Reserpine (Serpalan) is an alkaloid isolated from the root of Rauwolfia serpentina. As an inhibitor of vesicular monoamine transporter 2 (VMAT2), it suppresses the uptake of norepinephrine into storage vesicles, leading to depletion of catecholamines and serotonin in central and peripheral nerve terminals. It has antihypertensive and antipsychotic effects and can be used to induce gastric ulcer and depression models.

与对照组相比,隔日注射利血平注射液（1 mg/kg s.c.）3天导致大鼠空泡咀嚼,舌头突出和面部抽搐持续时间显着增加.Reserpine造成大鼠的皮质部分谷氨酸摄取降低.Reserpine引起大鼠正中隆起的血管加压素/催产素 - 神经生长素样免疫反应性（LI）和CRH-L1显著消耗.Reserpine显著恢复了猴子延迟应答任务的表现.5 mg/kg Reserpine在猴子中,明显增加无效颚运动,并且还减少大鼠在所有年龄组的饲养行为.在完整大鼠中皮下注射5 mg/kg Reserpine,降低细胞外多巴胺水平至基础值的4％.Reserpine对视觉辨别的任务的表现影响甚微,这是一项不依赖前额叶皮层的参考记忆任务.

Reserpine在11,21和48个所测试的102无关的临床分离株中,抑制外排泵,将施怕沙星,莫西沙星和环丙沙星的IC50值和MICs降低4倍。