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LEPR Protein, Human, Recombinant (hFc)

LEPR Protein, Human, Recombinant (hFc)

产品编号 TMPJ-00411
别名: LEPR, Leptin receptor, OB-R, OB receptor, OBR, CD295, DB, HuB219, LEP-R

LEPR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 150-180 KDa and the accession number is P48357.

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LEPR Protein, Human, Recombinant (hFc)
规格 价格/CNY 货期 数量
10 μg ¥ 380 5日内发货
50 μg ¥ 1,170 5日内发货
500 μg ¥ 7,110 5日内发货
1 mg ¥ 10,600 5日内发货
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产品目录号及名称: LEPR Protein, Human, Recombinant (hFc) (TMPJ-00411)
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产品描述 LEPR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 150-180 KDa and the accession number is P48357.
种属 Human
表达系统 HEK293 Cells
标签 C-hFc
蛋白编号 P48357
别名 LEPR, Leptin receptor, OB-R, OB receptor, OBR, CD295, DB, HuB219, LEP-R
氨基酸序列 Phe22-Asp839
蛋白构建 Phe22-Asp839
蛋白纯度 Greater than 90% as determined by reducing SDS-PAGE. (QC verified)
分子量 150-180 KDa (reducing condition)
内毒素 < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法 Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 The Leptin receptor is a member of the Class I cytokine receptor family. It mediates the activities of Leptin, a multi-functional hormone produced primarily by adipose tissues that plays roles in food intake, energy metabolism, angiogenesis, reproduction, hematopoiesis, bone metabolism, and immune function. The human Leptin R gene encodes 1165 amino acids (aa) including a signal peptide, an extracellular region with cytokine receptor homology (CRH), multiple fibronectin type III domains and a WSXWS motif, a transmembrane domain, and a cytoplasmic domain that supports JAK/STAT signaling. Soluble Leptin R is the primary Leptin-binding protein in blood, where it maintains a pool of available bioactive Leptin, delays Leptin clearance from circulation, and down-regulates blood-brain transmission of Leptin. In humans, soluble Leptin R levels are inversely proportional to adiposity and are elevated in females versus males. Soluble Leptin R is also found up-regulated in patients with chronic heart failure, end-stage renal disease, and anorexia.It is expressed by tumor-initiating stem cells, and is proposed as a link between cancer and obesity.

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Keywords

LEPR Protein, Human, Recombinant (hFc) LEPR Leptin receptor OB-R OB receptor CD 295 HuB-219 HuB 219 OBR CD295 DB CD-295 HuB219 LEP-R recombinant recombinant-proteins proteins protein

 

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