cardiac function

Dapansutrile 是一种口服有活性的 NLRP3 炎性小体选择性抑制剂。它具有抗炎特性，可用于研究缓解疼痛。

Enrasentan（sb-217242）是一种 ET（A） 和 ET（B） 受体的混合拮抗剂，可降低血压、防止心肌肥大和保护心肌功能。

AM-8123 是一种可口服的非肽 APJ 激动剂。AM-8123 可减少胶原蛋白负荷并改善心脏功能。AM-8123 可改善大鼠心肌梗死，可用于研究心力衰竭等心血管疾病。

CBS-1114 HCl (N-Phenylbenzamidrazone hydrochloride) 是一种5-脂氧合酶抑制剂，是一种良好眼睛渗透型号的抗炎化合物。CBS-1114 HCl 可以保持和改善心脏功能，减轻心功能障碍，以及减少患有心血管疾病的受试者的心外膜脂肪组织和 或心包脂肪组织。

Cyclic AMP (cAMP)(Adenosine 3',5'-cyclophosphate) 是有丝分裂信使，可以促进 G1期到 S 期的细胞周期进程。

CBM-301940 (compound 5) 是一种高效和具有口服活性的MCD(Malonyl-CoA Decarboxylase)抑制剂，IC50=23 nM，改善了大鼠心脏缺血 再灌注模型的心脏效率和功能，具有心脏保护功能。

CLT-28643是一种有效和特异性的α5β1-Integrin抑制剂，能够预防青光眼滤过手术（GFS）的纤维化，抑制肿瘤生长和血管生成，在博来霉素诱导的肺纤维化模型中抑制纤维化和炎症，改善肥胖小鼠H9C2细胞的胰岛素敏感性和心脏功能。

SAR296968 is a novel selective NCX inhibitor, improving cardiac function and restoring sympathovagal balance in heart failure.

Danicamtiv (MYK-491) 是一种正性肌力药物，也是一种心肌肌球蛋白的选择性变构激活剂，可增加心脏收缩功能并保持机械效率。

KR-32568是一种钠 氢交换器1（NHE-1）抑制剂（IC50：230 nM）。KR-32568具有强大的心脏保护作用。当使用浓度为10μM 时，它能在离体的缺血大鼠心脏模型中恢复心脏收缩功能。KR-32568（0.3mg kg）在缺血和再灌注损伤的大鼠模型中减少了心肌梗死的大小。

Pyrocatechol sulfate 是一种在人体血浆中发现的酚类代谢物，与摄入浆果等特定食物及肠道菌群状态有关。该化合物可能用作监测肾功能、透析清除率、全谷物与常规咖啡的摄入量的尿液生物标记。同时，Pyrocatechol sulfate 与其他酚类硫酸盐共同参与调节多种生物学功能，这些功能涉及大脑健康与心肌细胞的节律性跳动。

Enrasentan（又名SB-217242）是一种双重受体内皮素拮抗剂，对ET(A)受体具有较高的亲和力。在高血压和心脏肥厚的动物模型中，该化合物降低了血压，预防了心脏肥厚，并保持了心肌功能。Enrasentan提高了存活率，限制了左心室重塑，并在高血压心脏肥厚和功能障碍中保持了心肌表现。

Ginkgolide C (BN-52022) 是从银杏叶中分离到的一种黄酮类天然产物，可增强体内大鼠的心脏功能，具有减少血小板聚集，改善阿尔兹海默症等作用。

Epothilone F is a derivative or analogue of Epothilone D. Epothilone F is also an active metabolite of Epothilone D. In molecule of Epothilone F, a hydroxymethyl group is on the thiazole ring. Like taxanes, Epothilone F prevents cancer cells from dividing

ML 7 is an inhibitor of myosin light chain kinase that protects cardiac function from ischemia reperfusion (I R) injury.

3-Iodothyronamine is derived from the deiodination and decarboxylation of endogenous thyroxine. It activates the G protein-coupled receptor known as trace amine-associated receptor 1 at nanomolar concentrations whereupon it rapidly influences thyroid hormone actions including body temperature, heart rate, and cardiac output. It has also been reported to function in controlling lipid and glucose utilization, hormonal secretion, and neuronal function, and has been considered for use in chemically-induced hibernation for medical purposes.

Forsythoside B 是传统中药植物独一味叶子中分离的一种苯乙醇苷。它可抑制 TNF-alpha，IL-6，IκB， 调节 NF-κB。它抑制炎症反应，具有抗氧化和神经保护作用。

APJ Receptor Agonist 4 is a potent, orally active apelin receptor (APJ) agonist, demonstrating an EC50 of 0.06 nM and a Ki of 0.07 nM. It exhibits excellent pharmacokinetic profiles in rodent heart failure (HF) models and has shown an acceptable safety profile in preclinical toxicology studies. This compound effectively improves cardiac function, making it valuable for research into HF disease.

CXL-1020 是一种硝酰 (HNO) 前体药物。CXL-1020 改善舒张异常大鼠的心肌收缩性 舒张性和 Ca2+循环。CXL-1020 在犬模型中诱导血管舒张并改善心脏功能。CXL-1020 已被用于研究收缩期心力衰竭和稳定期心力衰竭。

APJ receptor agonist 5 (compound 3) 是一种有效的、口服具有活力的 apelin 受体 (APJ) 激动剂 (EC50: 0.4 nM)。APJ receptor agonist 5 在啮齿动物心力衰竭 (HF) 模型中具有出色的药代动力学特征，在临床前毒理学研究中也具有可接受的安全性。APJ receptor agonist 5 能够改善心脏功能，可用于 HF 疾病的研究。

KR-39038 是一种口服具有活力的 GRK5 (G 蛋白偶联受体激酶 5) 抑制剂 (IC50: 0.02 μM)。KR-39038 能够抑制新生儿心肌细胞的 HDAC5 通路，明显抑制血管紧张素 II 诱导的细胞肥大，具有显著的抗心肌肥厚和改善心功能作用。KR-39038 能够用于进行心力衰竭的研究。

Wnt signaling is required for direct multiple biological processes and also plays key roles in the pathogenesis of various diseases. Cyclic AMP response element-binding protein (CREB) is a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Via generating a transcriptionally active complex with β-catenin, CREB acts as a mediator of Wnt signaling.ICG-001 is an inhibitor of β-catenin CREB mediated transcription. The direct cellular target of ICG-001 is CREB. the inhibitory IC50of ICG-001 against β-catenin CREB mediated transcription was 3 μM. ICG-001 treatment at the concentration of 25 μM for 24h significantly increased caspase activity in both colon cancer cell lines SW480 and HCT116 cell lines but not in normal colonic epithelial cells CCD-841Co. In a cell growth inhibition assay, the IC50s of ICG-001 against SW480 and HCT116 cells were 4.43 μM and 5.95 μM, respectively.In a SW620 nude mouse xenograft model, an water-soluble analog of ICG-001 given at the dose of 150 mg kg i.v. once in every 2 days dramatically suppressed tumor growth. In a bleomycin-induced pulmonary fibrosis mice model, ICG-001 given at the dose of 5 mg kg per day reversed pulmonary fibrosis. In a rat myocardial infarction model, ICG-001 was administrated subcutaneously at the dose of 50 mg kg day for 10 days which significantly improved cardiac contractile function after myocardial infarction in the rats.

F 15845 is a blocker of the persistent sodium current prevents consequences of hypoxia in rat femoral artery. F15845 has been shown to selectively inhibit the persistent sodium current of Nav1.5[1] exerting cardioprotective effects following ischemia. In vitro testing showed minimal effects of F15845 on other important ion channels of the heart, including major Ca2+ and K+ channels.[1] This characteristic is thought to account for the limited effect of F15845 to change other heart parameters such as basal cardiac function, hemodynamic functions and ventricular fibrillation. F15845 was also shown to exert improved effects when the membrane potential was depolarized,[1] by acting on the extracellular side of the channel.

KB-R7785 is a novel ADAM12 and MMP inhibitor, ameliorating cardiac function in a transverse aortic constriction (TAC) model by inhibiting the proteolytic activation of HB-EGF signaling, exerting its antidiabetic effect by ameliorating insulin sensitivity through the inhibition of TNF-alpha production.