nucleotide excision repair

ERCC1-XPF-IN-2 在核苷酸切除修复、顺铂增强和 γH2AX 测定中具有活性。ERCC1-XPF-IN-2 是 ERCC1-XPF 核酸内切酶的有效抑制剂，IC50值为 0.6 μM。

Nemorubicin HCL is the salt form of Nemorubicin, also known as PNU152243A, a doxorubicin derivative that differs significantly from its parent drug in terms of spectrum of antitumor activity, metabolism and toxicity profile. The drug is active on tumors resistant to alkylating agents, topoisomerase II inhibitors and platinum derivatives. It works primarily through topoisomerase I inhibition. Of note, Nemorubicin is active in cells with upregulation of the nucleotide excision repair (NER) pathway, where current therapies fail. Nemorubicin is biotransformed in the liver into cytotoxic metabolites that may further contribute to render this drug highly active against primary liver tumors or liver metastases.

NTPO trisodium 是一种 DNA 损伤诱导剂，会导致基因组 DNA 损伤和断裂，并激活 ATR 介导的细胞周期检查点。NTPO trisodium 导致的 DNA 损伤效果可以通过碱基切除修复（BER）而非核苷酸切除修复（NER）来消除。