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80

抑制剂 & 化合物

22

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T10016	Hydrocarbon chain derivative 1 6,6'-Oxybis[2,2-dimethyl-1-hexanol]	Others	Others
	Hydrocarbon chain derivative 1 has inhibitory activities against lipid synthesis.
T7202	ITE	AhR; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism
	ITE 是一种有效的芳烃受体 (AhR) 内源性激动剂，Ki 值为 3 nM。它具有免疫抑制作用。
T21966	MeBIO	GSK-3; Aryl Hydrocarbon Receptor; CDK	Cell Cycle/Checkpoint; Immunology/Inflammation; PI3K/Akt/mTOR signaling; Stem Cells
	MeBIO 是一种芳烃受体激动剂，对 GSK-3 和 CDK1/CyclinB 的 IC50 分别为 44 和 55 μM。 MeBIO 不影响 GSK-3β。
T1960	YL-109	AhR; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism
	YL-109是一种抗肿瘤剂，可以通过芳烃受体 AhR 信号传导诱导 Hsp70 相互作用蛋白 (CHIP) 表达，具有抑制乳腺癌细胞生长和侵袭性的能力。
T5622	BAY-218 AHR antagonist 1	AhR; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism
	BAY-218 (AHR antagonist 1) 是一种芳基烃受体(AHR)拮抗剂，在人细胞系中的IC50值为 39.9 nM。
T10007	1,4-Chrysenequinone Chrysene-1,4-dione,1,4-屈醌	AhR	Immunology/Inflammation; Metabolism
	1,4-Chrysenequinone (Chrysene-1,4-dione) 是多环芳香烃类，是芳烃受体 (AhR) 的激活剂
T10270	BAY 2416964	Aryl Hydrocarbon Receptor	Immunology/Inflammation
	BAY 2416964 是一种可口服的芳基烃受体拮抗剂，IC50为 341 nM，可用于研究实体瘤。
T4608	PDM2	AhR; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism
	PDM2 是一种有效的选择性芳烃受体 (AhR) 拮抗剂，Ki 为 1.2±0.4 nM。
T15410	GNF351	Aryl Hydrocarbon Receptor	Immunology/Inflammation
	GNF351 是芳烃受体 (AhR) 的完全拮抗剂，具有抑制 DRE 依赖性和非依赖性活性的能力。它与结合到 AhR 的光亲和性 AhR 配体竞争，IC50为 62 nM。它在小鼠或人角质形成细胞中的毒性极小。
T20625	Prochloraz 咪鲜胺,Sporgon,Prelude	Estrogen Receptor/ERR; AhR; Androgen Receptor; Antifungal	Endocrinology/Hormones; Immunology/Inflammation; Metabolism; Microbiology/Virology
	Prochloraz (Prelude) 是咪唑类抗真菌剂。Prochloraz 抑制羊毛甾醇的细胞色素 P450 依赖性 14α-脱甲基作用，由此抑制麦角固醇的生物合成，从而导致真菌细胞膜破裂和细胞死亡。它也是雌激素受体和雄激素受体的拮抗剂，IC50分别为25 μM 和4 μM，并激活芳烃受体，EC50为1μM。
T2448	CH-223191 CH 223191	AhR; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism
	CH-223191 是一种特异性有效的芳烃受体 (AhR) 拮抗剂，可抑制 TCDD 介导的核转位和 AhR 的 DNA 结合，抑制 TCDD 诱导的荧光素酶活性的 IC50值为 0.03 μM。
T4607	CAY 10465 CAY10465,CAY10465 Exclusive	AhR; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism
	CAY 10465 是一种选择性和高亲和力的芳香烃受体(AhR)激动剂，Ki 值为 0.2 nM。
TQ0257	FICZ 6-Formylindolo[3,2-b]carbazole	Aryl Hydrocarbon Receptor	Immunology/Inflammation
	FICZ (6-Formylindolo[3,2-b]carbazole) 是芳烃受体 (AhR) 的有效芳基激动剂，Kd 值为70 pM。
T1831	StemRegenin 1 SR1	AhR; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism
	StemRegenin 1 (SR1) 是一种芳香烃受体拮抗剂，IC50为 127 nM。
T13276	VAF347 4-(3-氯苯基)-N-[4-(三氟甲基)苯基]嘧啶-2-胺	Aryl Hydrocarbon Receptor	Immunology/Inflammation
	VAF347 是细胞可渗透且高度亲和力的芳烃受体激动剂，可诱导AhR 信号传导，具有抗炎作用。它抑制颗粒单核细胞 (GM 期) 前体中 CD14+CD11b+单核细胞的发育。
T21704	5-fluoro 203 5F-203,NSC-703786	Others	Others
	5-fluoro 203 (NSC-703786) 是一种细胞毒性分子。它可激活芳香烃受体(AhR) 信号传导，诱导 CYP1A1 的转录，从而形成 DNA 加合物以及细胞周期阻滞。它可以提高活性氧水平，并激活 ERK、p38以及JNK。
T2148	Carbidopa monohydrate Carbidopa Hydrate,S(-)-Carbidopa,卡比多巴水合物	Decarboxylase; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism; Others
	Carbidopa monohydrate (S(-)-Carbidopa) 是一种外周型脱羧酶抑制剂，可用于帕金森病的研究。它是一种选择性芳香烃受体 (AhR) 调节剂。它抑制胰腺癌细胞和肿瘤生长。
T4644	Tapinarof GSK2894512,Benvitimod,苯烯莫德,WBI 1001	AhR; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism
	Tapinarof (Benvitimod) 是一种从发光杆菌中提取的天然产物，可消除炎症。它是芳烃受体 (AhR) 激动剂，EC50为 13 nM。
T2623	PD98059 PD 98059	ERK; Aryl Hydrocarbon Receptor; MEK; Autophagy	Autophagy; Immunology/Inflammation; MAPK
	PD98059 是一种 MEK 抑制剂，抑制 MEK1 和 MEK2 (IC50=2/50 μM)，具有非 ATP 竞争性。PD98059 也是一种 AHR 的配体而起拮抗作用。PD98059 可以抑制细胞自噬。
T0640	Benzyl butyl phthalate BBP,邻苯二甲酸丁苄酯,1,2-benzenedicarboxylic acid,butyl phenylmethyl ester,Butyl benzyl phthalate	Others; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Others
	Benzyl butyl phthalate (1,2-benzenedicarboxylic acid) 是邻苯二甲酸酯的一员，可激活乳腺癌细胞中的芳香烃受体，刺激 SPHK1/S1P/S1PR3 信号传导，促进转移性乳腺癌干细胞的形成。它通过上调 Zeb1 的表达，可引起血管瘤细胞的迁移和侵袭。
T2707	Pifithrin-α hydrobromide Pifithrin hydrobromide,Pifithrin-α (PFTα) HBr,Pifithrin-α,PFTα,PFTα hydrobromide	Ferroptosis; Aryl Hydrocarbon Receptor; p53	Apoptosis; Immunology/Inflammation
	Pifithrin-α hydrobromide (Pifithrin-α hydrobromide) 是一种 p53 抑制剂，可抑制 p53 反应基因的 p53 依赖性反式激活。它也是芳烃受体的激动剂。
T10269	AHR antagonist 2	Aryl Hydrocarbon Receptor	Immunology/Inflammation
	AHR antagonist 2 是芳基烃受体的拮抗剂。人 AHR 和小鼠 AHR 的 IC50 分别为 0.885 和 2.03 nM。
T8980	SGA360	Aryl Hydrocarbon Receptor	Immunology/Inflammation
	SGA360 是选择性芳烃 (Ah) 受体调节剂。它具有抗炎特性。
T5541	PDM11 1-[2-(4-Chloro-phenyl)-vinyl]-3,5-diMeth,PDM 11	AhR	Immunology/Inflammation; Metabolism
	PDM11 (1-[2-(4-Chloro-phenyl)-vinyl]-3,5-diMeth) 是抗氧化剂白藜芦醇的衍生物。它在白藜芦醇活性测定中不活跃。它对辐射分解产生的羟基自由基引发的亚油酸胶束氧化没有明显的保护作用。
T0352	Dibenzothiophene 二苯并噻吩,Imino semicarbazide,Diphenylene sulfide	Others	Others
	Dibenzothiophene (Imino semicarbazide) 是有机合成过程的中间体，是由两个苯环稠合到一个中心的噻吩环。
T19057	Solvent Blue 35 Sudan Blue II,溶剂蓝35,溶剂蓝 35,Oil Blue 35	Others	Others
	Solvent Blue 35 (Sudan Blue II) 是一种可用于着色醇类和烃基溶剂的染料。它能够作用于染色动物组织中的甘油三酯。
T0954	Halothane Narcotane,氟烷,Anestan	Potassium Channel; Chloride channel; GABA Receptor; NMDAR	Membrane transporter/Ion channel; Neuroscience
	Halothane (Anestan) 可以减弱内皮依赖性舒张作用。
T10325	ANI-7	Chk	Cell Cycle/Checkpoint
	ANI-7是芳香烃受体（AhR）途径的激活剂。ANI-7抑制多种癌症细胞的生长，并有效且选择性地抑制MCF-7乳腺癌症细胞的生长（GI50:0.56μM）。
T34298	Retene NSC 26317,NSC-26317,NSC26317
	Retene (NSC-26317) 广泛存在于近代和古代沉积物中，可从冷杉林土壤、腐殖质煤、陆相石油烃源岩和深海沉积物中提取得到化合物。Retene 是松木酸在成岩作用过程中脱氢产生的。
T3637	Pifithrin-β hydrobromide Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide)	Ferroptosis; p53	Apoptosis
	Pifithrin-β hydrobromide (Cyclic PFT-α) 是一种 p53 的抑制剂，可逆地阻断 p53 依赖性转录激活和细胞凋亡。IC50值为23 μM。
T10526	β-NF-JQ1	Others	Others
	β-NF-JQ1是一种PROTAC，可将芳烃受体E3 （AhR E3）连接酶招募到目标蛋白上。β-NF-JQ1使用β-NF 作为AhR 配体靶向含溴odomain（BRD）的蛋白，诱导AhR 和BRD 蛋白相互作用。β-NF-JQ1显示出与蛋白敲除活性相关的强大的抗癌活性。
T36696	DMBA
	7,12-Dimethylbenz[a]anthracene (DMBA) is a polycyclic aromatic hydrocarbon (PAH) that has been found in tobacco smoke and diesel exhaust and has carcinogenic activity.1,2It undergoes metabolic activation by numerous enzymes, including the cytochrome P450 (CYP450) isoform CYP1B1, as well as microsomal epoxide hydrolase (mEH), producing a variety of reactive metabolites that form DNA adductsin vivo, and it has been commonly used to induce tumor formation in various rodent models.2,3,1DMBA increase...
T20307	Benzyl 2-naphthyl ether AI3 00945,AI300945,AI3-00945
	Benzyl 2-naphthyl ether causes the activation of the aryl hydrocarbon receptor.
T23994	Dibenzo(a,i)pyrene DB(a,i)p,Benzo(rst)pentaphene
	Dibenzo(a, i)pyrene is a polycyclic aromatic hydrocarbon with potent carcinogenic activity.
T24960	10-Cl-BBQ 10ClBBQ
	10-Cl-BBQ is a ligand of aryl hydrocarbon receptor (AhR).
T25235	CHD-5 CHD5
	CHD-5 is a selective antagonist of the aryl hydrocarbon receptor (AhR).
T23686	AHR-activator-1023 Branching Morphogenesis Modulator 1023,Cpd 1023,Compound 1023,BMM 1023
	AHR-activator-1023 is the aryl hydrocarbon receptor activator. It is also a specific FGF2-induced branching morphogenesis modulator.
T16082	Mivotilate YH439	Others	Others
	Mivotilate, a potent, non-toxic aryl hydrocarbon receptor (AhR) activator, functions as a hepatoprotective agent.
T10258	AFP464 free base NSC710464 free base	HIF	Angiogenesis; Chromatin/Epigenetic
	AFP464 (NSC710464) free base is an active HIF-1α inhibitor (IC50: 0.25 μM) and a potent aryl hydrocarbon receptor (AhR) activator.
T14059	6-Maleimidocaproic acid-PFP ester	Others	Others
	6-Maleimidocaproic acid-PFP ester is a hydrocarbon-based PROTAC linker, suitable for the synthesis of PROTACs[1].
T22528	6,2',4'-Trimethoxyflavone	Others	Others
	The compound is an Aryl hydrocarbon receptor antagonist (EC50 = 0.9 μM). It also has no short term agonist activity and no species or promoter dependence.
T10271	AHR antagonist 4	Others	Others
	AHR antagonist 4 is a potent aryl hydrocarbon receptor (AHR) antagonist(example 293; IC50: 82.2 nM).It has anti-cancer effects.
T10272	AHR antagonist 5	Others	Others
	AHR antagonist 5 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist(example 39; IC50 < 0.5 μΜ). It significantly inhibits tumor growth combined with checkpoint inhibitor anti-PD-1.
T19927	Asphalt Bitumen,Asphalt fumes,Dacholeum
	Asphalt is a dark liquid. It is also a mixture of heavy hydrocarbon residues including saturated and unsaturated hydrocarbons and aromatic hydrocarbons.
T10273	AhR modulator-1	Others	Others
	AhR modulator-1 is a selective and orally active aryl hydrocarbon receptor (AhR) modulator. It inhibits metastasis, in part, by inhibiting prostatic VEGF production prior to tumor formation. It also possesses anti-estrogenic properties in rat uterus.
T70240	Caparratriene
	Caparratriene is a new sesquiterpene hydrocarbon isolated from Ocotea caparrapi with potential for significant growth inhibitory activityagainst CEM leukemia cells
T38393	Ipatasertib-NH2 dihydrochloride RG7440-NH2 dihydrochloride,Ipatasertib-NH2 dihydrochloride,GDC-0068-NH2 dihydrochloride
	Ipatasertib-NH2 dihydrochloride is a ligand for the target protein AKT in PROTAC INY-03-041. INY-03-041 consists of Ipatasertib-NH2, a ten-hydrocarbon linker, and the CRBN ligand Lenalidomide, which acts as an E3 ubiquitin ligase.
T20161	Lauroyl alanine Lauroylalanine,N-Lauroyl-L-alanine,Aminiosurfact LA
	Lauroyl alanine is a fatty acid amide. It may be used to support the physical gelation of binary mixtures of aliphatic and aromatic hydrocarbon solvents.
T22725	DiMNF	Others	Others
	DiMNF is a selective aryl hydrocarbon receptor (AHR) modulator. It also suppresses the expression of CD55 and CD46 induced by IL-1β in an inflammatory tumor cell microenvironment.
T23400	StemRegenin 1 (hydrochloride) StemRegenin 1 (hydrochloride) (1227633-49-9 free base)	Others	Others
	StemRegenin 1 is an aryl hydrocarbon receptor signaling antagonist (IC50: 127 nM in CD34+ cells).

化合物

Hydrocarbon chain derivative 1

Cat.No: T10016

Synonym: 6,6'-Oxybis[2,2-dimethyl-1-hexanol]

Target: Others

Cat.No: T7202

Target: AhR, Aryl Hydrocarbon Receptor

Cat.No: T21966

Target: GSK-3, Aryl Hydrocarbon Receptor, CDK

Cat.No: T1960

Target: AhR, Aryl Hydrocarbon Receptor

Cat.No: T5622

Synonym: AHR antagonist 1

Target: AhR, Aryl Hydrocarbon Receptor

1,4-Chrysenequinone

Cat.No: T10007

Synonym: Chrysene-1,4-dione,1,4-屈醌

Target: AhR

Cat.No: T10270

Target: Aryl Hydrocarbon Receptor

Cat.No: T4608

Target: AhR, Aryl Hydrocarbon Receptor

Cat.No: T15410

Target: Aryl Hydrocarbon Receptor

Cat.No: T20625

Synonym: 咪鲜胺,Sporgon,Prelude

Target: Estrogen Receptor/ERR, AhR, Androgen Receptor, Antifungal

Cat.No: T2448

Synonym: CH 223191

Target: AhR, Aryl Hydrocarbon Receptor

Cat.No: T4607

Synonym: CAY10465,CAY10465 Exclusive

Target: AhR, Aryl Hydrocarbon Receptor

Cat.No: TQ0257

Synonym: 6-Formylindolo[3,2-b]carbazole

Target: Aryl Hydrocarbon Receptor

Cat.No: T1831

Synonym: SR1

Target: AhR, Aryl Hydrocarbon Receptor

Cat.No: T13276

Synonym: 4-(3-氯苯基)-N-[4-(三氟甲基)苯基]嘧啶-2-胺

Target: Aryl Hydrocarbon Receptor

Cat.No: T21704

Synonym: 5F-203,NSC-703786

Target: Others

Carbidopa monohydrate

Cat.No: T2148

Synonym: Carbidopa Hydrate,S(-)-Carbidopa,卡比多巴水合物

Target: Decarboxylase, Aryl Hydrocarbon Receptor

Cat.No: T4644

Synonym: GSK2894512,Benvitimod,苯烯莫德,WBI 1001

Target: AhR, Aryl Hydrocarbon Receptor

Cat.No: T2623

Synonym: PD 98059

Target: ERK, Aryl Hydrocarbon Receptor, MEK, Autophagy

Benzyl butyl phthalate

Cat.No: T0640

Synonym: BBP,邻苯二甲酸丁苄酯,1,2-benzenedicarboxylic acid,butyl phenylmethyl ester,Butyl benzyl phthalate

Target: Others, Aryl Hydrocarbon Receptor

Pifithrin-α hydrobromide

Cat.No: T2707

Synonym: Pifithrin hydrobromide,Pifithrin-α (PFTα) HBr,Pifithrin-α,PFTα,PFTα hydrobromide

Target: Ferroptosis, Aryl Hydrocarbon Receptor, p53

AHR antagonist 2

Cat.No: T10269

Target: Aryl Hydrocarbon Receptor

Cat.No: T8980

Target: Aryl Hydrocarbon Receptor

Cat.No: T5541

Synonym: 1-[2-(4-Chloro-phenyl)-vinyl]-3,5-diMeth,PDM 11

Target: AhR

Dibenzothiophene

Cat.No: T0352

Synonym: 二苯并噻吩,Imino semicarbazide,Diphenylene sulfide

Target: Others

Solvent Blue 35

Cat.No: T19057

Synonym: Sudan Blue II,溶剂蓝35,溶剂蓝 35,Oil Blue 35

Target: Others

Cat.No: T0954

Synonym: Narcotane,氟烷,Anestan

Target: Potassium Channel, Chloride channel, GABA Receptor, NMDAR

Cat.No: T10325

Target: Chk

Cat.No: T34298

Synonym: NSC 26317,NSC-26317,NSC26317

Pifithrin-β hydrobromide

Cat.No: T3637

Synonym: Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide)

Target: Ferroptosis, p53

Cat.No: T10526

Target: Others

Cat.No: T36696

Benzyl 2-naphthyl ether

Cat.No: T20307

Synonym: AI3 00945,AI300945,AI3-00945

Dibenzo(a,i)pyrene

Cat.No: T23994

Synonym: DB(a,i)p,Benzo(rst)pentaphene

Cat.No: T24960

Synonym: 10ClBBQ

Cat.No: T25235

Synonym: CHD5

AHR-activator-1023

Cat.No: T23686

Synonym: Branching Morphogenesis Modulator 1023,Cpd 1023,Compound 1023,BMM 1023

Cat.No: T16082

Synonym: YH439

Target: Others

AFP464 free base

Cat.No: T10258

Synonym: NSC710464 free base

Target: HIF

6-Maleimidocaproic acid-PFP ester

Cat.No: T14059

Target: Others

6,2',4'-Trimethoxyflavone

Cat.No: T22528

Target: Others

AHR antagonist 4

Cat.No: T10271

Target: Others

AHR antagonist 5

Cat.No: T10272

Target: Others

Cat.No: T19927

Synonym: Bitumen,Asphalt fumes,Dacholeum

AhR modulator-1

Cat.No: T10273

Target: Others

Cat.No: T70240

Ipatasertib-NH2 dihydrochloride

Cat.No: T38393

Synonym: RG7440-NH2 dihydrochloride,Ipatasertib-NH2 dihydrochloride,GDC-0068-NH2 dihydrochloride

Lauroyl alanine

Cat.No: T20161

Synonym: Lauroylalanine,N-Lauroyl-L-alanine,Aminiosurfact LA

Cat.No: T22725

Target: Others

StemRegenin 1 (hydrochloride)

Cat.No: T23400

Synonym: StemRegenin 1 (hydrochloride) (1227633-49-9 free base)

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN1451	Brevifolincarboxylic acid	AhR; Aryl Hydrocarbon Receptor; Glucosidase	Immunology/Inflammation; Metabolism
	Brevifolincarboxylic acid 是从头状蓼中分离得到的一种天然产物，抑制芳烃受体(AhR)。它是一种 α-葡萄糖苷酶抑制剂，IC50 为 323.46 μM。
T7914	Acenaphthylene	Others	Others
	Acenaphthylene 是多环芳烃。其中多环芳烃是自然衍生于煤和焦油沉积物中，并由有机质的不完全燃烧得到。
T6795	Carbidopa 卡比多巴,(S)-(-)-Carbidopa,Lodosyn	Decarboxylase; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism; Others
	Carbidopa (Lodosyn) 是一种选择性芳香烃受体(AhR)调节剂，是外周型脱羧酶抑制剂，抑制胰腺癌细胞和肿瘤生长，可用于帕金森病的研究。
T4928	L-Kynurenine L-犬尿氨酸,(S)-Kynurenine	AhR; Aryl Hydrocarbon Receptor; Endogenous Metabolite	Immunology/Inflammation; Metabolism
	L-Kynurenine ((S)-Kynurenine) 是L-色氨酸的代谢物，是芳香烃受体激动剂，可抑制同种异体 T 细胞增殖并增加恶性 U87 神经胶质瘤细胞侵入胶原基质。
T0878	Diosmin Venosmine,Diosmil,Barosmin,地奥司明,地奥司明（7-芸香糖甙）	Aryl Hydrocarbon Receptor; Norepinephrine	Immunology/Inflammation; Neuroscience
	Diosmin (Venosmine) 是在各种柑橘类水果中发现的类黄酮，也是芳烃受体激动剂，有增强血管壁的作用。
TN2883	3',4'-Dimethoxyflavone	Others; PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair; Others
	3',4'-Dimethoxyflavone 是类黄酮化合物的参考标准，类黄酮化合物具有多种药用活性。
T4939	Indole-3-pyruvic acid 3-(3-吲哚基)-2-氧代丙酸,3-(3-Indolyl)-2-oxopropanoic acid	Others	Others
	Indole-3-pyruvic acid (3-(3-Indolyl)-2-oxopropanoic acid) 是一种参与Indole-3-acetic acid 生物合成的化合物，Indole-3-acetic acid 是一种植物激素，在调节生长和对环境变化的反应中起重要作用。
T5281	Skatole 粪臭素,Scatole,3-Methylindole,3-Methylindole,3-甲基吲哚,3-Methyl-1H-indole,beta-Methylindole	AhR; p38 MAPK; Aryl Hydrocarbon Receptor; Endogenous Metabolite; Antibacterial; Autophagy; Antifungal	Autophagy; Immunology/Inflammation; MAPK; Metabolism; Microbiology/Virology
	Skatole (3-Methyl-1H-indole) 是由肠道菌群产生的，通过激活芳基烃受体和 p38调节肠上皮细胞功能。
T2947	Indole-3-carbinol 吲哚-3-甲醇,I3C,3-Indolemethanol,3-吲哚甲醇,Indole-3-Methanol	E1/E2/E3 Enzyme; NF-κB; Aryl Hydrocarbon Receptor; Endogenous Metabolite; p53	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB; Ubiquitination
	Indole-3-carbinol (I3C) 是樟子松中的一种天然产物，是可口服的硫代葡萄糖苷葡糖苷酶裂解产物。它是芳烃受体 (AhR) 的激动剂，可抑制 NF-κB 和 IκBα 激酶活化。
TN6925	Pristane 姥鲛烷,2,6,10,14-tetramethylpentadecane	Others	Others
	Pristane (2,6,10,14-tetramethylpentadecane) 是一种天然存在的烃油，是矿物油中最活跃的成分，较少存在于许多植物、各种海洋生物中。它是一种非抗原性佐剂，可诱导大鼠中 MHC II 类限制性关节炎 T 细胞。
T14961	Chrysene 䓛,屈	Others	Others
	Chrysene 是高分子量 (HMW) 多环芳烃，有极强的顽固性和致癌性。
T5226	2-(2-Methylbenzamido)acetic acid 2-Methylhippuric acid,2-甲基马尿酸,O-Toluric acid,N-(O-Toluoyl)glycine	Others; Endogenous Metabolite	Metabolism; Others
	2-(2-Methylbenzamido)acetic acid (O-Toluric acid) 是一种能够在尿液中检测到的代谢物。
TN6835	(E)-β-Farnesene (6E)-7,11-dimethyl-3-methylidenedodeca-1,6,10-triene,trans-β-Farnesene	Antifungal	Microbiology/Virology
	(E)-β-Farnesene (trans-β-Farnesene) 是一种存在于 Phlomis aurea Decne中的倍半萜烃，是许多蚜虫报警信息素的主要成分，可中断蚜虫摄食。(E)-β-Farnesene 通过破坏昆虫激素平衡来损害 Chilo suppressalis 幼虫的发育和存活。
T2864	Lycopene 番茄红素,ψ,ψ-Carotene	Reactive Oxygen Species; ROS	Immunology/Inflammation; Metabolism; NF-κB
	Lycopene (ψ,ψ-Carotene) 是一种番茄及其产品和其他红色水果和蔬菜中天然存在的类胡萝卜素，具有抗氧化活性。
T3776	Rhapontigenin 丹叶大黄素,Protigenin	P450; Antibacterial; Antifungal	Metabolism; Microbiology/Virology
	Rhapontigenin (Protigenin) 是一种基于机制的选择性细胞色素 P450 1A1 (IC50: 400 nM) 灭活剂。它是一种芳烃羟化酶，可激活作为致癌物质的多环芳烃。它是白藜芦醇的天然类似物，具有抗癌，抗氧化剂，抗真菌和抗菌活性。
TN6694	5,6-Benzoflavone β-Naphthoflavone,beta-NF	Antioxidant	oxidation-reduction
	5,6-Benzoflavone (β-Naphthoflavone) 是芳烃受体的外源配体，可破坏人肝癌 HepG2 细胞中的锌稳态。5,6-Benzoflavone (β-Naphthoflavone) 具有抗炎和抗氧化活性，抑制通过 AKT/Nrf-2/HO-1-NF-kappaB 信号转导轴，抑制 LPS 诱导的炎症，抑制TNF-α诱导的ICAM-1和VCAM-1表达，可用于研究神经退行性疾病。
T4938	Potassium 1H-indol-3-yl sulfate 硫酸吲哚钾盐,Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate	AhR; Endogenous Metabolite	Immunology/Inflammation; Metabolism
	Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) 是人芳烃受体(AhR)的激动剂。芳烃受体(AhR)最近被发现是免疫炎症条件的病理生理调节剂，Potassium 1H-indol-3-yl sulfate 已被证明是AhR的配体。Potassium 1H-indol-3-yl sulfate 也是膳食蛋白质中色氨酸的代谢物。色氨酸被肠道细菌代谢为吲哚，吲哚被吸收到血液中，然后在肝脏中进一步代谢为硫酸吲哚，通常通过尿液排出体外。在肾功能受损的慢性肾病患者中，Potassium 1H-indol-3-yl sulfate 可作为尿毒症毒素在血清中积累，诱导氧化应激并加速疾病进展。250 μM Potassium 1H-indol-3-yl sulfate 可诱导NF-Κb活化，促进大鼠近端小管细胞TGF-β1和Smad3的表达，与促纤维化活性相关。
T82897	Benzo[e]pyrene
	Benzo[e]pyrene为化石燃料中检出的多环芳烃(PAHs)类剧毒成员。
TN6366	Lupinalbin A 鲁冰花
	Lupinalbin A as the most potent estrogen receptor α- and aryl hydrocarbon receptor agonist in Eriosema laurentii de Wild. (Leguminosae). It exerts anti-inflammatory effects via the inhibition of pro-inflammatory cytokines and blocking of IFN-β/STAT1 pathw
T78469	α-Copaene
	α-Copaene，一种倍半萜烃，具有水果挥发物性质，可作为橄榄实蝇（Bactrocera oleae）的产卵促进剂。
T75433	Norisoboldine hydrochloride
	Norisoboldine hydrochloride是一种口服活性天然芳基烃受体(AhR)激动剂，作为林参中的主要异喹啉类生物碱，适用于类风湿性关节炎和溃疡性结肠炎的研究。
T73402	Flavipin
	Flavipin 是一种芳香烃受体(Ahr)激动剂，可诱导小鼠 CD4+T 细胞和 CD11b+巨噬细胞表达 Ahr 下游基因。Flavipin 抑制 Arid5a 在 Il23a3'UTR 上的稳定功能，这是一种新发现的靶 mRNA。Flavipin 具有清除 DPPH 自由基的能力，IC50值为7.2 μM，对α-葡萄糖苷酶具有较强的抑制作用，IC50值为 33.8 μM。

天然产物

Brevifolincarboxylic acid

Cat.No: TN1451

Target: AhR, Aryl Hydrocarbon Receptor, Glucosidase

Cat.No: T7914

Target: Others

Cat.No: T6795

Synonym: 卡比多巴,(S)-(-)-Carbidopa,Lodosyn

Target: Decarboxylase, Aryl Hydrocarbon Receptor

Cat.No: T4928

Synonym: L-犬尿氨酸,(S)-Kynurenine

Target: AhR, Aryl Hydrocarbon Receptor, Endogenous Metabolite

Cat.No: T0878

Synonym: Venosmine,Diosmil,Barosmin,地奥司明,地奥司明（7-芸香糖甙）

Target: Aryl Hydrocarbon Receptor, Norepinephrine

3',4'-Dimethoxyflavone

Cat.No: TN2883

Target: Others, PARP

Indole-3-pyruvic acid

Cat.No: T4939

Synonym: 3-(3-吲哚基)-2-氧代丙酸,3-(3-Indolyl)-2-oxopropanoic acid

Target: Others

Cat.No: T5281

Synonym: 粪臭素,Scatole,3-Methylindole,3-Methylindole,3-甲基吲哚,3-Methyl-1H-indole,beta-Methylindole

Target: AhR, p38 MAPK, Aryl Hydrocarbon Receptor, Endogenous Metabolite, Antibacterial, Autophagy, Antifungal

Indole-3-carbinol

Cat.No: T2947

Synonym: 吲哚-3-甲醇,I3C,3-Indolemethanol,3-吲哚甲醇,Indole-3-Methanol

Target: E1/E2/E3 Enzyme, NF-κB, Aryl Hydrocarbon Receptor, Endogenous Metabolite, p53

Cat.No: TN6925

Synonym: 姥鲛烷,2,6,10,14-tetramethylpentadecane

Target: Others

Cat.No: T14961

Synonym: 䓛,屈

Target: Others

2-(2-Methylbenzamido)acetic acid

Cat.No: T5226

Synonym: 2-Methylhippuric acid,2-甲基马尿酸,O-Toluric acid,N-(O-Toluoyl)glycine

Target: Others, Endogenous Metabolite

(E)-β-Farnesene

Cat.No: TN6835

Synonym: (6E)-7,11-dimethyl-3-methylidenedodeca-1,6,10-triene,trans-β-Farnesene

Target: Antifungal

Cat.No: T2864

Synonym: 番茄红素,ψ,ψ-Carotene

Target: Reactive Oxygen Species, ROS

Cat.No: T3776

Synonym: 丹叶大黄素,Protigenin

Target: P450, Antibacterial, Antifungal

5,6-Benzoflavone

Cat.No: TN6694

Synonym: β-Naphthoflavone,beta-NF

Target: Antioxidant

Potassium 1H-indol-3-yl sulfate

Cat.No: T4938

Synonym: 硫酸吲哚钾盐,Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate

Target: AhR, Endogenous Metabolite

Cat.No: T82897

Cat.No: TN6366

Synonym: 鲁冰花

Cat.No: T78469

Norisoboldine hydrochloride

Cat.No: T75433

Cat.No: T73402

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