Olezarsen sodium, an N-acetyl-galactosamine-conjugated antisense oligonucleotide, targets hepatic APOC3 mRNA to suppress the production of apolipoprotein C-III (apoC-III). This action helps reduce triglyceride levels in patients at high risk for or with established cardiovascular disease.
Decamethylene glycol is a substance used as a reagent in the biological study of modified oligonucleotide with in vivo antitumoral activity. Also used in the pharmaceutical study on the composition of essential oils obtained from myrrh and frankincense an
5’-O-DMT-PAC-dA can be used in the synthesis of oligoribonucleotides[1]. [1]. Schulhof JC, et, al. The final deprotection step in oligonucleotide synthesis is reduced to a mild and rapid ammonia treatment by using labile base-protecting groups. Nucleic Acids Res. 1987 Jan 26;15(2):397-416.