o-11

O-11 is an analog of the fully saturated, 14-carbon fatty acid myristic acid, in which the methylene group at position 11 is replaced with oxygen. It is highly effective and selective at killingTrypanosoma brucei, the protozoan parasite responsible for African sleeping sickness, exhibiting an LD50of less than 1 μM in a cell culture assay.1,2The toxic effects of O-11 appear to be caused by its ability to inhibit the incorporation of a single myristate into the GPI anchor of the variant surface glycoprotein (VSG), a protein critical for evading the host immune response.1O-11 exhibits essentially no anti-fungal activity when assayed usingC. neoformans, but does have a minor inhibitory effect on HIV-1 replication in T-lymphocytes.3 1.Doering, T.L., Raper, J., Buxbaum, L.U., et al.An analog of myristic acid with selective toxicity for African trypanosomesScience2521851-1854(1991) 2.Doering, T.L., Lu, T., Werbovetz, K.A., et al.Toxicity of myristic acid analogs toward African trypanosomesProceedings of the National Academy of Sciences of the United States of America919735-9739(1994) 3.Langner, C.A., Lodge, J.K., Travis, S.J., et al.4-Oxatetradecanoic acid is fungicidal for Cryptococcus neoformans and inhibits replication of human immunodeficiency virus IThe Journal of Biological Chemisty267(24)17159-17169(1992)

BIO-11006 acetate salt (901117-03-1 free base) 是一种多糖基化富含丙氨酸的 C 激酶底物 (MARCKS) 抑制剂，类似于 MANS 肽。

4,5-Dioxo-4,5-seco-11(13)-cadinen-12-oic acid 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125973。

BO-1158 is an antibacteria agent.

RO-11-7330 is a bioactive chemical.

Tetrahydro-11-deoxy cortisol (THS) is the primary urinary metabolite of 11-deoxycortisol. Urinary excretion of THS is elevated in patients with 11β-hydroxylase deficiency, a condition resulting from mutations in the cytochrome P450 (CYP) isoform CYP11B1. Urinary levels of THS are also elevated in patients with adrenocortical carcinoma (ACC) and adrenocortical adenoma (ACA) but are higher in patients with ACC compared to ACA.

10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65432，CAS号为 3159-07-7。

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65438，CAS号为 31251-41-9。

Tetrahydro-11-dehydrocorticosterone 是一种抑制11β-HSD（11β-羟类固醇脱氢酶）的化合物。

LASSBio-1135 是一种口服有效的 TRPV1 拮抗剂和 TNF-α 生成抑制剂。

Fos-Choline-ISO-11 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 TF0024，CAS号为 869647-65-4。

1,11b-Dihydro-11b-hydroxymaackiain is a natural product from Derris robusta.

1,11b-Dihydro-11b-hydroxymedicarpin is a natural product from Derris robusta.

BIO-11006抑制剂是一种气雾化的10-氨基酸肽类化合物，可抑制肌醇醛酰化丰富蛋白激酶C底物（MARCKS）蛋白，具有潜在的免疫调节和抗肿瘤活性。

Tiapamil hydrochloride (Ro 11-1781 hydrochloride) 是一种钙通道阻滞剂，具有抗高血压活性，可用于研究心绞痛和心血管疾病。

Mexiletine hydrochloride (KOE-1173 hydrochloride) 是一种电压门控钠通道阻滞剂，是 IB 类抗心律失常药。 Mexiletine hydrochloride 通过抑制心肌细胞内钠电流，从而降低心脏动作电位（0相）上升速率，并且降低浦肯野纤维的自律性而发挥抗心律失常作用。

5-Nitro-1,10-phenanthroline (5-NP) 是一种有效的杀菌剂，可抑制艰难梭菌。

Lipopolysaccharides, Escherichiacoli (E. coli O111:B4) 来源于大肠杆菌O111:B4， 是革兰氏阴性细菌细胞壁的一种特有成分，由脂质A、寡糖核心和 O -特异性多糖 (O-antigen) 3个区域组成。Lipopolysaccharides, Escherichiacoli 有利于维持细胞外膜的完整性，保护细菌免受胆汁盐和脂类抗生素的破坏。Lipopolysaccharides, Escherichiacoli 是一种高免疫原性抗原，可以增强免疫反应，可以用于炎症模型构建。

SHO1122147 (Compound 7m) 通过影响线粒体电子传递链展现出线粒体解偶联活性（EC50=3.6 μM），提升细胞耗氧率（OCR=69%）并促进细胞呼吸。SHO1122147 具备口服活性，适用于肥胖和代谢功能障碍相关脂肪性肝炎 (MASH) 的研究。

BO 1165 is an monobactam antibiotic.

Ro 11-3696 is a bio-active chemical.

RO 116 1148 is a bioactive chemical.

Ro 11-6893 is an active bio-active chemical.

RO116-4875 608 is bioactive chemical.