Atorvastatin acetonide tert-butyl ester, a valuable pharmaceutical intermediate, is used in preparing Atorvastatin salts, an HMG-CoA reductase inhibitor.
4-(tert-Butyl)-benzhydroxamic Acid is a PqsR antagonist with IC50s of 12.5 μM and 23.6 μM for E. coli and P. aeruginosa, respectively, and it reduces the production of the virulence factor pyocyanin in P. aeruginosa with an IC50 of 87.2 μM[1].
Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine, a cleavable PEG ADC linker, is employed in the synthesis of antibody-drug conjugates (ADCs). It is also a PEG-based PROTAC linker, specifically Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane, widely used in the synthesis of PROTACs[1].
DOTA tert-butyl ester is a phenyl derivative of cycloteramide; it can be directly nitrated; it is more convenient to add nitro after deprotection of lithium aluminum hydride.