modulators

CL097 是 TLR7 和 TLR8 的有效激动剂。 CL097 诱导巨噬细胞中的促炎细胞因子和 NADPH 氧化酶引发，从而增加 fMLF 刺激的 ROS 产生。

gamma-Secretase Modulators serves as a useful treatment for Alzheimer's disease by inhibiting the production of Amyloid-β. Specifically, it acts as a gamma-Secretase Modulators with an IC50 value.

NLRP3 modulators 1 (WO2017184746A1, compound 107) is a potent modulator of NLRP3, capable of agonizing or partially agonizing the activity of NLRP3. This compound proves valuable in investigating conditions, diseases, or disorders where a reduction in LRP3 activity plays a role in the pathology.

Lasofoxifene Tartrate (CP-336156) 是一种非甾体类的雌激素受体选择性调节剂 (SERM)。

AMPA receptor modulator-2 是 AMPA 受体的有效调节剂，在 TARPγ2 依赖性 AMPA 受体上的pIC50为 10.1。

1-Methyl-1H-pyrazol-3-amine 是一种吡唑类化合物。它已被用于合成各种化合物，如药物、染料和聚合物。它也是合成某些药物的重要中间体。它还被用于新药的开发，以及酶抑制剂和受体调节剂的研究。

GLP-26 是一种HBV 衣壳组装调节剂，抑制 Hep AD38 系统中的 HBV DNA 复制，IC50值为3 nM。 在 1 μM 时，使 cccDNA 降低> 90％。它破坏前基因组 RNA 的衣壳化，导致核衣壳解体，并减少 cccDNA 库。

NRMA-9 是小分子核受体调节剂的酰胺前体药物。该化合物在脑内具有较高的暴露量，显示出优良的血脑屏障（BBB）穿透能力。NRMA-9 可用于研究与核受体相关的中枢神经系统疾病，如阿尔茨海默和帕金森。

VU0455691 is a selective M1 Muscarinic Receptor Allosteric Modulators.

AZD4800 is a gamma secretase modulators.

GW5638 is a estrogen receptor ligand. GW5638 is a prodrug of its active metabolite GW7604. GW5638 appears to act as an antagonist in these in vitro systems, although in a manner distinct from other known ER modulators. GW5638 is also classified as a pseud

GSK1331258 is a selective, orally bioavailable positive modulators of mGluR2.

GSK1331268 is a selective, orally bioavailable positive modulators of mGluR2.

GSK9772 is a transrepression-selective liver X receptor modulators with anti-inflammatory activity.

LSN2463359是 mGlu5受体的正变构调节剂。

VU0080241 is a positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4).

VU0240382 is a selective positive allosteric modulators of metabotropic glutamate receptor subtype 5.

VU0359516 is a mGluR4 positive allosteric modulators.

VU0361747 is a positive allosteric modulators (PAM) of metabotropic glutamate receptor subtype 5 (mGlu5).

VU0463841 is a mGlu5 negative allosteric modulators.

Kuromanin chloride (Chrysontemin chloride) 是从桑叶中获得，能够提高血糖浓度、维持脂质代谢平衡，表现出降低肥胖的作用。

Spiro-oxanthromicin A is a polyketide that has been found inStreptomyces.1It induces mislocalization of K-RAS in MDCK cells (IC50= 26.7 μM). 1.Salim, A.A., Xiao, X., Cho, K.J., et al.Rare Streptomyces sp. polyketides as modulators of K-Ras localisationOrg. Biomol. Chem.12(27)4872-4878(2014)

Spergualin trihydrochloride is a natural product that first identified as an antibiotic from culture filtrates of Bacillus laterosporus BMG162-aF2[1]. Spergualin trihydrochloride derivatives likely acts as Hsp70 modulators[1]. [1]. Srikanth Patury, et al. Pharmacological Targeting of the Hsp70 Chaperone. Curr Top Med Chem. 2009;9(15):1337-51.

KUS121 is a valosin-containing protein (VCP) modulator that inhibits VCP ATPase activity (IC50= 330 nM).1It inhibits cell death, ATP depletion, and upregulation of C/EBP-homologous protein (CHOP) induced by tunicamycin, an inducer of ER stress, in HeLa cells when used at concentrations of 20, 50, and 50 μM, respectively. KUS121 (100 μM) inhibits ATP depletion and cell death induced by oxygen-glucose deprivation (OGD) in rat primary cortical neurons in anin vitromodel of cerebral ischemia.2It reduces infarction volume and increases the latency to fall in an accelerating rotarod test in a mouse model of focal cerebral ischemia induced by transient distal middle cerebral artery occlusion (MCAO) when administered at a dose of 100 mg/kg immediately following occlusion and again at 50 mg/kg following reperfusion. KUS121 (50 mg/kg) inhibits thinning of the retinal outer nuclear layer and preserves visual function in an rd10 mouse model of retinitis pigmentosa.1 1.Ikeda, H.O., Sasaoka, N., Koike, M., et al.Novel VCP modulators mitigate major pathologies of rd10, a mouse model of retinitis pigmentosaSci. Rep.45970(2014) 2.Kinoshita, H., Maki, T., Yasuda, K., et al.KUS121, a valosin-containing protein modulator, attenuates ischemic stroke via preventing ATP depletionSci. Rep.9(1)11519(2019)