senile

Rosiridin (6'-O-Deacetylrosiridoside C) 能够抑制 MAO A 和 MAO B，有潜在的抑郁症和老年性痴呆作用。它在 10 μM 时对 MAO B 的抑制率为 83.8% (pIC50=5.38)。

Fipexide 是对氯苯乙酸衍生物，是哌嗪化学类的精神活性药物，作为促智药物，有用于老年痴呆的研究潜力。它可降低了纹状体腺苷酸环化酶的活性，通过多巴胺能神经传递对认知表现出积极的作用。

Nicergoline (Nicergolinum) 是一种有效的，选择性的、具有口服活性的α1A-肾上腺素能受体拮抗剂，是一种溴烟碱酸的麦角林衍生物。它具有血管舒张作用，可以改善阿尔茨海默症小鼠的认知功能。

TDN345 is a antagonist of Ca2+, for the treatment of vascular and senile dementia including Alzheimer's disease.

(9R)-RO7185876 (Compound example 16) 是一种γ-secretase抑制剂，能够抑制Αβ42的分泌。此化合物可应用于阿尔茨海默病、脑淀粉样变性血管病、遗传性脑出血伴淀粉样变性、多梗塞性痴呆、老年性痴呆或唐氏综合征的研究。

Amyloid-β (1-42) (Aβ42) is a neurotoxic 42-amino acid protein fragment found in amyloid plaques in postmortem cerebral cortex from patients with Alzheimer's disease.1,2,3Aggregation of Aβ42 results in the formation of neurotoxic fibrils or globular oligomers.1Aβ42 accumulates in the brain of many transgenic mouse models of Alzheimer's disease and, in many models, the onset of amyloid deposition positively correlates with deficits in spatial learning and memory.4 1.Wolfe, M.S.Therapeutic strategies for Alzheimer's diseaseNat. Rev. Drug Discov.1(11)859-866(2002) 2.Iwatsubo, T., Odaka, A., Suzuki, N., et al.Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)Neuron13(1)45-53(1994) 3.Hardy, J.A., and Higgins, G.A.Alzheimer's disease: The amyloid cascade hypothesisScience256(5054)184-185(1992) 4.Jankowsky, J.L., and Zheng, H.Practical considerations for choosing a mouse model of Alzheimer's diseaseMol. Neurodegener.12(1)89(2017)

The amyloid β-protein is a 39- to 43-amino acid polypeptide that is the primary constituent of senile plaques and cerebrovascular deposits in Alzheimer's disease and Down's syndrome. Additionally it acts as an inhibitor of the ubiquitin-dependent protein degradation in vitro.

Timtraxanib (AVI-3207) is a potent and specific inhibitor of VEGF-2, offering great potential for investigating senile macular degeneration.

MHY-1685是一种哺乳动物雷帕霉素靶蛋白(mTOR)抑制剂及衰老抑制剂，通过调节自噬作用能够使衰老的hCSCs恢复活力。

β-Amyloid (12-28) (TFA)为β-淀粉样蛋白(β1-42)的肽片段，后者是由42个氨基酸组成，构成老年斑核心的关键蛋白。β-Amyloid (12-28) (TFA)展现出聚集性质，并可能对阿尔茨海默氏病研究具有潜在价值。

MCI-225 is a norepinephrine reuptake 5-HT3 5-HT reuptake inhibitor. MCI-225 could be effective in the treatment of senile dementia of the Alzheimer type, which is accompanied with both deficit in the BF-cortex cholinergic neuron and cerebral glucose hypom

BMP agonist 2 是一种骨诱导细胞因子，促进骨组织的生成，可用于研究老年性骨质疏松症 (SOP)。BMP agonist 2 具有上调骨形态发生蛋白 BMP-2 在体内表达活性和抗骨质疏松症的作用，还具有改善 SAMP6 小鼠骨质疏松症症状的作用。

HDAC6-IN-37（compound W5）是HDAC6的抑制剂，具有神经保护作用。HDAC6-IN-37可恢复海马神经元形态，减少AD大鼠海马中Aβ、Tau、p-Tau蛋白的表达，抑制老年斑和神经原纤维缠结的形成。因此，HDAC6-IN-37能够改善Aβ Cu2+诱导的AD大鼠模型，调节氧化应激状态，并平衡脑组织中的神经递质紊乱。

Nicergoline-13C-d3 是 Nicergoline 的 13C 和氘代化合物。Nicergoline 的 CAS 号为 27848-84-6。Nicergoline 是一种有效的，选择性的、具有口服活性的α1A-肾上腺素能受体拮抗剂，是一种溴烟碱酸的麦角林衍生物。它具有血管舒张作用，可以改善阿尔茨海默症小鼠的认知功能。

β-amyloid (12-28) TFA, a peptide fragment of β-amyloid protein (β1-42), is the major component of senile plaque cores. β-amyloid (12-28) has aggregation properties and the potential for Alzheimer's disease research.