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pNNP

Name: pNNP
Brand: TargetMol
SKU: T34093
Price: 119 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: p-NNP, p-Nitrophenyl phosphate, p NNP, Nitrophenylphosphate

货号 T34093Cas号 330-13-2 一键复制产品信息纯度: 99.82%

很棒

pNNP (Nitrophenylphosphate) 可用作 PP2C 试验的底物。pNNP 对β-碳酸酐酶和α-碳酸酯脱水酶有抑制作用，对幽门螺杆菌幽门螺杆菌也具有抑制作用。pNNP 是一种活性较弱的组织非特异性碱性磷酸酶调节剂。

pNNP

一键复制产品信息

很棒

纯度: 99.82%

货号 T34093Cas号 330-13-2

别名 p-NNP, p-Nitrophenyl phosphate, p NNP, Nitrophenylphosphate

规格	价格	库存
1 mg	¥ 119	现货
5 mg	¥ 247	现货
10 mg	¥ 347	现货
25 mg	¥ 562	现货
50 mg	¥ 828	现货
100 mg	¥ 1,230	现货
500 mg	¥ 3,120	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.82%

颜色: 白色

性状: Solid

资源下载: COA LCMS HNMR产品操作手册

产品介绍

pNNP AI Summary

pNNP exhibits multiple bioactivities across different enzymes and biological targets. It demonstrates inhibitory activity against human serum paraoxonase (PON1) with an IC50 value of 18,500,000 nM and against the Src protein tyrosine kinase SH2 domain with an IC50 value of 1,000,000 nM. Additionally, pNNP acts as an inhibitor of CD45 protein tyrosine phosphatase, with kinetic parameters including a k cat of 3.95 s^-1, a Km of 278,000 nM, and a kcat/Km ratio of 0.000142 M^-1 s^-1. For carbonic anhydrase enzymes, pNNP shows varying catalytic efficiencies. It exhibits a high kcat/Km ratio for mouse carbonic anhydrase 13, indicating strong catalytic efficiency, whereas for human carbonic anhydrase 1 and 2, it demonstrates moderate and lower ratios, respectively. It also inhibits esterase activities of these enzymes as measured by the CO2 hydration method. Moreover, pNNP has inhibitory effects on several phosphatases, including Yersinia pestis PTPase (Km of 600,000 nM), and human STEP (Km of 745,000 nM). It also shows inhibitory activity against PtpB (Km of 1,336,000 nM) and DLODP in human HepG2 microsomal membranes, with an IC50 value of 4,200,000 nM. In terms of drug metabolism, pNNP is metabolized in mouse liver homogenates with significant hydrolysis at different pH levels, showing higher metabolism rates at pH 5 compared to pH 9.6. This indicates efficient liver metabolism under acidic conditions..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	pNNP (Nitrophenylphosphate) can be used as a substrate for the PP2C assay. pNNP inhibits β-carbonic anhydrase and α-carbonate dehydrogenase, as well as H. pylori Helicobacter pylori. pNNP is a weakly active, tissue-nonspecific alkaline phosphatase modifier. pNNP has been shown to inhibit β-carbonic anhydrase and α-carbonate dehydrogenase.
别名	p-NNP, p-Nitrophenyl phosphate, p NNP, Nitrophenylphosphate

化学信息

分子量	219.09
分子式	C₆H₆NO₆P
CAS No.	330-13-2
Smiles	O(P(=O)(O)O)C1=CC=C(N(=O)=O)C=C1
密度	1.712 g/cm3 (Predicted)

储存&溶解度

存储

Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 60 mg/mL (273.86 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.5643 mL	22.8217 mL	45.6433 mL	228.2167 mL
5 mM	0.9129 mL	4.5643 mL	9.1287 mL	45.6433 mL
10 mM	0.4564 mL	2.2822 mL	4.5643 mL	22.8217 mL
20 mM	0.2282 mL	1.1411 mL	2.2822 mL	11.4108 mL
50 mM	0.0913 mL	0.4564 mL	0.9129 mL	4.5643 mL
100 mM	0.0456 mL	0.2282 mL	0.4564 mL	2.2822 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。