Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Vonoprazan Fumarate (TAK438) 是质子泵的有效抑制剂,是口服有效的高效钾竞争性酸阻断剂,具有抗分泌活性。在 pH 为 6.5 时,它抑制猪胃微粒体中的 H+,K+-ATPase 酶活性,IC50为 19 nM。它被开发用于研究酸相关疾病,如消化性溃疡和胃食管反流病。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 294 | 现货 | ||
50 mg | ¥ 393 | 现货 | ||
100 mg | ¥ 527 | 现货 | ||
500 mg | ¥ 1,643 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 387 | 现货 |
产品描述 | Vonoprazan Fumarate (TAK438) , a novel potassium-competitive acid blocker, inhibits gastric acid secretion. Vonoprazan Fumarate (TAK438) inhibited H+,K+-ATPase activity in porcine gastric microsomes with IC50 value of 19 nM at pH 6.5. |
靶点活性 | H+, K+-ATPase:19 nM |
体外活性 | The inhibitory activity of Vonoprazan Fumurate was unaffected by ambient pH. The inhibition by Vonoprazan Fumurate was reversible and achieved in a K(+)-competitive manner, quite different from that by lansoprazole. Vonoprazan Fumurate exhibits porcine gastric H+ ,K+-ATPase activity in a concentration-dependent manner[4]. |
体内活性 | Vonoprazan Fumurate, at a dose of 4 mg/kg (as the free base) orally, completely inhibited basal and 2-deoxy-d-glucose-stimulated gastric acid secretion in rats, and its effect on both was stronger than that of lansoprazole. Vonoprazan Fumurate increased the pH of gastric perfusate to a higher value than did lansoprazole or SCH28080, and the effect of Vonoprazan Fumurate was sustained longer than that of lansoprazole or SCH28080[4]. |
别名 | TAK-438, TAK 438, Vonoprazan Fumurate, TAK438, 富马酸沃诺拉赞 |
分子量 | 461.46 |
分子式 | C21H20FN3O6S |
CAS No. | 881681-01-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.61 mg/mL (10 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.167 mL | 10.8352 mL | 21.6704 mL | 54.1759 mL |
5 mM | 0.4334 mL | 2.167 mL | 4.3341 mL | 10.8352 mL | |
10 mM | 0.2167 mL | 1.0835 mL | 2.167 mL | 5.4176 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Vonoprazan Fumarate 881681-01-2 Membrane transporter/Ion channel Proton pump peptic potassium TAK-438 secretion reflux competitive TAK 438 proton inhibitor antisecretory disease gastroesophageal Vonoprazan Fumurate inhibit Vonoprazan ulcer GERD blocker acid gastric TAK438 pump P-CAB Proton Pump 富马酸沃诺拉赞 Inhibitor