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Tauroursodeoxycholate sodium

Tauroursodeoxycholate sodium

产品编号 T6993   CAS 35807-85-3
别名: 牛磺熊脱氧胆酸钠, TUDC, Sodium tauroursodeoxycholate, Tauroursodeoxycholic acid sodium salt, Sodium Tauroursodeoxycholate (TUDC), 牛磺熊去氧胆酸钠

Tauroursodeoxycholate sodium 是一种内质网应激抑制剂。Tauroursodeoxycholate 抑制ERK,显著降低凋亡分子表达,如caspase-3和caspase-12。

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Tauroursodeoxycholate sodium, CAS 35807-85-3
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其他形式的 Tauroursodeoxycholate sodium:
产品目录号及名称: Tauroursodeoxycholate sodium (T6993)
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纯度: 99.78%
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生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Tauroursodeoxycholate Sodium is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.
体内活性 In phalloidin-induced cholestasis rats, Tauroursodeoxycholate (360 μmol/kg, i.v.) significantly suppresses the decrease in bile flow and increases in serum alkaline phosphatase, leucine aminopeptidase and glutamic pyruvic transaminase activities, cholesterol, phospholipid and bile acid concentrations. [2]
细胞实验 Cell lines: Mz-ChA-1 cells. Concentrations: ~200 μM. Method: After trypsinization,Mz-ChA-1 cells are suspended in CCM at 5×104 cells/mL,and 200 μL of the cell suspension is seeded into 96-well plates.After an initial incubation step of 4 h at 37°C in a 5% CO2 incubator,the cells are incubated at 37°C with TUDCA (0.2–200 μM).After incubation for 24–96 h,[3H]thymidine is put into each well at 5.0 μCi/mL and incubated for additional 4 h.[3H]thymidine incorporation is measured by a scintillation counter.
动物实验 Animal Models: Phalloidin-induced cholestasis ratsFormulation & . Dosages: Saline; 360 μMol/kg. Administration: intravenous injection
别名 牛磺熊脱氧胆酸钠, TUDC, Sodium tauroursodeoxycholate, Tauroursodeoxycholic acid sodium salt, Sodium Tauroursodeoxycholate (TUDC), 牛磺熊去氧胆酸钠
分子量 521.69
分子式 C26H44NNaO6S
CAS No. 35807-85-3

存储

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

溶解度

Ethanol: 10 mg/mL(19.2 mM)

DMSO: 93 mg/mL (178.3 mM)

H2O: 92 mg/mL (176.3 mM)

( < 1 mg/mL refers to the product slightly soluble or insoluble )

参考文献

1. Milkiewicz P, et al. J Hepatol. 2001, 34(2), 184-191. 2. Ishizaki K, et al. Eur J Pharmacol. 2001, 421(1), 55-60. 3. Alpini G, et al. Am J Physiol Gastrointest Liver Physiol. 2004, 286(6), G973-982. 4. Sommerfeld A, et al. Cell Physiol Biochem. 2015, 36(3), 866-883. 5. Luo R, Li L, Liu X, et al. Mesenchymal stem cells alleviate palmitic acid-induced endothelial-to-mesenchymal transition by suppressing endoplasmic reticulum stress[J]. American Journal of Physiology-Endocrinology and Metabolism. 2020, 319(6): E961-E980. 6. Luo R, Li L, Liu X, et al. Mesenchymal stem cells alleviate palmitic acid induced endothelial to mesenchymal transition by suppressing endoplasmic reticulum stress[J]. American Journal of Physiology-Endocrinology and Metabolism. 2020 7. Che J, Lv H, Yang J, et al. Iron overload induces apoptosis of osteoblast cells via eliciting ER stress-mediated mitochondrial dysfunction and p-eIF2α/ATF4/CHOP pathway in vitro[J]. Cellular Signalling. 2021: 110024.

文献引用

1. Che J, Lv H, Yang J, et al. Iron overload induces apoptosis of osteoblast cells via eliciting ER stress-mediated mitochondrial dysfunction and p-eIF2α/ATF4/CHOP pathway in vitro. Cellular Signalling. 2021 Aug;84:110024. doi: 10.1016/j.cellsig.2021.110024. Epub 2021 Apr 24. 2. Luo R, Li L, Liu X, et al. Mesenchymal stem cells alleviate palmitic acid induced endothelial to mesenchymal transition by suppressing endoplasmic reticulum stress. American Journal of Physiology-Endocrinology and Metabolism. 2020
NM-3 ZNL 02-096 JHU395 PI3K/Akt/mTOR-IN-2 CP 461 AK301 SFI003 (-)-Anonaine

相关化合物库

该产品包含在如下化合物库中:
抗肥胖化合物库 临床期小分子药物库 内质网应激化合物库 谷氨酰胺代谢化合物库 细胞焦亡化合物库 细胞凋亡化合物库 抗胰腺癌化合物库 抑制剂库 抗肝癌化合物库 药物功能重定位化合物库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% ddH2O
计算 重置

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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X
X
=
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g/mol

输入分子式,点击计算,可计算出产品的分子量。

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技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Tauroursodeoxycholate sodium 35807-85-3 Apoptosis MAPK Proteases/Proteasome ERK Caspase molecules UR-906 UR 906 Extracellular signal regulated kinases reticulum caspase-3 牛磺熊脱氧胆酸钠 TUDC Inhibitor endoplasmic Tauroursodeoxycholic acid Sodium tauroursodeoxycholate TUDCA stress Tauroursodeoxycholic acid sodium salt UR906 Sodium Tauroursodeoxycholate (TUDC) 牛磺熊去氧胆酸钠 caspase-12 inhibit Tauroursodeoxycholate inhibitor

 

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