首页 工具
登录
购物车
FABP

FABP

The fatty-acid-binding proteins (FABPs) are a family of transport proteins for fatty acids and other lipophilic substances such as eicosanoids and retinoids. These proteins are thought to facilitate the transfer of fatty acids between extra- and intracellular membranes. Some family members are also believed to transport lipophilic molecules from outer cell membrane to certain intracellular receptors such as PPAR. The FABPs are intracellular carriers that “solubilize” the endocannabinoid anandamide (AEA), transporting AEA to the breakdown by FAAH, and compounds that bind to FABPs block AEA breakdown, raising its level. The cannabinoids (THC and CBD) are also discovered to bind human FABPs (1, 3, 5, and 7) that function as intracellular carriers, as THC and CBD inhibit the cellular uptake and catabolism of AEA by targeting FABPs. Competition for FABPs may in part or wholly explain the increased circulating levels of endocannabinoids reported after consumption of cannabinoids. Levels of fatty-acid-binding protein have been shown to decline with ageing in the mouse brain, possibly contributing to age-associated decline in synaptic activity.
Cat. No. Product Name CAS No. Purity Chemical Structure
T78960 FABP4-IN-2
化合物 FABP4-IN-2
98%
FABP4-IN-2(Compd 10g)是一种选择性的口服活性FABP4抑制剂,其对FABP4的Ki值为0.51 μM,而对FABP3的Ki值为33.01 μM。该化合物适用于研究与炎症相关的疾病。
T4534 BMS-309403
化合物BMS-309403
300657-03-8 98%
BMS309403 是有效的、选择性脂肪细胞脂肪酸结合蛋白 aFABP 抑制剂。它可改善载脂蛋白 E 缺乏症小鼠和培养的人内皮细胞的内皮功能。它能够与蛋白质内部的脂肪酸结合口袋相互作用,竞争性地抑制内源性脂肪酸的结合。
FABP4-IN-2
T78960
FABP4-IN-2(Compd 10g)是一种选择性的口服活性FABP4抑制剂,其对FABP4的Ki值为0.51 μM,而对FABP3的Ki值为33.01 μM。该化合物适用于研究与炎症相关的疾病。
BMS-309403
T4534
BMS309403 是有效的、选择性脂肪细胞脂肪酸结合蛋白 aFABP 抑制剂。它可改善载脂蛋白 E 缺乏症小鼠和培养的人内皮细胞的内皮功能。它能够与蛋白质内部的脂肪酸结合口袋相互作用,竞争性地抑制内源性脂肪酸的结合。
联系我们
400-820-0310

上海市静安区江场三路238号8楼