还可以
StemRegenin 1 is an aryl hydrocarbon receptor signaling antagonist (IC50: 127 nM in CD34+ cells).
还可以StemRegenin 1 is an aryl hydrocarbon receptor signaling antagonist (IC50: 127 nM in CD34+ cells).
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 1 mg | ¥ 852 | 5日内发货 | |
| 5 mg | ¥ 3,712 | 5日内发货 | |
| 10 mg | ¥ 6,547 | 5日内发货 |
| 产品描述 | StemRegenin 1 is an aryl hydrocarbon receptor signaling antagonist (IC50: 127 nM in CD34+ cells). |
| 体外活性 | In vitro: In a previous study, the unbiased screen with primary human HSCs identified the StemRegenin 1 (SR1), which could promote the ex-vivo expansion of CD34+ cells. In addition, the culture of HSCs with SR1 resulted in a 50-fold increase in cells expressing CD34. Moreover, the mechanistic studies showed that SR1 acted by antagonizing the AhR [1]. |
| 体内活性 | In vivo: In an animal study, 300 to 30,000 uncultured CB CD34+ cells were transplanted into NSG mice. Results showed that CB CD34+ cells cultured with SR1 led to significant increases in human engraftment in the peripheral blood at 1 week, compared with mice transplanted with 10,000 uncultured cells or the progeny of 10,000 control cells [1]. |
| 别名 | StemRegenin 1 (hydrochloride) (1227633-49-9 free base) |
| 分子量 | 466 |
| 分子式 | C24H23N5OS·HCl |
| CAS No. | 2319882-01-2 |
| 密度 | no data available |
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度信息 | DMSO: ≤5 mg/mL, Sonication is recommended. |
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 一共给药动物 10 只 ，您使用的配方为 5% 
DMSO+ 30%PEG300+ 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为 2 mg/mL 。 母液，添加 300 μLPEG300 混匀澄清，再加 50μLTween 80, 混匀澄清，再加 600μLSaline/PBS/ddH2O 混匀澄清 以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
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