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3',4'-Dimethoxyflavone

Name: 3',4'-Dimethoxyflavone
Brand: TargetMol
SKU: TN2883
Price: 129 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.05%

货号 TN2883Cas号 4143-62-8

3',4'-Dimethoxyflavone 是类黄酮化合物的参考标准，类黄酮化合物具有多种药用活性。

3',4'-Dimethoxyflavone

一键复制产品信息

很棒

纯度: 98.05%

货号 TN2883Cas号 4143-62-8

3',4'-Dimethoxyflavone 是类黄酮化合物的参考标准，类黄酮化合物具有多种药用活性。

规格	价格	库存
25 mg	¥ 129	现货
50 mg	¥ 189	现货
1 mL x 10 mM (in DMSO)	¥ 278	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 98.05%

颜色: 白色

性状: Solid

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资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

3',4'-Dimethoxyflavone AI Summary

3',4'-Dimethoxyflavone demonstrates a diverse range of bioactivities affecting multiple biological pathways and cellular processes. It notably exhibits bioactivity against Staphylococcus aureus, inhibiting its growth with a minimum inhibitory concentration (MIC) of 6.3 ug/mL in combination with subinhibitory levels of Berberine. Additionally, it shows antihistaminic activity in rat RBL2H3 cells, with an IC50 value greater than 500,000 nM for the inhibition of DNP-BSA-induced beta-hexosaminidase release. The compound also demonstrates significant bioactivity in various assays, including inhibition of enzymes and proteins such as HSD17B4, JMJD2E, Fructose-1,6-bisphosphate Aldolase, and several others associated with different pathways. It modulates activities like Enhancers of SMN2 Splice Variant Expression, Cytochrome P450 3A4 activation, and USP1/UAF1 inhibition. In AML-2/D100 cells, it shows drug resistance against vincristine with an IC50 of 1200.0 nM. Moreover, 3',4'-Dimethoxyflavone possesses antioxidant activity in rat liver microsomes (IC50 = 40.0 ug/mL), inhibits the growth of human MOLT4, MCF7, and HepG2 cells at 100 uM (though with less than 50% growth inhibition), and inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells. Cytotoxic effects are observed against mouse RAW264.7 cells (IC50 = 39680.0 nM), along with anti-inflammatory activity, inhibiting NO and PGE2 production with IC50 values of 34540.0 nM and 6460.0 nM, respectively. It also inhibits NO production by 33.31% in LPS-stimulated RAW264.7 cells and shows inhibition of CYP450 in human liver microsomes, affecting the formation of 20-HETE and EpETrE with a selectivity index of 0.08 at 10 uM concentration..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	3',4'-Dimethoxyflavone is a reference standard for flavonoid compounds, which have a variety of medicinal activities.

化学信息

分子量	282.29
分子式	C₁₇H₁₄O₄
CAS No.	4143-62-8
Smiles	COc1ccc(cc1OC)-c1cc(=O)c2ccccc2o1
密度	1.242 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (194.84 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.08 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5425 mL	17.7123 mL	35.4246 mL	177.1228 mL
5 mM	0.7085 mL	3.5425 mL	7.0849 mL	35.4246 mL
10 mM	0.3542 mL	1.7712 mL	3.5425 mL	17.7123 mL
20 mM	0.1771 mL	0.8856 mL	1.7712 mL	8.8561 mL
50 mM	0.0708 mL	0.3542 mL	0.7085 mL	3.5425 mL
100 mM	0.0354 mL	0.1771 mL	0.3542 mL	1.7712 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Reactive Oxygen Species poly ADP ribose polymerase PARP neurotrophic neuroprotective Inhibitor inhibit hypolipidaemic human hematopoietic stem cells breast cancer Aryl Hydrocarbon Receptor antioxidant anti-inflammatory anti-cancer anti-atherogenic AhR 3',4'-Dimethoxyflavone 3',4'Dimethoxyflavone 3',4' Dimethoxyflavone

3',4'-Dimethoxyflavone

3',4'-Dimethoxyflavone