Powder: -20°C for 3 years | In solvent: -80°C for 2 years
Tauroursodeoxycholate sodium 是一种内质网应激抑制剂。Tauroursodeoxycholate 抑制ERK,显著降低凋亡分子表达,如caspase-3和caspase-12。
产品描述 | Tauroursodeoxycholate Sodium is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis. |
体内活性 | In phalloidin-induced cholestasis rats, Tauroursodeoxycholate (360 μmol/kg, i.v.) significantly suppresses the decrease in bile flow and increases in serum alkaline phosphatase, leucine aminopeptidase and glutamic pyruvic transaminase activities, cholesterol, phospholipid and bile acid concentrations. [2] |
细胞实验 | Cell lines: Mz-ChA-1 cells. Concentrations: ~200 μM. Method: After trypsinization,Mz-ChA-1 cells are suspended in CCM at 5×104 cells/mL,and 200 μL of the cell suspension is seeded into 96-well plates.After an initial incubation step of 4 h at 37°C in a 5% CO2 incubator,the cells are incubated at 37°C with TUDCA (0.2–200 μM).After incubation for 24–96 h,[3H]thymidine is put into each well at 5.0 μCi/mL and incubated for additional 4 h.[3H]thymidine incorporation is measured by a scintillation counter. |
动物实验 | Animal Models: Phalloidin-induced cholestasis ratsFormulation & . Dosages: Saline; 360 μMol/kg. Administration: intravenous injection |
别名 | 牛磺熊脱氧胆酸钠, TUDC, Sodium tauroursodeoxycholate, Tauroursodeoxycholic acid sodium salt, Sodium Tauroursodeoxycholate (TUDC), 牛磺熊去氧胆酸钠 |
分子量 | 521.69 |
分子式 | C26H44NNaO6S |
CAS No. | 35807-85-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
Ethanol: 10 mg/mL(19.2 mM)
DMSO: 93 mg/mL (178.3 mM)
H2O: 92 mg/mL (176.3 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
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您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Tauroursodeoxycholate sodium 35807-85-3 Apoptosis MAPK Proteases/Proteasome ERK Caspase molecules UR-906 UR 906 Extracellular signal regulated kinases reticulum caspase-3 牛磺熊脱氧胆酸钠 TUDC Inhibitor endoplasmic Tauroursodeoxycholic acid Sodium tauroursodeoxycholate TUDCA stress Tauroursodeoxycholic acid sodium salt UR906 Sodium Tauroursodeoxycholate (TUDC) 牛磺熊去氧胆酸钠 caspase-12 inhibit Tauroursodeoxycholate inhibitor