thiazide-like

Clopamide (Brinaldix) 是口服有效的噻嗪类利尿剂，对钠耦合的氯离子共转运蛋白 SLC12A3有抑制作用。Clopamide 在高血压和心力衰竭中具有研究价值。

Meticrane (Arresten) 是一种磺胺类衍生物，具有类似噻嗪类利尿剂的活性，可于研究原发性高血压。

Chlorthalidone 是噻嗪类利尿剂，有用于高血压的研究潜力。

Pyrazinoylguanidine (PZG) 是与保钾利尿剂Amiloride相似的化合物。它能够降低原发性高血压患者的收缩压和舒张压，并有一定程度的心率降低效果，同时不影响血清中钠、钾、氯等电解质的浓度。此外，Pyrazinoylguanidine 可以减轻2型糖尿病患者的高血糖和高胰岛素血症，降低甘油三酯、胆固醇及游离脂肪酸水平，并能逆转因噻嗪类利尿剂（如Hydrochlorothiazide）引起的高血糖和高血脂。它还能抑制肾小管对尿素的重吸收，提高尿素的清除率和排泄量，降低血清尿素浓度，减少毒性蓄积。

Fenquizone (M.G. 13054) 是一种噻嗪样利尿剂，具有慢性抗高血压作用。Fenquizone 可用于水肿和高血压的研究。

Chlorthalidone impurity G is a potential impurity found in commercial preparations of chlorthalidone that has moderate antihypertensive effects. Chlorthalidone is a thiazide-like diuretic that inhibits the Na+/Cl- cotransporter in the distal convoluted tubule of the kidney, which prevents reabsorption of sodium and chloride leading to a reduction in plasma volume and cardiac output. It also inhibits carbonic anhydrase (CA), including the isoforms CAVB, VII, IX, XII, and XIII (Kis = 2.8-23 nM) and, to a lesser extent, CAI, CAII, IV, VA, and VI (Kis = 138-1,347 nM), which may mediate its sustained vasodilatory activity. Dietary administration of chlorthalidone (8 mg per animal per day) reduces arterial hypertension and prevents or reduces ventricular hypertrophy induced by deoxycorticosterone acetate (DOCA) in salt-hypertensive rats. Formulations containing chlorthalidone have been used alone or in combination with other antihypertensive agents to lower arterial blood pressure and as adjuvants to address edema caused by cardiac or renal disorders.

Chlorthalidoneimpurity，作为Chlorthalidone的代谢物，该物质属于噻嗪类利尿剂，主要用于高血压的研究。

Chlorthalidone-D4是Chlorthalidone (T1091)的氘代化合物。Chlorthalidone的CAS号为77-36-1。Chlorthalidone是噻嗪类利尿剂，有用于高血压的研究潜力。

Clopamide (Standard) 是 Clopamide 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Clopamide (Brinaldix) 是口服有效的噻嗪类利尿剂，对钠耦合的氯离子共转运蛋白 SLC12A3有抑制作用。Clopamide 在高血压和心力衰竭中具有研究价值。