o 11

O-11 is an analog of the fully saturated, 14-carbon fatty acid myristic acid, in which the methylene group at position 11 is replaced with oxygen. It is highly effective and selective at killingTrypanosoma brucei, the protozoan parasite responsible for African sleeping sickness, exhibiting an LD50of less than 1 μM in a cell culture assay.1,2The toxic effects of O-11 appear to be caused by its ability to inhibit the incorporation of a single myristate into the GPI anchor of the variant surface glycoprotein (VSG), a protein critical for evading the host immune response.1O-11 exhibits essentially no anti-fungal activity when assayed usingC. neoformans, but does have a minor inhibitory effect on HIV-1 replication in T-lymphocytes.3 1.Doering, T.L., Raper, J., Buxbaum, L.U., et al.An analog of myristic acid with selective toxicity for African trypanosomesScience2521851-1854(1991) 2.Doering, T.L., Lu, T., Werbovetz, K.A., et al.Toxicity of myristic acid analogs toward African trypanosomesProceedings of the National Academy of Sciences of the United States of America919735-9739(1994) 3.Langner, C.A., Lodge, J.K., Travis, S.J., et al.4-Oxatetradecanoic acid is fungicidal for Cryptococcus neoformans and inhibits replication of human immunodeficiency virus IThe Journal of Biological Chemisty267(24)17159-17169(1992)

11-O-Galloylbergenin 是从 Mallotus philippinensis 中分离出来的，具有抗氧化和抗疟原虫活性。

11-O-Methylpseurotin A为一种(PKS NRPS)混合聚酮合成酶-非核糖体肽合成酶化合物，其特性为选择性抑制Hof1缺失菌株。

11-O-β-D-glucopyranosyl thamnosmonin是一种香豆素苷，能够从Angelica apaensis根部提取。该化合物对PAF、AA和ADP诱发的兔血小板聚集表现出轻度的抑制效果。

11-O-Syringylbergenin为自龙骨草全草中分离出的岩白菜素类衍生物。

11-Oxomogroside III is a natural product from Siraitia grosvenorii Swingle.

11-Oxomogroside IIIE is a natural product

11-Oxomogroside IV, a natural product, is a triterpenoid glycoside found in the fruit of Siraitia grosvenorii (Monk fruit). It exhibits significant biochemical properties and is often studied for its potential health benefits and applications in sweetening due to its low-caloric content. [1-(a-L-Arabinopyranosyl)-2-[b-D-glucopyranosyl-(1->2)-b-D-glucopyranosyl)-oxomogroside].

3-O-Acetyl-11-hydroxy-beta-boswellic acid 是 5-脂氧合酶抑制剂。

11-O-Mogroside IIIA1 是一种天然产物，可用作天然产物对照品，用于生命科学相关领域的研究，其产品编号为 TN8824。

LysoPalloT-NH-amide-C3-ph-m-O-C11 是一种GPR174激动剂，其EC50为34 nM。

[Sar9,Met(O2)11]-Substance P TFA 是一种选择性的速激肽NK1受体激动剂。

Thalidomide-5-O-C11-NH2 hydrochloride是一款基于Thalidomide的cereblon配体，能够招募CRBN蛋白。该化合物通过linker与靶向蛋白配体结合，用于构建PROTAC分子，如THAL-SNS-032。

Thalidomide-4-O-C11-NH2 hydrochloride是Thalidomide衍生的cereblon配体，能够募集CRBN蛋白。该化合物能够利用linker与目标蛋白配体结合，进而形成PROTAC分子，如THAL-SNS-032。

11α-O-Tigloyl-12β-O-acetyltenacigenin B 是Tenacigenin B 的酯类衍生物，源自藤黄藤 (MTC)。该化合物具有调节Aurora-A活性，对淋巴瘤显示出潜在的抗肿瘤效果。

11,12-Di-O-acetyltenacigenin B 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2577，CAS号为 857897-01-9。

11,12-Di-O-methylcarnosol (Comp 7) 是一种诺利烷二萜内酯，可从迷迭香 (Rosmarinus officinalis L.) 的叶子中分离出来。

11α-O-Benzoyl-12β-O-acetyltenacigenin B，作为Marsdenia tenacissima提取的一种P-糖蛋白(Pgp)抑制剂，属于Tenacigenin B的衍生物。在HepG2 Dox细胞中，它能够抑制由P-糖蛋白(Pgp)过表达引起的多药耐药性(MDR)，展现出在癌症治疗研究中的潜力。

11α-O-Actety-12β-O-tigloyl Tenacissoside A, 一种来自Marsdenia tenacissima的多氧孕烷苷，显示出抗肿瘤活性。

[Sar9,Met(O2)11]-Substance P TFA is a selective tachykinin NK1 receptor agonist.[Sar9,Met(O2)11]-Substance P and septide (10-100 pmol per rat, i.c.v.) are equipotent in increasing mean arterial blood pressure (MAP) and heart rate (HR), yet they have dissi

BO 1165 is an monobactam antibiotic.

Ro 11-3696 is a bio-active chemical.

RO 116 1148 is a bioactive chemical.

Ro 11-6893 is an active bio-active chemical.