LEPR Protein, Mouse, Recombinant (His)

LEPR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-10His tag. The predicted molecular weight is 120-150 KDa and the accession number is P48356.

规格	价格/CNY		数量
10 μg	￥ 820	5日内发货
50 μg	￥ 2,480	5日内发货
500 μg	￥ 12,400	5日内发货
1 mg	￥ 18,700	5日内发货

规格

价格/CNY

货期

数量

10 μg

￥ 820

5日内发货

50 μg

￥ 2,480

5日内发货

500 μg

￥ 12,400

5日内发货

1 mg

￥ 18,700

5日内发货

产品描述	LEPR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-10His tag. The predicted molecular weight is 120-150 KDa and the accession number is P48356.

种属	Mouse
表达系统	HEK293 Cells
标签	C-10xHis
蛋白编号	P48356
别名	OBR, DB, Leptin receptor, OB receptor, CD295, OB-R, LEPR, HuB219, LEP-R
氨基酸序列	Leu22-Gly839
蛋白构建	Leu22-Gly839
蛋白纯度	Greater than 90% as determined by reducing SDS-PAGE. (QC verified)
分子量	120-150 KDa (reducing condition)

内毒素	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	The Leptin receptor is a member of the Class I cytokine receptor family. It mediates the activities of Leptin, a multi-functional hormone produced primarily by adipose tissues that plays roles in food intake, energy metabolism, angiogenesis, reproduction, hematopoiesis, bone metabolism, and immune function. The human Leptin R gene encodes 1165 amino acids (aa) including a signal peptide, an extracellular region with cytokine receptor homology (CRH), multiple fibronectin type III domains and a WSXWS motif, a transmembrane domain, and a cytoplasmic domain that supports JAK/STAT signaling. Soluble Leptin R is the primary Leptin-binding protein in blood, where it maintains a pool of available bioactive Leptin, delays Leptin clearance from circulation, and down-regulates blood-brain transmission of Leptin. In humans, soluble Leptin R levels are inversely proportional to adiposity and are elevated in females versus males. Soluble Leptin R is also found up-regulated in patients with chronic heart failure, end-stage renal disease, and anorexia.It is expressed by tumor-initiating stem cells, and is proposed as a link between cancer and obesity.

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LEPR Protein, Mouse, Recombinant (His)

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