FABP

The fatty-acid-binding proteins (FABPs) are a family of transport proteins for fatty acids and other lipophilic substances such as eicosanoids and retinoids. These proteins are thought to facilitate the transfer of fatty acids between extra- and intracellular membranes. Some family members are also believed to transport lipophilic molecules from outer cell membrane to certain intracellular receptors such as PPAR. The FABPs are intracellular carriers that “solubilize” the endocannabinoid anandamide (AEA), transporting AEA to the breakdown by FAAH, and compounds that bind to FABPs block AEA breakdown, raising its level. The cannabinoids (THC and CBD) are also discovered to bind human FABPs (1, 3, 5, and 7) that function as intracellular carriers, as THC and CBD inhibit the cellular uptake and catabolism of AEA by targeting FABPs. Competition for FABPs may in part or wholly explain the increased circulating levels of endocannabinoids reported after consumption of cannabinoids. Levels of fatty-acid-binding protein have been shown to decline with ageing in the mouse brain, possibly contributing to age-associated decline in synaptic activity.

Cat. No.	Product Name	CAS No.	Purity
T4534	BMS-309403 化合物BMS-309403	300657-03-8	99.54%
BMS309403 是有效的、选择性脂肪细胞脂肪酸结合蛋白aFABP抑制剂。它可改善载脂蛋白E缺乏症小鼠和培养的人内皮细胞的内皮功能。它能够与蛋白质内部的脂肪酸结合口袋相互作用，竞争性地抑制内源性脂肪酸的结合。
T11257	FABP-IN-1 化合物 T11257	2132990-90-8	98%
FABP-IN-1 inhibits FABP3, FABP5, and FABP7 with Ki values of 0.69 μM, 0.55 μM and 0.67 μM, respectively. FABP-IN-1 displays potent antinociceptive effects. FABP-...
T11258	FABP5-IN-1 化合物 T11258	2132990-98-6	98%
FABP5-IN-1 shows potent antinociceptive effects. FABP5-IN-1 is a selective and high affinity fatty acid binding protein 5 (FABP5) inhibitor with a Ki value of 1....
T12852	SBFI-26 化合物 T12852	1541207-06-0	98%
SBFI-26 is a selective and competitive fatty acid binding proteins FABP5 and FABP7 inhibitor(FABP5 and FABP7 with Kis of 0.9 μM and 0.4 μM, respectively), with a...

Cat. No.

Product Name

CAS No.

Purity

Chemical Structure

T4534

BMS-309403

化合物BMS-309403

300657-03-8

99.54%

BMS309403 是有效的、选择性脂肪细胞脂肪酸结合蛋白aFABP抑制剂。它可改善载脂蛋白E缺乏症小鼠和培养的人内皮细胞的内皮功能。它能够与蛋白质内部的脂肪酸结合口袋相互作用，竞争性地抑制内源性脂肪酸的结合。

T11257

FABP-IN-1

化合物 T11257

2132990-90-8

98%

FABP-IN-1 inhibits FABP3, FABP5, and FABP7 with Ki values of 0.69 μM, 0.55 μM and 0.67 μM, respectively. FABP-IN-1 displays potent antinociceptive effects. FABP-...

T11258

FABP5-IN-1

化合物 T11258

2132990-98-6

98%

FABP5-IN-1 shows potent antinociceptive effects. FABP5-IN-1 is a selective and high affinity fatty acid binding protein 5 (FABP5) inhibitor with a Ki value of 1....

T12852

SBFI-26

化合物 T12852

1541207-06-0

98%

SBFI-26 is a selective and competitive fatty acid binding proteins FABP5 and FABP7 inhibitor(FABP5 and FABP7 with Kis of 0.9 μM and 0.4 μM, respectively), with a...