abacavir

Abacavir (Ziagen) 是一种核苷类似物逆转录酶抑制剂。

Abacavir sulfate (Ziagen) 是一种核苷类似物逆转录酶抑制剂，可用于 HIV 和 AIDS。

Abacavir hydroxyacetate 是一个具有口服活性的核苷类似物逆转录酶抑制剂.具有抗 HIV 和免疫调节活性，在小鼠模型中诱导动脉血栓形成，可用于研究 HIV 感染。

Abacavir carboxylate is an inactive metabolite of the HIV-1 reverse transcriptase inhibitor abacavir . It is formed from abacavir via reactive aldehyde intermediates that can form adducts with proteins on valine residues.

Abacavir monosulfate is an orally active, competitive nucleoside reverse transcriptase inhibitor that effectively inhibits HIV replication. Additionally, it exhibits anticancer properties in prostate cancer cell lines, and has the ability to penetrate the blood-brain-barrier and suppress telomerase activity [1] [2] [3].

ent-Abacavir is an enatiomer of Abacavir. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection. Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA. Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.

Abacavir-d4 是 Abacavir 的氘代化合物。Abacavir 的 CAS 号为 136470-78-5。Abacavir是一种核苷类似物逆转录酶抑制剂。

9-((1R,4S)-4-(tert-Butoxymethyl)cyclopent-2-en-1-yl)-N6-cyclopropyl-9H-purine-2,6-diamine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64644。

Scopadulciol is and enzyme and proton pump inhibitor.

Apricitabine (SPD754) 是一种具有高选择性和口服活性的HIV-1逆转录酶抑制剂(Ki=0.08μM)，是2′-脱氧-3′-氧-4′-硫代胞苷(dOTC)的(-)对映体 。 Apricitabine 对DNA 聚合酶α、β和γ具有抑制作用，Ki 值分别为300μM、12μM 和112.25μM。Apricitabine 在抗逆转录病毒HIV 感染者中显示出良好的抗逆转录病毒治疗效果，具有良好的耐受性和较低的选择性抗性。

2-Amino-6-cyclopropylamino-9H-purine 是阿巴卡韦(abacavir) 的关键中间体，以氰基乙酸乙酯为原料，经亚硝化、盐酸胍在 EtONa 存在下环合、还原得到2,4,5-三氨基-6-羟基嘧啶

(+)-Carbovir triphosphate is an active metabolite of Abacavir. It was used to study the molecular mechanism of inhibition and drug resistance for HIV-1 reverse transcriptase.