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HIF

HIF

Hypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) that is encoded by the HIF1A gene. It is a basic helix-loop-helix PAS domain containing protein, and is considered as the master transcriptional regulator of cellular and developmental response to hypoxia. The dysregulation and overexpression of HIF1A by either hypoxia or genetic alternations have been heavily implicated in cancer biology, as well as a number of other pathophysiologies, specifically in areas of vascularization and angiogenesis, energy metabolism, cell survival, and tumor invasion. Two other alternative transcripts encoding different isoforms have been identified.
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Cat. No. Product Name CAS No. Purity Chemical Structure
T11562 HIF-2α-IN-3
化合物 T11562
313964-19-1 98%
HIF-2α-IN-3 is an allosteric inhibitor of HIF-2α (IC50: 0.4 μM; KD: 1.1 μM) with anticancer activity.
T13402 ZK-261991
化合物 T13402
886563-25-3 98%
ZK-261991 is an orally active inhibitor of VEGFR tyrosine kinase(IC50 of 5 nM, VEGFR2).
TN4603 Myricanol
化合物 TN4603
33606-81-4 98%
Myricanol can elicit growth inhibitory and cytotoxic effects on lung cancer cells, it can significantly decelerate tumor growth in vivo by inducing apoptosis.
T12675 (Rac)-PT2399
化合物 T12675
1672662-07-5 98%
(Rac)-PT2399 is a potent and specific inhibitor of hypoxia-inducible factor 2a (HIF-2α)(IC50 of 0.01 μM).
TN5250 Vomifoliol
化合物 TN5250
23526-45-6 98%
Vomifoliol is most likely the immediate precursor of dehydrovomifoliol, because of the organism converted abscisic acid (ABA), to dehydrovomifoliol as the major ...
TN4489 Manassantin A
化合物 TN4489
88497-87-4 98%
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
T15234 ENMD-1198
化合物 T15234
864668-87-1 98%
ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF-1α and STAT3 in human HCC cells.
T10258 AFP464 free base
化合物 T10258
468719-52-0 98%
AFP464 (NSC710464) free base is an active HIF-1α inhibitor (IC50: 0.25 μM) and a potent aryl hydrocarbon receptor (AhR) activator.
TN1952 Moracin P
桑辛素P
102841-46-3 98%
Moracin P exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tum...
T6804 Chetomin
化合物Chetomin
1403-36-7 98%
Chetomin (BRN0077366) 是球毛壳菌的活性成分,是一种无毒的非小细胞肺癌干细胞靶向分子。它是一种热休克蛋白90/缺氧诱导因子1α 途径的抑制剂。
T36439 Gramicidin A
杀螨素A
11029-61-1 98%
Gramicidin A 是一种从从 B. brevis 分离出来的多肽类抗生素。Gramicidin A 是一种高度疏水的通道形成离子载体,在人工膜中形成一价阳离子可渗透的通道。Gramicidin A 诱导缺氧诱导因子 1α (HIF-1α) 的降解,并能降低人肾细胞癌小鼠异种移植模型的生长。Gramicidin ...
TN2040 Panaxynol
人参炔醇
81203-57-8 98%
Panaxynol is the most potent antiplatelet agent in ginseng and its mechanism of action is chiefly due to the inhibition of thromboxane formation.
TN1951 Moracin O
桑辛素O
123702-97-6 98%
Moracin O shows significant neuroprotective, and analgesic activities, it also has a strong protective influence against doxorubicin-induced cardiomyopathy in H9...
T2220 2-Methoxyestradiol
二甲氧基雌二醇
362-07-2 99.95%
2-Methoxyestradiol (2-ME2) 是一种口服生物可利用的雌二醇代谢物,具有抗肿瘤活性。它通过减少内皮细胞增殖和诱导内皮细胞凋亡来抑制血管生成,也可破坏微管的稳定。它可诱导半胱天冬酶活化,导致细胞周期停滞在 G2 期、DNA 断裂和细胞凋亡。
T13398 ZINC13466751
化合物ZINC13466751
117953-17-0 99.94%
ZINC13466751 是有效的 HIF-1α/von Hippel-Lindau 相互作用抑制剂,抑制作用的 IC50为 2.0 µM。
T5740 25(R,S)-Ruscogenin
(25RS)鲁斯可皂苷元
874485-32-2 99.89%
25(R,S)-Ruscogenin 能够调节 PI3K/Akt/mTOR 信号通路,抑制 MMP-2、MMP-9、uPA、VEGF 和 HIF-1α 的表达,阻碍肝癌转移。 它能够抑制 TLR4信号通路,减轻 LPS 诱导的肺内皮细胞凋亡。
T2389 Dapagliflozin
达格列净
461432-26-8 99.74%
Dapagliflozin (BMS-512148) 竞争性的葡萄糖协同转运蛋白2 (SGLT2) 抑制剂,可促进尿液中葡萄糖的排泄,在糖尿病 (DM) 研究中具有价值。Dapagliflozin 诱导 HIF1表达并减轻肾脏 IR 损伤。
T61822 M1002
化合物M1002
823830-85-9 99.73%
M1002 是一种缺氧诱导因子-2 (HIF-2) 激动剂,可以增强HIF-2alpha和ARNT对转录激活的亲和力 。M1002能够改变HIF-281alpha PAS-B结构域的Tyr2构象, 与脯氨酰羟化酶结构域 (PHD) 抑制剂可发挥协同作用。
T19832 Acriflavine Hydrochloride
盐酸吖啶黄
8063-24-9 99.69%
Acriflavine Hydrochloride (Acriflavine HCl) 是一种 HIF-1α 抑制剂。它通过靶向 HIF-1α 介导的途径并在体外和体内降低 PGK1、VEGF 和 HIF-1α 的水平发挥作用。
T124358 Deferoxamine
去铁胺
70-51-9 99.66%
Deferoxamine(Desferrioxamine B) 是一种铁螯合剂 (结合 Fe(III) 和许多其他金属阳离子),可抑制神经元病变,可用于改减少铁在组织中的积累和沉积,可通过抑制创伤性脑损伤后的铁死亡和神经炎症来改善神经功能障碍。Desferrioxamin-B 具有抗氧化、抗增殖、抗肿瘤活性,可诱导 HI...
HIF-2α-IN-3
T11562
HIF-2α-IN-3 is an allosteric inhibitor of HIF-2α (IC50: 0.4 μM; KD: 1.1 μM) with anticancer activity.
ZK-261991
T13402
ZK-261991 is an orally active inhibitor of VEGFR tyrosine kinase(IC50 of 5 nM, VEGFR2).
Myricanol
TN4603
Myricanol can elicit growth inhibitory and cytotoxic effects on lung cancer cells, it can significantly decelerate tumor growth in vivo by inducing apoptosis.
(Rac)-PT2399
T12675
(Rac)-PT2399 is a potent and specific inhibitor of hypoxia-inducible factor 2a (HIF-2α)(IC50 of 0.01 μM).
Vomifoliol
TN5250
Vomifoliol is most likely the immediate precursor of dehydrovomifoliol, because of the organism converted abscisic acid (ABA), to dehydrovomifoliol as the major ...
Manassantin A
TN4489
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
ENMD-1198
T15234
ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF-1α and STAT3 in human HCC cells.
AFP464 free base
T10258
AFP464 (NSC710464) free base is an active HIF-1α inhibitor (IC50: 0.25 μM) and a potent aryl hydrocarbon receptor (AhR) activator.
Moracin P
TN1952
Moracin P exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tum...
Chetomin
T6804
Chetomin (BRN0077366) 是球毛壳菌的活性成分,是一种无毒的非小细胞肺癌干细胞靶向分子。它是一种热休克蛋白90/缺氧诱导因子1α 途径的抑制剂。
Gramicidin A
T36439
Gramicidin A 是一种从从 B. brevis 分离出来的多肽类抗生素。Gramicidin A 是一种高度疏水的通道形成离子载体,在人工膜中形成一价阳离子可渗透的通道。Gramicidin A 诱导缺氧诱导因子 1α (HIF-1α) 的降解,并能降低人肾细胞癌小鼠异种移植模型的生长。Gramicidin ...
Panaxynol
TN2040
Panaxynol is the most potent antiplatelet agent in ginseng and its mechanism of action is chiefly due to the inhibition of thromboxane formation.
Moracin O
TN1951
Moracin O shows significant neuroprotective, and analgesic activities, it also has a strong protective influence against doxorubicin-induced cardiomyopathy in H9...
2-Methoxyestradiol
T2220
2-Methoxyestradiol (2-ME2) 是一种口服生物可利用的雌二醇代谢物,具有抗肿瘤活性。它通过减少内皮细胞增殖和诱导内皮细胞凋亡来抑制血管生成,也可破坏微管的稳定。它可诱导半胱天冬酶活化,导致细胞周期停滞在 G2 期、DNA 断裂和细胞凋亡。
ZINC13466751
T13398
ZINC13466751 是有效的 HIF-1α/von Hippel-Lindau 相互作用抑制剂,抑制作用的 IC50为 2.0 µM。
25(R,S)-Ruscogenin
T5740
25(R,S)-Ruscogenin 能够调节 PI3K/Akt/mTOR 信号通路,抑制 MMP-2、MMP-9、uPA、VEGF 和 HIF-1α 的表达,阻碍肝癌转移。 它能够抑制 TLR4信号通路,减轻 LPS 诱导的肺内皮细胞凋亡。
Dapagliflozin
T2389
Dapagliflozin (BMS-512148) 竞争性的葡萄糖协同转运蛋白2 (SGLT2) 抑制剂,可促进尿液中葡萄糖的排泄,在糖尿病 (DM) 研究中具有价值。Dapagliflozin 诱导 HIF1表达并减轻肾脏 IR 损伤。
M1002
T61822
M1002 是一种缺氧诱导因子-2 (HIF-2) 激动剂,可以增强HIF-2alpha和ARNT对转录激活的亲和力 。M1002能够改变HIF-281alpha PAS-B结构域的Tyr2构象, 与脯氨酰羟化酶结构域 (PHD) 抑制剂可发挥协同作用。
Acriflavine Hydrochloride
T19832
Acriflavine Hydrochloride (Acriflavine HCl) 是一种 HIF-1α 抑制剂。它通过靶向 HIF-1α 介导的途径并在体外和体内降低 PGK1、VEGF 和 HIF-1α 的水平发挥作用。
Deferoxamine
T124358
Deferoxamine(Desferrioxamine B) 是一种铁螯合剂 (结合 Fe(III) 和许多其他金属阳离子),可抑制神经元病变,可用于改减少铁在组织中的积累和沉积,可通过抑制创伤性脑损伤后的铁死亡和神经炎症来改善神经功能障碍。Desferrioxamin-B 具有抗氧化、抗增殖、抗肿瘤活性,可诱导 HI...
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