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顶部产品介绍偶联与修饰抗原信息储存和溶解信息计算器

Anti-Leptin Antibody (5I154)

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货号 TMAY-00487

别名 obese, ob, leptin

Anti-Leptin Antibody (5I154) 是一种 Mouse 抗体，靶向 Leptin。Anti-Leptin Antibody (5I154) 可用于 ELISA(Det)。

Anti-Leptin Antibody (5I154)

Anti-Leptin Antibody (5I154)

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Rating icon 还可以
货号 TMAY-00487 别名 obese, ob, leptin

Anti-Leptin Antibody (5I154) 是一种 Mouse 抗体，靶向 Leptin。Anti-Leptin Antibody (5I154) 可用于 ELISA(Det)。

规格价格库存数量
20 μL
¥ 595
5日内发货
100 μL
¥ 1,684
5日内发货
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产品介绍

生物活性
产品描述
Anti-Leptin Antibody (5I154) is a Mouse antibody targeting Leptin. Anti-Leptin Antibody (5I154) can be used in ELISA(Det).
别名obese, ob, leptin
Ig Type
Mouse IgG2b
克隆号
5I154
反应种属
Human
特异性
Human Leptin
应用ELISA(Det)
抗体种类
Monoclonal
宿主来源Mouse
构建方式This product is a recombinant monoclonal antibody expressed from HEK293 cells.
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景Leptin is one of the most important hormones secreted by adipocytes, as an adipokine that modulates multiple functions including energy homeostasis, thermoregulation, bone metabolism, endocrine, and pro-inflammatory immune responses. The circulating leptin levels serve as a gauge of energy stores, thereby directing the regulation of energy homeostasis, neuroendocrine function, and metabolism. Recent studies suggest that leptin is physiologically more important as an indicator of energy deficiency, rather than energy excess, and may mediate adaptation by driving increased food intake and directing neuroendocrine function to converse energy, such as inducing hypothalamic hypogonadism to prevent fertilization. One of these functions is the connection between nutritional status and immune competence. The adipocyte-derived hormone Leptin has been shown to regulate the immune response, innate, and adaptive response, both in normal and pathological conditions. Thus, Leptin is a mediator of the inflammatory response. Leptin has a dual effect on bone, acting by two independent mechanisms. As a signal molecule with growth factor characteristics, leptin can stimulate osteoblastic cells and inhibit osteoclast formation and activity, thus promoting osteogenesis. However, as a molecule that stimulates sympathetic neurons in the hypothalamus, leptin indirectly inhibits bone formation. This inhibitory effect of leptin mediated by activation of the sympathetic nervous system can be abrogated by the application of blood pressure-reducing beta-blockers, which also inhibit receptors of hypothalamic adrenergic neurons. Leptin appears to regulate some features defining Alzheimer's disease (AD) at the molecular and physiological level. Leptin can stimulate mitogenic and angiogenic processes in peripheral organs. Because leptin levels are elevated in obese individuals and excess body weight has been shown to increase breast cancer risk in postmenopausal women. Furthermore, a recent report clearly shows that targeting leptin signaling may reduce mammary carcinogenesis.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
HRP
可提供抗体种类
2
抗原信息
免疫原
Recombinant Protein: Human Leptin Protein (TMPY-00875)
抗原种属
Human
研究领域
Neurotransmitter Associated Enzymes
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.
存储-20°C for 1 year

计算器

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