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Anti-Leptin Receptor Antibody (9N607)
还可以产品编号 TMAY-00607
Anti-Leptin Receptor Antibody (9N607) 是一种 Mouse 抗体，靶向 Leptin Receptor。Anti-Leptin Receptor Antibody (9N607) 可用于 ELISA。
Anti-Leptin Receptor Antibody (9N607)
Anti-Leptin Receptor Antibody (9N607)
还可以产品编号 TMAY-00607
Anti-Leptin Receptor Antibody (9N607) 是一种 Mouse 抗体，靶向 Leptin Receptor。Anti-Leptin Receptor Antibody (9N607) 可用于 ELISA。
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抗原信息
| 产品描述 | Anti-Leptin Receptor Antibody (9N607) is a Mouse antibody targeting Leptin Receptor. Anti-Leptin Receptor Antibody (9N607) can be used in ELISA. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 9N607 |
| 交叉反应 | Human |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:1000-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Leptin Receptor / CD295 / LEPR (rh Leptin Receptor / CD295 / LEPR; TMPY-01725; NP_002294.2; Met 1-Asp 839). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS with 10% Trehalose, pH7.0 |
| 研究背景 | Leptin Receptor or CD295 belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight) and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Leptin Receptor/CD295 is transmembrane catalytic receptors found on NPY/AgRP and alpha-MSH/CART neurons in hypothalamic nuclei. Leptin receptors (Ob-Rs) are coded for by one human gene that produces six different isoforms; Ob-Ra - Ob-Rf. Ob-Rs exist as constitutive dimers at physiological expression levels. Only the Ob-Rb isoform can transduce intracellular signals and does so through activation of the JAK2/STAT3, PI 3-K, and MAPK signaling cascades. Activation of Ob-Rs mediates transcriptional regulation of the hypothalamic melanocortin pathway and downregulates endocannabinoid expression. Leptin acts via leptin receptors. Leptin resistance has been proposed as a pathophysiological mechanism of obesity. In obese individuals, Ob-Ra (which is involved in the active transport of leptin across the blood-brain barrier) expression is downregulated and the individual may be unresponsive to leptin signals. Ob-R antagonists are of great interest in the development of pharmacological treatments for obesity. Mutations in the Leptin Receptor/CD295 have been associated with obesity and pituitary dysfunction. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human Leptin Receptor / CD295 / LEPR protein (TMPY-01725) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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