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HIF

HIF

Hypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) that is encoded by the HIF1A gene. It is a basic helix-loop-helix PAS domain containing protein, and is considered as the master transcriptional regulator of cellular and developmental response to hypoxia. The dysregulation and overexpression of HIF1A by either hypoxia or genetic alternations have been heavily implicated in cancer biology, as well as a number of other pathophysiologies, specifically in areas of vascularization and angiogenesis, energy metabolism, cell survival, and tumor invasion. Two other alternative transcripts encoding different isoforms have been identified.
TargetMol
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Cat. No. Product Name CAS No. Purity Chemical Structure
T3197 Daprodustat
化合物Daprodustat
960539-70-2 98.81%
TargetMol Chemical Structure Daprodustat
Daprodustat 是一种口服具有活力的缺氧诱导因子脯氨酰羟化酶 (HIFPH) 抑制剂,可用于与慢性肾病相关的贫血病的研究。
T13402 ZK-261991
化合物 T13402
886563-25-3 98%
TargetMol Chemical Structure ZK-261991
ZK-261991 is an orally active inhibitor of VEGFR tyrosine kinase(IC50 of 5 nM, VEGFR2).
TN4603 Myricanol
化合物 TN4603
33606-81-4 98%
TargetMol Chemical Structure Myricanol
Myricanol can elicit growth inhibitory and cytotoxic effects on lung cancer cells, it can significantly decelerate tumor growth in vivo by inducing apoptosis.
T12675 (Rac)-PT2399
化合物 T12675
1672662-07-5 98%
TargetMol Chemical Structure (Rac)-PT2399
(Rac)-PT2399 is a potent and specific inhibitor of hypoxia-inducible factor 2a (HIF-2α)(IC50 of 0.01 μM).
TN5250 Vomifoliol
化合物 TN5250
23526-45-6 98%
TargetMol Chemical Structure Vomifoliol
Vomifoliol is most likely the immediate precursor of dehydrovomifoliol, because of the organism converted abscisic acid (ABA), to dehydrovomifoliol as the major ...
TN4489 Manassantin A
化合物 TN4489
88497-87-4 98%
TargetMol Chemical Structure Manassantin A
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
T15234 ENMD-1198
化合物 T15234
864668-87-1 98%
TargetMol Chemical Structure ENMD-1198
ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF-1α and STAT3 in human HCC cells.
T10258 AFP464 free base
化合物 T10258
468719-52-0 98%
TargetMol Chemical Structure AFP464 free base
AFP464 (NSC710464) free base is an active HIF-1α inhibitor (IC50: 0.25 μM) and a potent aryl hydrocarbon receptor (AhR) activator.
TN1952 Moracin P
桑辛素P
102841-46-3 98%
TargetMol Chemical Structure Moracin P
Moracin P exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tum...
T6804 Chetomin
化合物Chetomin
1403-36-7 98%
TargetMol Chemical Structure Chetomin
Chetomin (BRN0077366) 是球毛壳菌的活性成分,是一种无毒的非小细胞肺癌干细胞靶向分子。它是一种热休克蛋白90/缺氧诱导因子1α 途径的抑制剂。
T36439 Gramicidin A
杀螨素A
11029-61-1 98%
TargetMol Chemical Structure Gramicidin A
Gramicidin A 是一种从从 B. brevis 分离出来的多肽类抗生素。Gramicidin A 是一种高度疏水的通道形成离子载体,在人工膜中形成一价阳离子可渗透的通道。Gramicidin A 诱导缺氧诱导因子 1α (HIF-1α) 的降解,并能降低人肾细胞癌小鼠异种移植模型的生长。Gramicidin ...
TN2040 Panaxynol
人参炔醇
81203-57-8 98%
TargetMol Chemical Structure Panaxynol
Panaxynol is the most potent antiplatelet agent in ginseng and its mechanism of action is chiefly due to the inhibition of thromboxane formation.
TN1951 Moracin O
桑辛素O
123702-97-6 98%
TargetMol Chemical Structure Moracin O
Moracin O shows significant neuroprotective, and analgesic activities, it also has a strong protective influence against doxorubicin-induced cardiomyopathy in H9...
T2309 Ganetespib
化合物Ganetespib
888216-25-9 99.95%
TargetMol Chemical Structure Ganetespib
Ganetespib (STA-9090) 是一种热休克蛋白 90 抑制剂,通过抑制 HIF-1α 和 STAT3 对大肠癌具有抗血管生成作用。它还具有细胞毒性。
T2220 2-Methoxyestradiol
二甲氧基雌二醇
362-07-2 99.95%
TargetMol Chemical Structure 2-Methoxyestradiol
2-Methoxyestradiol (2-ME2) 是一种口服生物可利用的雌二醇代谢物,具有抗肿瘤活性。它通过减少内皮细胞增殖和诱导内皮细胞凋亡来抑制血管生成,也可破坏微管的稳定。它可诱导半胱天冬酶活化,导致细胞周期停滞在 G2 期、DNA 断裂和细胞凋亡。
T2515 Roxadustat
罗沙司他
808118-40-3 99.94%
TargetMol Chemical Structure Roxadustat
Roxadustat (FG-4592) 是一种口服生物可利用的缺氧诱导因子脯氨酰羟化酶抑制剂,通过增加内源性促红细胞生成素、改善铁调节和降低铁调素来促进红细胞生成,具有潜在的抗贫血活性。
T13398 ZINC13466751
化合物ZINC13466751
117953-17-0 99.94%
TargetMol Chemical Structure ZINC13466751
ZINC13466751 是有效的 HIF-1α/von Hippel-Lindau 相互作用抑制剂,抑制作用的 IC50为 2.0 µM。
T5740 25(R,S)-Ruscogenin
(25RS)鲁斯可皂苷元
874485-32-2 99.89%
TargetMol Chemical Structure 25(R,S)-Ruscogenin
25(R,S)-Ruscogenin 能够调节 PI3K/Akt/mTOR 信号通路,抑制 MMP-2、MMP-9、uPA、VEGF 和 HIF-1α 的表达,阻碍肝癌转移。 它能够抑制 TLR4信号通路,减轻 LPS 诱导的肺内皮细胞凋亡。
TN1480 Cephaeline
吐根酚碱
483-17-0 99.88%
TargetMol Chemical Structure Cephaeline
Cephaeline 对受保护的原代 CLL 细胞具有高度活性(相对 IC50 为 35nM),并通过抑制 HIF-1α± 和扰乱细胞内氧化还原稳态发挥作用。
T2389 Dapagliflozin
达格列净
461432-26-8 99.74%
TargetMol Chemical Structure Dapagliflozin
Dapagliflozin (BMS-512148) 是一种葡萄糖协同转运蛋白2 (SGLT2) 抑制剂,可与靶点竞争性结合。Dapagliflozin 可用于 2 型糖尿病的治疗,可以减少肾脏的葡萄糖重吸收,增加尿液中葡萄糖的排泄,从而降低血浆葡萄糖水平。
Daprodustat
T3197
Daprodustat 是一种口服具有活力的缺氧诱导因子脯氨酰羟化酶 (HIFPH) 抑制剂,可用于与慢性肾病相关的贫血病的研究。
ZK-261991
T13402
ZK-261991 is an orally active inhibitor of VEGFR tyrosine kinase(IC50 of 5 nM, VEGFR2).
Myricanol
TN4603
Myricanol can elicit growth inhibitory and cytotoxic effects on lung cancer cells, it can significantly decelerate tumor growth in vivo by inducing apoptosis.
(Rac)-PT2399
T12675
(Rac)-PT2399 is a potent and specific inhibitor of hypoxia-inducible factor 2a (HIF-2α)(IC50 of 0.01 μM).
Vomifoliol
TN5250
Vomifoliol is most likely the immediate precursor of dehydrovomifoliol, because of the organism converted abscisic acid (ABA), to dehydrovomifoliol as the major ...
Manassantin A
TN4489
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
ENMD-1198
T15234
ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF-1α and STAT3 in human HCC cells.
AFP464 free base
T10258
AFP464 (NSC710464) free base is an active HIF-1α inhibitor (IC50: 0.25 μM) and a potent aryl hydrocarbon receptor (AhR) activator.
Moracin P
TN1952
Moracin P exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tum...
Chetomin
T6804
Chetomin (BRN0077366) 是球毛壳菌的活性成分,是一种无毒的非小细胞肺癌干细胞靶向分子。它是一种热休克蛋白90/缺氧诱导因子1α 途径的抑制剂。
Gramicidin A
T36439
Gramicidin A 是一种从从 B. brevis 分离出来的多肽类抗生素。Gramicidin A 是一种高度疏水的通道形成离子载体,在人工膜中形成一价阳离子可渗透的通道。Gramicidin A 诱导缺氧诱导因子 1α (HIF-1α) 的降解,并能降低人肾细胞癌小鼠异种移植模型的生长。Gramicidin ...
Panaxynol
TN2040
Panaxynol is the most potent antiplatelet agent in ginseng and its mechanism of action is chiefly due to the inhibition of thromboxane formation.
Moracin O
TN1951
Moracin O shows significant neuroprotective, and analgesic activities, it also has a strong protective influence against doxorubicin-induced cardiomyopathy in H9...
Ganetespib
T2309
Ganetespib (STA-9090) 是一种热休克蛋白 90 抑制剂,通过抑制 HIF-1α 和 STAT3 对大肠癌具有抗血管生成作用。它还具有细胞毒性。
2-Methoxyestradiol
T2220
2-Methoxyestradiol (2-ME2) 是一种口服生物可利用的雌二醇代谢物,具有抗肿瘤活性。它通过减少内皮细胞增殖和诱导内皮细胞凋亡来抑制血管生成,也可破坏微管的稳定。它可诱导半胱天冬酶活化,导致细胞周期停滞在 G2 期、DNA 断裂和细胞凋亡。
Roxadustat
T2515
Roxadustat (FG-4592) 是一种口服生物可利用的缺氧诱导因子脯氨酰羟化酶抑制剂,通过增加内源性促红细胞生成素、改善铁调节和降低铁调素来促进红细胞生成,具有潜在的抗贫血活性。
ZINC13466751
T13398
ZINC13466751 是有效的 HIF-1α/von Hippel-Lindau 相互作用抑制剂,抑制作用的 IC50为 2.0 µM。
25(R,S)-Ruscogenin
T5740
25(R,S)-Ruscogenin 能够调节 PI3K/Akt/mTOR 信号通路,抑制 MMP-2、MMP-9、uPA、VEGF 和 HIF-1α 的表达,阻碍肝癌转移。 它能够抑制 TLR4信号通路,减轻 LPS 诱导的肺内皮细胞凋亡。
Cephaeline
TN1480
Cephaeline 对受保护的原代 CLL 细胞具有高度活性(相对 IC50 为 35nM),并通过抑制 HIF-1α± 和扰乱细胞内氧化还原稳态发挥作用。
Dapagliflozin
T2389
Dapagliflozin (BMS-512148) 是一种葡萄糖协同转运蛋白2 (SGLT2) 抑制剂,可与靶点竞争性结合。Dapagliflozin 可用于 2 型糖尿病的治疗,可以减少肾脏的葡萄糖重吸收,增加尿液中葡萄糖的排泄,从而降低血浆葡萄糖水平。
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