Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Doxazosin (UK 33274) 是选择性的拮抗突触后的α1肾上腺素受体。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 279 | 现货 | ||
10 mg | ¥ 393 | 现货 | ||
25 mg | ¥ 659 | 现货 | ||
50 mg | ¥ 979 | 现货 | ||
100 mg | ¥ 1,470 | 现货 | ||
200 mg | ¥ 2,270 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 349 | 现货 |
产品描述 | Doxazosin (UK 33274) is a long-lasting inhibitor of α1-adrenoceptors that is widely used to treat benign prostatic hyperplasia and lower urinary tract symptoms. |
体外活性 | Doxazosin, at concentrations of 5-20 mumol/L, increased LDL binding to hepatic cells in a dose-related manner. Also, in these hepatic cells, doxazosin produced dose-related decreases in both newly synthesized cholesterol and cholesterol ester. In rabbit fibroblasts that were LDL receptor negative, de novo cholesterol synthesis was markedly reduced by increasing concentrations of doxazosin. Taken together, these results suggest that doxazosin may have a direct inhibitory effect on cholesterol synthesis independent of the LDL receptor[2]. |
体内活性 | Both the enantiomers were highly bound to the plasma proteins of rats, dogs and humans [(-)doxazosin: 89.4%-94.3%; (+)doxazosin: 90.9%-95.4%]. (+)Doxazosin exhibited significantly higher protein binding capacities than (-)doxazosin in all the three species, and the difference in the bound concentration (Cb) between the two enantiomers was enhanced as their concentrations were increased. Although the percentage of the plasma protein binding in the dog plasma was significantly lower than that in the human plasma at 400 and 800 ng/mL, the corrected percentage of plasma protein binding was dog>human>rat[3]. |
别名 | UK 33274, 多沙唑嗪 |
分子量 | 451.48 |
分子式 | C23H25N5O5 |
CAS No. | 74191-85-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.5 mg/ml (60.91 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.2149 mL | 11.0747 mL | 22.1494 mL | 55.3734 mL |
5 mM | 0.443 mL | 2.2149 mL | 4.4299 mL | 11.0747 mL | |
10 mM | 0.2215 mL | 1.1075 mL | 2.2149 mL | 5.5373 mL | |
20 mM | 0.1107 mL | 0.5537 mL | 1.1075 mL | 2.7687 mL | |
50 mM | 0.0443 mL | 0.2215 mL | 0.443 mL | 1.1075 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Doxazosin 74191-85-8 GPCR/G Protein Neuroscience Adrenergic Receptor inhibit UK33274 Inhibitor Beta Receptor UK 33274 多沙唑嗪 UK-33274 inhibitor