h3n2

Laninamivir octanoate (CS-8958) 是一种长效流感神经氨酸酶抑制剂，是Laninamivir 的前药， 具有优异的抗流感病毒活性。

Ketotifen fumarate (HC 20511 fumarate) 是组胺 H1 受体和炎症介质释放的环七噻吩阻滞剂。

3M-011, a potent dual toll-like receptor TLR7 8 agonist and cytokine inducer, serves as a powerful adjuvant to radiotherapy, eliciting significant local and systemic immune responses. Additionally, it effectively inhibits H3N2 influenza viral replication in the nasal cavity and exhibits strong antitumor activity[1][2][3].

Oseltamivir phosphate (GS 4104) 是一种神经氨酸酶 (NA) 抑制剂，具有口服活性。Oseltamivir phosphate 具有抗病毒活性，对多种流感病毒有效，可以抑制成熟的流感病毒脱离宿主细胞。

Dendrobine 是从石斛中分离的一种生物碱，对甲型流感病毒具有抗病毒活性。

Influenza A virus-IN-1, a dihydropyrrolidones derivative, is a highly effective inhibitor of various subtypes of influenza A virus (IAV) with IC 50 values ranging from 3.11 μM to 7.13 μM. It effectively suppresses IAV replication and enhances the expression of key antiviral cytokines, such as IFN-β, and the antiviral protein MxA.

DPQ is an antiviral compound. DPQ has also been shown to bind to a widened RNA major groove at the internal loop. DPQ acts against the H1N1 and H3N2 strains of influenza A as well as influenza B.

ATV03 是一种高效的抗流感化合物，对甲型及乙型流感病毒均具显著活性。该化合物能够抑制甲型 (H3N2) 和乙型流感病毒，其 EC50 值分别达到 0.78 nM 和 2.02 nM。ATV03 的抗病毒机制主要通过抑制聚合酶酸性蛋白 (PA) 与 RNA 依赖性 RNA 聚合酶 (RdRp) 并破坏核蛋白来实现。

Neuraminidase-IN-23 (33c) 是一种高效的流感病毒神经氨酸酶neuraminidase (NA)抑制剂，其对各类流感病毒的IC50值分别为0.049 μM (H1N1)、0.26 μM (H3N2)、0.17 μM (H5N1)、0.013 μM (H5N8) 和 0.74 μM (H5N1-H274Y)。

ATV2301 是一种口服有效的抗流感药物，其对 H1N1 的 EC50 为 1.88 nM，对 H3N2 的 EC50 为 4.77 nM。ATV2301 的抗流感活性源于其对聚合酶酸蛋白 (PA)、核蛋白 (NP) 以及 RNA 依赖性 RNA 聚合酶 (RdRp) 的影响。

Methyl brevifolincarboxylate (Brevifolincarboxylic acid methyl ester) is a potent influenza virus PB2 cap-binding inhibitor. Methyl brevifolincarboxylate exhibits inhibitory activity against influenza virus A Puerto Rico 8 34 (H1N1) and A Aichi 2 68 (H3N2) with IC50s of 27.16 μM and 33.41 μM. Anti-oxidant activity[1][2]. Methyl brevifolincarboxylate exhibits significant DPPH radical scavenging activity with an IC50 value of 8.9 μM. [1]. Wu QY, et al. Chromatographic fingerprint and the simultaneous determination of five bioactive components of geranium carolinianum L. water extract by high performance liquid chromatography. Int J Mol Sci. 2011;12(12):8740-8749. [2]. Fang SH, et al. Anti-oxidant and inflammatory mediator's growth inhibitory effects of compounds isolated from Phyllanthus urinaria. J Ethnopharmacol. 2008;116(2):333-340.

Pyrindolol is a bacterial metabolite that has been found inS. alboverticillatus.1It inhibits neutral β-galactosidase by 50% under acidic, but not neutral, conditions when used at a concentration of 2 μg ml. It is selective for β-galactosidase isolated from bovine liver over β-galactosidases isolated from human, bovine, pig, and rat tissues and sialidases isolated fromC. perfringens,Streptomyces, and the H3N2 strain of influenza virus (IC50s = >250 μg ml for all).1,2 1.Aoyagi, T., Kumagai, M., Hazato, T., et al.Pyridindolol, a new β-galactosidase inhibitor produced by actinomycetesJ. Antibiot. (Tokyo)28(7)555-557(1975) 2.Kumagai, M., Aoyagi, T., and Umezawa, H.Inhibitory activity of pyridindolol on β-galactosidaseJ. Antibiot. (Tokyo)29(7)696-703(1976)

Aureonitol is a fungal metabolite that has been found inChaetomiumand has antiviral activity.1It inhibits replication of the influenza A subtype H3N2 with an EC50value of 30 nM at a multiplicity of infection (MOI) of 0.01. It also inhibits replication of laboratory-adapted and clinical isolates of H3N2 (EC50s = 100 and 312 nM, respectively), as well as clinical isolates of the influenza A subtype H1N1 (EC50= 417 nM). Aureonitol inhibits hemagglutination activity of H3N2 and H1N1. 1.Sacramento, C.Q., Marttorelli, A., Fintelman-Rodrigues, N., et al.Aureonitol, a fungi-derived tetrahydrofuran, inhibits influenza replication by targeting its surface glycoprotein hemagglutininPLoS One10(10)e0139236(2015)

Oseltamivir (GS 4104) 是一种具有口服活性和高效性的病毒神经氨酸酶 （NA），具有抗病毒活性，抑制 A H3N2，A H1N2，A H1N1 和 B 型流感病毒，可用于研究流感和肺炎。

Anti-Influenza agent 3 (compound 11h) 是有效的抗流感药物，对 MDCK 上皮细胞显示出低细胞毒性。Anti-Influenza agent 3 抑制 M2 WT 和 S31N 离子通道的传导性。Anti-Influenza agent 3 对 A HK 68 (H3N2, M2-WT) 菌株的 EC50值为 3.29 μM，对 A WSN 33 (H1N1, M2-S31N) 菌株的 EC50值为 2.45 μM。

HSP90-IN-14 (compound 4) 是有效的Hsp90 抑制剂（Kd= 0.26μM）。在MDCK 细胞中，HSP90-IN-14 表现出抗流感病毒活性，抗 A H3N2、A H1N1 和 B 型流感病毒的EC50分别为 2.6、3.9 和 17 μM。

Influenza virus-IN-5 (Compound 5f) 是一种流感病毒血球凝集素 (hemagglutinin (HA)) 抑制剂，能够作用于 A H3N2 病毒 (EC50: 1 nM)。

RSV IAV-IN-3 (compound 14'i) 是一种双重的呼吸道合胞病毒 (RSV) (EC50: 2.92 μM) 和甲型流感病毒 (IAV) (EC50: 1.90 μM) 的双重抑制剂。RSV IAV-IN-3 对 H1N1 和 H3N2 表现出抗病毒作用，在 MDCK 细胞中的 EC50值分别为 3.25 μM 和 1.50 μM。RSV IAV-IN-3 能够剂量依赖性地明显抑制荧光素酶的活性 (EC50: 3.89 μM)。RSV IAV-IN-3 可以抑制 IAV 感染和 RdRp 活性，在进入后阶段抑制 IAV 和 RSV 复制。

Cap-dependent endonuclease-IN-17 是帽依赖性核酸内切酶 (CEN) 抑制剂。Cap-dependent endonuclease-IN-17 对流感病毒 A Hanfang 359 95 (H3N2) 表现出抗病毒作用 (IC50: 1.29 μM)。

LUN15104 is a novel hemagglutinin (HA) protein inhibitor, inhibiting entry and replication of diverse influenza viruses via the HA protein, showing potent antiviral activity against diverse H1N1, H5N1, and H3N2 influenza viruses encoding HA proteins from both groups 1 and 2. This product has no formal name. For the convenience of scientific communication, we named it by combining its InChi Key (3 letters from the first letter of each section) with the last 5 digit of its CAS#) according to MedKoo Chemical Nomenclature (https: www.medkoo.com page naming).

BCX-1898 是一种环戊烷衍生物，是口服有效的，选择性的流感病毒神经氨酸酶 (influenza virus neuraminidase) 抑制剂。BCX-1898 具有抗病毒活性，对 MDCK 细胞中的甲型流感病毒 (H1N1、H3N2、H5N1) 和乙型流感病毒复制的 EC50值为 <0.01-21 μM。BCX-1898 显示出对小鼠流感模型的保护作用。

Neuraminidase-IN-16 (Compound 43b) 是一种有效的神经氨酸酶 (neuraminidase) 抑制剂，对 H5N1、H5N8、H1N1、H3N2、H5N1–H274Y 和 H1N1–H274Y 的神经氨酸酶抑制作用的 IC50分别为 0.031、0.15、0.25、0.60、0.63 和 10.08 μM。

CR-8020是一种人源IgG1抗体，专门结合甲型流感病毒H3N2。该抗体与H3N2毒株的血凝素 (HA) 结合，对于A Brisbane 10 2007和A Wyoming 3 2003，其IC50分别为3.36 nM和0.06 nM。CR-8020的同型对照可参考HumanIgG1kappa, Isotype Control。

Oseltamivir-d3 是 Oseltamivir 的氘代化合物。Oseltamivir 的 CAS 号为 196618-13-0。Oseltamivir (GS 4104) 是一种具有口服活性和高效性的病毒神经氨酸酶 （NA），具有抗病毒活性，抑制 A H3N2，A H1N2，A H1N1 和 B 型流感病毒，可用于研究流感和肺炎。