首页工具

登录

搜索结果

Search Results for " leptin "

22

抑制剂 & 化合物

17

重组蛋白

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T39418	Leptin (93-105), human
	Leptin (93-105), human, refers to the peptide fragment consisting of amino acids 93 to 105 from the human leptin protein. Leptin is a peptide hormone comprising 167 amino acids, predominantly synthesized by adipocytes. Its primary function involves coordinating metabolic adaptations to fasting within the central nervous system.
TP1356	Leptin (22-56), human
	Leptin(22-56),human is a peptide fragment of Leptin, which ACTS through a variety of subtypes of Ob-Rs.
T76221	Leptin (116-130)
	Leptin(116-130)是一种生物活性的瘦素片段，能促进AMPA受体运输至突触并加强活动依赖性的海马突触可塑性。此外，Leptin(116-130)在抗淀粉样蛋白毒性模型中有效阻止海马突触损伤和神经元细胞死亡，显示出对研究阿尔茨海默病(AD)具有重要潜力。
T7704	KY-226	Phosphatase	Metabolism
	KY-226 是选择性的，口服活性的和变构蛋白酪氨酸磷酸酶 1B 抑制剂，IC50=0.25 μM，且不激活 PPARγ 。它可以保护神经元免受脑缺血损伤。它通过增强胰岛素和瘦素信号传导发挥抗糖尿病和抗肥胖作用。
T2008	LY294002 LY 294002,NSC 697286,SF 1101	Apoptosis; DNA-PK; Casein Kinase; PI3K; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells
	LY294002 (SF 1101) 是一种 PI3K 的广谱抑制剂，抑制 PI3Kα、PI3Kδ 和 PI3Kβ (IC50=0.5/0.57/0.97 μM)。LY294002 也是 DNA-PK 抑制剂 (IC50=1.4 μM) 和 CK2 抑制剂 (IC50=98 nM)。LY294002 可以激活凋亡和自噬。
T4079	LY-294002 hydrochloride SF 1101,LY 294002,NSC 697286	PI3K	PI3K/Akt/mTOR signaling
	LY-294002 hydrochloride (NSC 697286) 是一种合成的 PI3Kα/δ/β 分子抑制剂（IC50：0.5/0.57/0.97 μM，在无细胞试验中）；在溶液中比 Wortmannin 更稳定，也是自噬体形成的阻断剂。
T32645	Leptine I, from Solanum chacoense Leptine I
	Leptine I, from Solanum chacoense is a glycoalkaloid in the foliage of the wild potato species Solanum chacoense.
TP1305	LEP(116-130)(mouse)	Others	Others
	LEP(116-130)(mouse) 是合成的瘦素肽片段之一。
TP1305L	LEP(116-130)(mouse)TFA(258276-95-8 free base)	Complement System	Immunology/Inflammation
	LEP(116-130)(mouse)TFA(258276-95-8 free base) 是一种合成的瘦素肽片段。
T23557	Talibegron hydrochloride ZD2079 hydrochloride,ZD 2079	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Talibegron hydrochloride (ZD2079 hydrochloride) 是一种β3肾上腺素能受体激动剂，对苯肾上腺素预收缩大鼠肠系膜动脉的 pD2为3.72。松弛大鼠肠系膜动脉和离体主动脉。在体内抑制瘦小鼠 ob 基因表达和循环瘦素水平。
T78020	Allo-aca
	Allo-aca是一种高效且特异性的瘦素受体(leptin receptor)拮抗剂肽，能在多种体外和体内模型中阻断瘦素信号传导和作用。
T81628	OB3
	OB3, 相比于Leptin，在降低小鼠模型的肥胖和糖尿病方面显示出更高效。此化合物能够降低肝癌细胞内瘦素相关的炎症及其增殖作用。
T83145	Allo-aca TFA
	Allo-aca TFA是一种有效且特异性的瘦素肽模拟物，具备瘦素受体(leptin receptor)拮抗剂的属性。在多种体外及体内模型中，该化合物能够有效阻断瘦素信号传输及其生物效应。
TP2215	Agouti-related Protein (AGRP) (25-82), human	Others	Others
	Agouti-related peptide (AgRP) is a neuropeptide produced in the brain by the AgRP/NPY neuron. It is only synthesized in NPY containing cell bodies located in the ventromedial part of the arcuate nucleus in the hypothalamus. The appetite-stimulating effect
T75899	CART(55-102)(human) TFA
	CART(55-102)(human) TFA，一种与瘦素和神经肽 Y 密切相关的人源饱腹感因子，具有显著的抑制食欲作用。
T72745	Acipimox sodium K-9321 sodium
	Acipimox (K-9321) sodium 为烟酸类似物，能抗脂及抑制脂肪分解。该化合物通过刺激瘦素释放、抑制脂解作用及全身游离脂肪水平，进而改善胰岛素敏感性。
T75900	CART(55-102)(rat) TFA
	CART(55-102)(rat) TFA，一种鼠源性饱腹感因子，具强烈抑制食欲作用，与瘦素及神经肽 Y 有密切关联，能诱导焦虑及压力相关行为。
T71559	Melanotan II acetate
	Melanotan II acetate is an agonist of melanocortin receptor 1 (MC1R), MC3R, MC4R, and MC5R. It has been shown to improve recovery of sciatic nerve function after mechanical injury and increase cisplatin-induced decreases in sensory nerve conduction velocity. Melanotan II acetate increases oxygen consumption and protein levels of uncoupling protein 1 (UCP1) in brown adipose tissue homogenates and decreases food intake, body weight, and serum levels of leptin, glucose, insulin, and cholesterol.
T76366	CART (55-76), rat
	CART (55-76), rat 为一种神经肽，构成CART (55-102)的N端片段，属于鼠源性饱腹感因子，具有显著的抑食作用，并与瘦素及神经肽Y关系紧密。此外，CART (55-76), rat 还能诱发与焦虑和压力相关的行为。
T36106	Coumermycin A1
	Coumermycin A1 is a JAK2 signal activator. Coumermycin A1 inhibits DNA Gyrase which thereby inhibits cell division in bacteria. Coumermycin A1-induced-JAK2 signal activation increases the mRNA level of SCOS2, but reducea leptin receptor mRNA level[1]. [1]. Tiantian Zhang, et al. SOCS2 Inhibits Mitochondrial Fatty Acid Oxidation via Suppressing LepR/JAK2/AMPK Signaling Pathway in Mouse Adipocytes. Research Article.
T76365	CART (1-39), Human, Rat
	CART (1-39), Human, Rat, 是一种由其1至39个残基构成的神经肽, 具有明显的减少食欲作用, 被认为是鼠类的饱腹因子, 并与瘦素及神经肽Y有着紧密的联系。它能有效抑制正常及饥饿状态下的摄食行为, 同时也能引发焦虑与压力相关的反应。
T83906	Tirzepatide sodium LY3298176
	Tirzepatide 是一种glucagon-like peptide 1 receptor (GLP-1R) 和 G protein-coupled receptor 119 (GPR119)的激动剂。它在表达人类GLP-1R或GPR119的HEK293细胞中诱导cAMP的产生（EC50s分别为6.54和1.01 nM）。Tirzepatide（100 nM）在表达人类GLP-1R或GPR119的HEK293细胞中诱导受体内化。在体内，Tirzepatide（每天10 nmol/kg）降低高脂饮食诱导的肥胖小鼠模型的体重、食物摄入量、血浆leptin、三酸甘油酯和free fatty acids (FFAs)水平、肝脏三酸甘油酯和血糖水平。它通过每三天给药50 nmol/kg的剂量，阻止A. alternata诱导的A. alternata挑战小鼠的支气管肺泡灌洗液（BALF）中嗜酸性粒细胞和淋巴细胞数量的增加。Tirzepatide（每三天50 nmol/kg）抑制由毒蕈碱受体激动剂methacholine (acetyl-β-methylcholine)导致的在糖尿病诱导的哮喘...

化合物

Leptin (93-105), human

Cat.No: T39418

Leptin (22-56), human

Cat.No: TP1356

Leptin (116-130)

Cat.No: T76221

Cat.No: T7704

Target: Phosphatase

Cat.No: T2008

Synonym: LY 294002,NSC 697286,SF 1101

Target: Apoptosis, DNA-PK, Casein Kinase, PI3K, Autophagy

LY-294002 hydrochloride

Cat.No: T4079

Synonym: SF 1101,LY 294002,NSC 697286

Target: PI3K

Leptine I, from Solanum chacoense

Cat.No: T32645

Synonym: Leptine I

LEP(116-130)(mouse)

Cat.No: TP1305

Target: Others

LEP(116-130)(mouse)TFA(258276-95-8 free base)

Cat.No: TP1305L

Target: Complement System

Talibegron hydrochloride

Cat.No: T23557

Synonym: ZD2079 hydrochloride,ZD 2079

Target: Adrenergic Receptor

Cat.No: T78020

Cat.No: T81628

Cat.No: T83145

Agouti-related Protein (AGRP) (25-82), human

Cat.No: TP2215

Target: Others

CART(55-102)(human) TFA

Cat.No: T75899

Acipimox sodium

Cat.No: T72745

Synonym: K-9321 sodium

CART(55-102)(rat) TFA

Cat.No: T75900

Melanotan II acetate

Cat.No: T71559

CART (55-76), rat

Cat.No: T76366

Cat.No: T36106

CART (1-39), Human, Rat

Cat.No: T76365

Tirzepatide sodium

Cat.No: T83906

Synonym: LY3298176

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00875	Leptin Protein, Human, Recombinant OBS,leptin,OB,LEPD	Human	E. coli
	Leptin Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 16 kDa and the accession number is A4D0Y8.
TMPY-01725	Leptin Receptor Protein, Human, Recombinant (His) LEPRD,OB-R,OBR,LEP-R,CD295,leptin receptor	Human	HEK293 Cells
	Leptin Receptor Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 95 kDa and the accession number is P48357-1.
TMPY-06375	Leptin Protein, Mouse, Recombinant (mFc) leptin,ob,obese	Mouse	HEK293 Cells
	Leptin Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 43.33 kDa and the accession number is P41160.
TMPJ-00052	Leptin Protein, Mouse, Recombinant OB,Obesity Factor,OBS,LEP,Obese Protein,Leptin	Mouse	E. coli
	Leptin is a hormone secreted from white adipocytes and plays important role in the regulation of food intake and energy balance. Leptin functions via signaling pathways involving OB-R in hypothalamus. Animal models have revealed the influence of Leptin in reducing body weight and regulating blood glucose level. When mutations are introduced in obese gene, mice with impaired function of leptin are massively obese and in high risk of diabetes. Leptin deficiency reduces metablic rate. Leptin defici...
TMPJ-00606	Leptin Protein, Carassius auratus, Recombinant (His) OB,Leptin,LEP,Obese Protein,OBS,Obesity Factor	Carassius auratus	P. pastoris (Yeast)
	Leptin is a hormone secreted from white adipocytes and plays important role in the regulation of food intake and energy balance. Leptin functions via signaling pathways involving OB-R in hypothalamus. In mammals, leptin is mainly produced by the adipose tissue and encodes body fat reserves, acting as a short-term satiety signal. In fish, the presence of a leptin-like peptide was first evidenced by immuno-cross-reactivity, and its existence was certainly demonstrated after the finding by synteny ...
TMPK-00050	Leptin Protein, Mouse, Recombinant (hFc) LEP,Obesity factor,Leptin,LEPD,Obese protein,OBS,OB	Mouse	HEK293 Cells
	Leptin has key roles in the regulation of energy balance, body weight, metabolism, and endocrine function. Leptin levels are undetectable or very low in patients with lipodystrophy, hypothalamic amenorrhea, and congenital leptin deficiency (CLD) due to mutations in the leptin gene.
TMPY-00874	Leptin Receptor Protein, Human, Recombinant (His & hFc) LEP-R,OBR,CD295,OB-R,LEPRD,leptin receptor	Human	HEK293 Cells
	Leptin Receptor Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 121.4 kDa and the accession number is P48357-1.
TMPJ-00975	LEPR Protein, Mouse, Recombinant (hFc) CD295,DB,HuB219,OB receptor,LEP-R,Leptin receptor,O...	Mouse	HEK293 Cells
	LEPR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 130-190 KDa and the accession number is P48356.
TMPJ-00411	LEPR Protein, Human, Recombinant (hFc) LEPR,Leptin receptor,OB-R,OB receptor,OBR,CD295,DB,...	Human	HEK293 Cells
	LEPR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 150-180 KDa and the accession number is P48357.
TMPJ-00976	LEPR Protein, Mouse, Recombinant (His) OBR,DB,Leptin receptor,OB receptor,CD295,OB-R,LEPR,...	Mouse	HEK293 Cells
	LEPR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-10His tag. The predicted molecular weight is 120-150 KDa and the accession number is P48356.
TMPJ-00977	LEPR Protein, Mouse, Recombinant (mFc) LEPR,CD295,OB-R,LEP-R,HuB219,Leptin receptor,OBR,DB...	Mouse	HEK293 Cells
	LEPR Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 130-190 KDa and the accession number is P48356.
TMPJ-01473	BMP-7 Protein, Human, Recombinant Eptotermin alfa,OP-1,OP1,Osteogenic protein 1,Bone morphogen...	Human	HEK293 Cells
	Bone morphogenetic protein 7 (BMP7), also known as osteogenic protein-1 (OP-1) is a member of Transforming growth factor-β (TGF-β) family of proteins. Bone morphogenetic proteins were discovered in 1965 by Marshal Urist, of which BMP7 is of particular interest in this review being a leptin-independent anorexinogen and having role in energy expenditure in the brown adipose tissue, which makes it a potential target for preventing/treating obesity. As it has been established that Obesity displays a...
TMPJ-01061	Nucleobindin-2 Protein, Human, Recombinant NUCB2,NEFA,Gastric cancer antigen Zg4,Nesfatin-1,Prepronesfa...	Human	E. coli
	Nesfatin-1 is a metabolic polypeptide encoded in the N-terminal region of the precursor protein, Nucleobindin2 (NUCB2). Nesfatin-1 is a neuropeptide produced in the hypothalamus of mammals. It participates in the regulation of hunger and fat storage. Nesfatin-1 is also expressed in other areas of the brain, and in pancreatic islets β-cells, gastric endocrine cells and adipocytes. Nesfatin-1 suppresses food intake and can regulate energy metabolism in a Leptin independent manner. Nesfatin-1 may ...
TMPJ-00286	ANGPTL3 Protein, Human, Recombinant (hFc) ANGPTL3,ANGPT5,Angiopoietin-related protein 3,ANG-5,Angiopoi...	Human	HEK293 Cells
	Angiopoietin-like 3 (ANGPTL3) is a secreted glycoprotein that is structurally related to the angiopoietins. Mature human ANGPTL3 contains an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain. ANGPTL3 is expressed in the liver from early in development through adulthood. Full length ANGPTL3 circulates in the plasma as do the proteolytically separated N-and C-terminal segments containing the coiled coil domain and fibrinogen-like domains,respectively. ANGPTL3 directly inhibits ...
TMPY-00286	Neuropeptide Y Protein, Human, Recombinant (hFc) PYY4,neuropeptide Y	Human	HEK293 Cells
	NPY (Neuropeptide Y) is a Protein Coding gene. This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. NPY is a neuromodulator that is widely expressed throughout the central nervous system (CNS) and is consecrated with classic neurotransmitters including GABA and glutamate. NPY/Agouti-related protein (AgRP) ne...
TMPY-02194	SOCS3 Protein, Human, Recombinant (His & Trx) SOCS-3,SSI-3,ATOD4,Cish3,SSI3,suppressor of cytokine signali...	Human	E. coli
	Suppressor of cytokine signaling 3, also known as SOCS-3, Cytokine-inducible SH2 protein 3, CIS-3, STAT-induced STAT inhibitor 3, SOCS3 and CIS3, is a protein which is widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. SOCS3 / CIS3 contains one SH2 domain and one SOCS box domain. SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. ...
TMPH-02274	JAK2 Protein, Human, Recombinant (His)	Human	E. coli
	Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple int...

重组蛋白

Leptin Protein, Human, Recombinant

Cat.No: TMPY-00875

Species: Human

Expression System: E. coli

Leptin Receptor Protein, Human, Recombinant (His)

Cat.No: TMPY-01725

Species: Human

Expression System: HEK293 Cells

Leptin Protein, Mouse, Recombinant (mFc)

Cat.No: TMPY-06375

Species: Mouse

Expression System: HEK293 Cells

Leptin Protein, Mouse, Recombinant

Cat.No: TMPJ-00052

Species: Mouse

Expression System: E. coli

Leptin Protein, Carassius auratus, Recombinant (His)

Cat.No: TMPJ-00606

Species: Carassius auratus

Expression System: P. pastoris (Yeast)

Leptin Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00050

Species: Mouse

Expression System: HEK293 Cells

Leptin Receptor Protein, Human, Recombinant (His & hFc)

Cat.No: TMPY-00874

Species: Human

Expression System: HEK293 Cells

LEPR Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00975

Species: Mouse

Expression System: HEK293 Cells

LEPR Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00411

Species: Human

Expression System: HEK293 Cells

LEPR Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00976

Species: Mouse

Expression System: HEK293 Cells

LEPR Protein, Mouse, Recombinant (mFc)

Cat.No: TMPJ-00977

Species: Mouse

Expression System: HEK293 Cells

BMP-7 Protein, Human, Recombinant

Cat.No: TMPJ-01473

Species: Human

Expression System: HEK293 Cells

Nucleobindin-2 Protein, Human, Recombinant

Cat.No: TMPJ-01061

Species: Human

Expression System: E. coli

ANGPTL3 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00286

Species: Human

Expression System: HEK293 Cells

Neuropeptide Y Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00286

Species: Human

Expression System: HEK293 Cells

SOCS3 Protein, Human, Recombinant (His & Trx)

Cat.No: TMPY-02194

Species: Human

Expression System: E. coli

JAK2 Protein, Human, Recombinant (His)

Cat.No: TMPH-02274

Species: Human

Expression System: E. coli

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼