ds-2

Positive allosteric modulator of δ-subunit containing GABAA receptors

DS-2969是一种化合物，具有抗菌活性。

DS-2248 is a potent Hsp90 inhbitor, currently in phase I trials.

DS-22-inf-021 是一种对流感病毒具有抗病毒活性的神经氨酸酶 (NA) 抑制剂。

DS21360717 is an effective oral tyrosine kinase inhibitor with anticancer activity and IC50 of 0.49 nM.

DS28120313 is an oral inhibitor of hepcidin production (IC50: 0.093 μM).

Phosphorodithioic acid, S-(2-butylthioethyl) O,O-diethyl ester is a bioactive chemical.

DS20362725是一种选择性的雌激素相关受体α（ERRα）激动剂，能够结合ERRα并增强其转录活性，同时阻止ERRα与其抑制因子，受体相互作用蛋白140（RIP140），结合，常用于研究代谢紊乱疾病。

SB1-F-21 is an UCHL1 inhibitor.

KDS2010 is a potent, highly selective, and reversible MAO-B inhibitor which shows 12,500-fold selectivity over MAO-A. KDS2010 overcomes the disadvantages of the irreversible MAO-B inhibitor and significantly attenuates increased astrocytic GABA levels and astrogliosis, thereby enhancing synaptic transmission, and rescuing learning and memory impairments in APP PS1 mice.

Tisolagiline(KDS2010)是一种强效、高选择性和可逆的MAO-B抑制剂，IC50=8 nM且具有口服活性，可用于治疗阿尔茨海默病和肥胖症。

Datopotamab deruxtecan (DS-1062) 是一种滋养层细胞表面抗原 2 (TROP2) 靶向抗体药物偶联物 （ADC），具有抗肿瘤活性。Datopotamab deruxtecan 在外周血淋巴细胞存在下诱导显着的抗体依赖性细胞毒性，可在异种移植模型中抑制肿瘤生长。

Valemetostat tosylate is a dual inhibitor of EZH1 2 and used in the research of relapsed refractory peripheral T-cell lymphoma.

Valemetostat (DS-3201) 是一种EZH1 2抑制剂，可用于研究复发 难治性周围 T 细胞淋巴瘤。

Milademetan is a potent and selective MDM2 inhibitor. MDM2 inhibitor DS-3032b binds to and prevents the binding of MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53 upon oral administration. By preventing this MDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored. This results in the restoration of p53 signaling and leads to the p53-mediated induction of tumor cell apoptosis.

DS-7423 是PI3K 和mTOR 的有效抑制剂，抑制PI3Kα 和 mTOR 的IC50分别为15.6 nM 和 34.9 nM。DS-7423表现出抗癌活性。

Milademetan (DS-3032) tosylate hydrate，一种特异性、具口服活性的MDM2抑制剂，主要研究用途包括急性髓系白血病和实体肿瘤。它能诱导G1细胞周期阻滞、衰老和凋亡。

Lepunafusp alfa (JR-171) 是一款由 J-Brain Cargo 和 IDUA (α-L-艾杜糖苷酶，溶酶体酶) 构成的血脑屏障透过性融合蛋白。该融合蛋白能有效降低硫酸乙酰肝素 (HS) 与硫酸皮肤素 (DS) 浓度，适合作为 I 型粘多糖贮积症研究用途。

This peptide is a scrambled sequence of NADPH oxidase assembly peptide inhibitor gp91 ds-tat. It is used as a control peptide. It is two amino acid residues shorter at the N-terminus compared to the scrambled gp91 ds-tat.