Cat.No: TMPY-04967
Species: Mouse
Expression System: HEK293
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