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WAY-605471

Name: WAY-605471
Brand: TargetMol
SKU: T9822
Price: 463 CNY
Availability: InStock
Rating: 5 (10 reviews)

货号 T9822Cas号 378223-81-5 一键复制产品信息纯度: 99.62%

很棒

WAY-605471是一种 AHR 拮抗剂，IC50为0.5 - 1 μM。

WAY-605471

一键复制产品信息

很棒

纯度: 99.62%

货号 T9822Cas号 378223-81-5

WAY-605471是一种 AHR 拮抗剂，IC50为0.5 - 1 μM。

规格	价格	库存
1 mg	¥ 463	现货
5 mg	¥ 1,070	现货
10 mg	¥ 1,570	现货
25 mg	¥ 2,480	现货
50 mg	¥ 3,400	现货
100 mg	¥ 4,600	现货
1 mL x 10 mM (in DMSO)	¥ 996	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.62%

颜色: 橙色

性状: Solid

资源下载: COA LCMS HNMR产品操作手册

产品介绍

WAY-605471 AI Summary

WAY-605471 exhibits a diverse range of bioactivities across various biological systems. Notably, it increases the expression of NF-kB in Human Neuronal Cells with an EC50 of 952.0 nM and activates STAT1 with an EC50 of 233.0 nM. In addition, it modulates miRNAs, particularly activating miR-21 with a potency of 369.0 nM, and activates the Rab9 Promoter with a potency of 562.3 nM. The compound enhances SMN2 Splice Variant Expression with a potency of 6309.6 nM and inhibits multiple viral activities including Hepatitis C Virus at 10000.0 nM and Foot and Mouth Disease Virus at 891.3 nM. It also shows antiviral potential against SARS-CoV-2 by demonstrating a 21.04% inhibition of 3CL-Pro protease activity at 20 µM and inhibiting cytotoxicity in VERO-6 cells. Furthermore, WAY-605471 inhibits various enzymes and transcriptional activities, such as ROR gamma with a potency of 158.5 nM, and demonstrates potential in inhibiting protein interactions and DNA repair mechanisms. The compound also inhibits Tau Fibril Formation and diverse cellular activities in Drosophila S3 cells, Leukemia models, and other human cell lines..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	WAY-605471 is a AHR antagonist with IC50 of 0.5 - 1 μM.

化学信息

分子量	309.4
分子式	C₁₄H₁₅NO₃S₂
CAS No.	378223-81-5
Smiles	N(C(=O)C1=C(C)C=CS1)C=2SC(C(OCC)=O)=C(C)C2
密度	1.321 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 55 mg/mL (177.76 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2321 mL	16.1603 mL	32.3206 mL	161.6031 mL
5 mM	0.6464 mL	3.2321 mL	6.4641 mL	32.3206 mL
10 mM	0.3232 mL	1.6160 mL	3.2321 mL	16.1603 mL
20 mM	0.1616 mL	0.8080 mL	1.6160 mL	8.0802 mL
50 mM	0.0646 mL	0.3232 mL	0.6464 mL	3.2321 mL
100 mM	0.0323 mL	0.1616 mL	0.3232 mL	1.6160 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。