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IL-6 Protein, Mouse, Recombinant

产品编号 TMPY-03238

别名: 白介素, Il-6, 白细胞介素, interleukin 6

IL-6 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21.9 kDa and the accession number is P08505.

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IL-6 Protein, Mouse, Recombinant

规格	价格/CNY		货期	数量
20 μg	￥ 1,550		现货
100 μg	￥ 3,930		5日内发货
200 μg	￥ 6,940		5日内发货
500 μg	￥ 14,680		5日内发货

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参考文献

生物活性	Measured in a cell proliferation assay using T1165 mouse plasmacytoma cells. The ED50 for this effect is typically 0.1-0.8 ng/mL.
产品描述	IL-6 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21.9 kDa and the accession number is P08505.

种属	Mouse
表达系统	E. coli
标签	Tag Free
蛋白编号	P08505
别名	白介素, Il-6, 白细胞介素, interleukin 6
蛋白构建	The Mouse IL6 (P08505) (Phe25-Thr211) was expressed and purified.
蛋白纯度	> 90 % as determined by SDS-PAGE
分子量	21.9 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing 50 mM HAc, pH3. 0.Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as a phosphorylated and variably glycosylated molecule. It exerts actions through its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined as an essential role in directing the transition from innate to acquired immunity.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

参考文献

1. Heinrich PC. et al. (2003). Principles of interleukin-6-type cytokine signalling and its regulation. Biochem J. 374: 1-20. 2. Rose-John S, et al. (2007) The IL-6/sIL-6R complex as a novel target for therapeutic approaches. Expert Opin Ther Targets. 11(5): 613-24. 3. Dinh W, et al. (2009) Elevated plasma levels of TNF-alpha and interleukin-6 in patients with diastolic dysfunction and glucose metabolism disorders. Cardiovasc Diabetol. 8:58.

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Keywords

IL-6 Protein, Mouse, Recombinant 白介素 Il-6 白细胞介素 interleukin 6 recombinant recombinant-proteins proteins protein

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