reserpine

Reserpine (Serpalan) 是一种从催吐萝芙木的根中发现的生物碱。它抑制去甲肾上腺素吸收到储存囊泡中，导致中枢和外周轴突末端的儿茶酚胺和血清素耗尽。它可作为抗高血压药和抗精神病药以及研究工具。

Deserpidine (Harmonyl) 是从 Rauwolfia canescens 的根中分离的生物碱。Deserpidine 与 Reserpine 相关。Deserpidine 是竞争性血管紧张素转化酶抑制剂，可以被用作抗高血压药以及镇定剂。Deserpidine 还减少了肾上腺皮质血管紧张素 II 诱导的醛固酮分泌。

Reserpine hydrochloride（利血平盐酸盐）是Reserpine的盐形式。Reserpine是一种生物碱，抑制去甲肾上腺素吸收到储存囊泡中，导致中枢和外周轴突末端的儿茶酚胺和血清素耗尽，具有抗高血压和抗精神病的潜力。

Reserpine-d9 是 Reserpine 的氘代化合物。Reserpine 的 CAS 号为 50-55-5。Reserpine 是一种从催吐萝芙木的根中发现的生物碱。它抑制去甲肾上腺素吸收到储存囊泡中，导致中枢和外周轴突末端的儿茶酚胺和血清素耗尽。它可作为抗高血压药和抗精神病药以及研究工具。

Bishomoreserpine is a reserpine analog with a potent inhibitory.

Bromoreserpine 是 reserpine的类似物。

Dibromoreserpine is a biochemical.

Isoreserpine is a biochemical.

L-5-Hydroxytryptophan (L-5-HTP) 是一种天然氨基酸和膳食补充剂，可以用作抗抑郁剂、食欲抑制剂和睡眠辅助剂，是神经递质血清素的前体，是利血平(reserpine) 的拮抗剂。它能够用于肌阵挛、纤维肌痛症、偏头痛和小脑共济失调的研究。

Biperiden (Bipariden) 是中枢 M1胆碱受体阻断剂，有抗帕金森症活性。

Calligonine，也称作Tetrahydroharman，是Calligonum minimum的根部和Elaeagnus angustifolia的树皮中的主要生物碱成分。内服时，该化合物能显著降低血压，并且效果持续较长时间，其作用与reserpine相似。

ASP8477是一种高效且选择性的FAAH抑制剂。该化合物通过口服活性能增加大脑中的阿纳米酰胺（anandamide）水平。在大鼠的神经病理性及骨关节炎疼痛模型中，ASP8477显示出良好的疗效，且不引起运动协调障碍。单次口服ASP8477能改善慢性压迫性神经损伤大鼠的热性痛觉过敏和寒冷痛觉异常。此外，ASP8477还能恢复由利血平引起的肌肉压力阈值下降的肌痛大鼠模型。研究表明，ASP8477在缓解神经病理性和功能性疼痛方面具有镇痛效果，其药理特性适合用于治疗慢性疼痛。

ASM-IN-3 (Compound 21b) 是一种选择性且能穿透血脑屏障的acid sphingomyelinase (ASM)抑制剂，其对纯化的人ASM的IC50为3.37 μM。ASM-IN-3 通过抑制海马区的ASM活性并促进神经发生，改善Reserpine诱导的抑郁大鼠的抑郁样行为。

KF 392 is antiulcer. It was found that KF-392 given orally to rats at 1.0 to 5.0 mg kg had a marked suppression on the developments of Shay ulcer as well as the aspirin-, stress-, and reserpine-induced gastric lesions.

Yohimbic acid, ethyl ester is a biochemical with possible effects on reserpine action.

Perafensine is a drug which was investigated as an antidepressant but was never marketed. It has been reported to antagonize the effects of reserpine and to inhibit the reuptake of norepinephrine (norepinephrine reuptake inhibitor); whether it also affects the reuptake of serotonin or dopamine is unclear

Deserpidine hydrochloride is the salf form of Deserpidine (free base), which is an antihypertensive drug related to reserpine which occurs naturally in Rauwolfia canescens. Deserpidine is a competitive inhibitor of the angiotensin converting enzyme (ACE). By competing with angiotensin I for ACE, deserpidine blocks the conversion of angiotensin I to angiotensin II, which is a potent vasoconstrictor. Reduced level of serum angiotensin II causes a decrease in blood pressure. Deserpidine also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex.

(±)-N-desmethyl Venlafaxine, a minor active metabolite of venlafaxine, serves as a selective norepinephrine and serotonin reuptake inhibitor (SNRI). Generated through the metabolization by the cytochrome P450 (CYP) isoform CYP3A4, it exhibits reuptake inhibition of norepinephrine and serotonin in rat synaptosome preparations, demonstrated by IC50 values of 4.7 and 1.6 µM, respectively. Clinically, it has been shown to counteract reserpine-induced hypothermia in mice, displaying efficacy at a minimum effective dose (MED) of 10 mg kg.

OPC 4392 hydrochloride 作为突触前多巴胺受体 (dopamine receptor) 的激动剂以及突触后D2受体的拮抗剂，具有显著的生物活性。该化合物能有效逆转由Reserpine引起的多巴胺积累，并在Apomorphine诱导的小鼠模型中抑制刻板行为和攀爬行为。

Isopimaric acid is active against MDR and MRSA strains of S. aureus which are becoming increasingly resistant to antibiotics, the minimum inhibitory concentrations (MIC) are 32-64 microg mL . Isopimaric acid is also possible that an antagonistic interacti