Neprilysin

Neprilysin, also known as membrane metallo-endopeptidase (MME), neutral endopeptidase (NEP), cluster of differentiation 10 (CD10), and common acute lymphoblastic leukemia antigen (CALLA) is an enzyme that in humans is encoded by the MME gene. Neprilysin is a zinc-dependent metalloprotease that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. It also degrades the amyloid beta peptide whose abnormal folding and aggregation in neural tissue has been implicated as a cause of Alzheimer's disease. Synthesized as a membrane-bound protein, the neprilysin ectodomain is released into the extracellular domain after it has been transported from the Golgi apparatus to the cell surface.

Cat. No.	Product Name	CAS No.	Purity
T2318	Sacubitril/Valsartan 沙库必曲/缬沙坦	936623-90-4	99.94%
T2318	LCZ696 是由 Valsartan (an ARB) 和 Sacubitril (AHU377) 组成，摩尔比为 1:1，是一种首创的，口服有效的血管紧张素受体-脑啡肽酶 (ARN) 双抑制剂，用于研究高血压和心力衰竭。它可通过抑制炎症、氧化应激和细胞凋亡来改善糖尿性心肌病。
T7693	Thiorphan 3-巯基-2苄基丙基甘氨酸	76721-89-6	99.91%
T7693	Thiorphan 是选择性neprilysin抑制剂 (IC50:6.9 nM) 。
T4200	Sacubitril hemicalcium salt LCZ696中间体	1369773-39-6	99.28%
T4200	Sacubitril hemicalcium salt 是一种有效的NEP抑制剂，IC50=5 nM。它是研究心力衰竭药物 LCZ696 的组分之一。
TQ0106	Sacubitrilat 化合物Sacubitrilat	149709-44-4	99.11%
TQ0106	Sacubitrilat 是活性的脑啡肽酶 (NEP) 抑制剂。
T1176	Racecadotril 消旋卡多曲	81110-73-8	98.86%
T1176	Racecadotril 是一种中性内肽酶 (NEP) 抑制剂，具有止泻作用。Racecadotril 及其活性代谢物 Thiorphan 抑制小鼠脑中纯化的NEP活性，Ki分别为 4500 和 6.1 nM。
T4574	Sacubitril 沙库必曲	149709-62-6	98.28%
T4574	Sacubitril 是一种有效的NEP抑制剂，IC50=5 nM。它是研究心力衰竭药物 LCZ696 的组分之一。
T19626	LHW090-A7 化合物LHW090-A7	1308256-94-1	98.26%
T19626	LHW090-A7 是一种中性肽链内切酶 (NEP) 抑制剂，是一种负责脑啡肽代谢失活的酶。
T6627	Phosphoramidon Disodium 磷酰胺二钠	164204-38-0	98%
T6627	Phosphoramidon Disodium Salt 是一种金属蛋白酶 (metalloprotease) 抑制剂。Phosphoramidon Disodium Salt抑制内皮素转化酶 (ECE) ，中性肽内切酶 (NEP) 和血管紧张素转换酶 (ACE) 的IC50分别为 3.5 ，0.034 和 78 μM...
T10918	NEP-IN-1 化合物NEP-In-1	465527-94-0	98%
T10918	NEP-IN-1 是中性肽链内切酶 (NEP) 的抑制剂 (IC50 = 2 nM)。