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顶部生物活性储存和溶解信息计算器

Anti-FADS2 Polyclonal Antibody

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货号 TMAB-00651

别名 Fatty acid desaturase 2, FADS2, Delta(6) fatty acid desaturase (D6D;Delta(6) desaturase;Delta-6 desaturase), Acyl-CoA 6-desaturase

Anti-FADS2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 FADS2。Anti-FADS2 Polyclonal Antibody 可用于 WB。

Anti-FADS2 Polyclonal Antibody

Anti-FADS2 Polyclonal Antibody

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货号 TMAB-00651 别名 Fatty acid desaturase 2, FADS2, Delta(6) fatty acid desaturase (D6D;Delta(6) desaturase;Delta-6 desaturase), Acyl-CoA 6-desaturase

Anti-FADS2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 FADS2。Anti-FADS2 Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-FADS2 Polyclonal Antibody is a Rabbit antibody targeting FADS2. Anti-FADS2 Polyclonal Antibody can be used in WB.
别名Fatty acid desaturase 2, FADS2, Delta(6) fatty acid desaturase (D6D;Delta(6) desaturase;Delta-6 desaturase), Acyl-CoA 6-desaturase
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Chicken,Pig,Cow,Horse,Rabbit)
验证活性
Sample:
Lane 1: Mouse Cerebrum tissue lysates
Lane 2: Mouse Heart tissue lysates
Primary: Anti-FADS2 (TMAB-00651) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 52 kDa
Observed band size: 47 kDa
verifiedActivity
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Endoplasmic reticulum membrane; Multi-pass membrane protein.
组织特异性Expressed in a wide array of tissues, highest expression is found in liver followed by brain, lung, heart, and retina. A lower level is found in breast tumor when compared with normal tissues; lowest levels were found in patients with poor prognostic inde
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1 mg/mL
研究背景Members of the fatty acid desaturase (FADS) family, including FADS1, FADS2 and FADS3, regulate the desaturation of fatty acids by introducing double bonds between defined carbons of fatty acyl chains, thereby playing an essential role in the lipid metabolic pathway. Members of this family share N-terminal cytochrome b5-like domains, C-terminal multiple membrane-spanning desaturase regions and 3 histidine box motifs. FADS2 (fatty acid desaturase 2), also known as D6D, DES6, LLCDL2 or TU13, is a 444 amino acid multi-pass membrane protein that localizes to the endoplasmic reticulum and contains one cytochrome b5 heme-binding domain. Expressed in adult and fetal heart and in adult liver, brain, lung and retina, FADS2 functions as a component of a lipid metabolic pathway and catalyzes the first step in the pathway, namely the formation of unsaturated fatty acids from polyunsaturated fatty acids. Defects in the gene encoding FADS2 are the cause of cause of fatty acid delta-6-desaturase deficiency, an affliction that is characterized by skin abnormalities, corneal ulceration and growth failure. Multiple isoforms of FADS2 exist due to alternative splicing events.
抗原信息
免疫原
KLH conjugated synthetic peptide: human FADS2
抗原种属
Human
基因名称
FADS2
基因ID
9415
蛋白名称
Acyl-CoA 6-desaturase
Uniprot ID
O95864
研究领域
Metabolism,Fatty acids,Fatty acid oxidation,Metabolism,Lipid metabolism
功能
FADS2 (Fatty acid desaturase 2) catalyses the biosynthesis of highly unsaturated fatty acids from precursor essential polyunsaturated fatty acids (linoleic and alpha-linoleic acid). FADS family members comprise an N-terminal cytochrome b5-like domain and a C-terminal membrane-spanning desaturase. FADS2 is repressed by dietary highly unsaturated fatty acids. Altered expression of FADS2 may be associated with obesity-associated insulin resistance. Genetic studies have linked FADS2 to IQ and attention-deficit/hyperactivity disorder (ADHD).
化学信息
分子量Theoretical: 52 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

δ-6 desaturaseδ6 desaturaseδ(6) fatty acid desaturase (D6D;δ(6) desaturase;δ-6 desaturase)FADS 2Delta-6 desaturaseDelta6 desaturased-6 desaturased6 desaturased(6) fatty acid desaturase (D6D;d(6) desaturase;d-6 desaturase)

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