lipid-conjugated

Brincidofovir (HDP-CDV) 是 Cidofovir 的一种具有口服活性的亲脂性形式的前体药物，是一种口服长效的抗病毒药物，有广泛的抗 DNA 病毒活性。

Elacytarabine (M7594 0037) 是核苷类似物阿糖胞苷的一种脂质缀合衍生物。Elacytarabine (M7594 0037) (CP 4055) 是一种抗肿瘤药物，在实体瘤中具有细胞毒性。

DSPE-PEG(2000)-biotin 是一种对1,2-二硬脂酰-sn-甘油-3-PE进行PEG化和生物素化处理的化合物。它被广泛应用于体外和体内的脂质体输送、荧光标记纳米结构脂质载体（NLCs）的开发。此外，DSPE-PEG(2000)-biotin 也用于生成胶束，用作固定脂质体的前体，并被应用于生物层干涉测量结合实验中。当含有DSPE-PEG(2000)-biotin的脂质体内封装有多柔比星和槲皮素时，能对体外的MCF-7 adr多药耐药乳腺癌细胞产生细胞毒作用，并有效抑制MCF-7 adr小鼠移植瘤模型中的肿瘤增长。通过使用生物素偶联的FITC标记的avidin，已成功在NLCs中实现荧光标记。

Tenofovir exalidex (CMX 157) 是一种非环核苷酸类似物 Tenofovir 的脂质结合物，对野生型和抗逆转录病毒耐药的 HIV 毒株，包括多药核苷 核苷酸类似物耐药病毒，都有活性。Tenofovir exalidex 对人外周血单个核细胞中所有主要的HIV-1和HIV-2亚型以及单核细胞来源的巨噬细胞中所有 HIV-1 菌株具有活性，EC50 范围在 0.2 和 7.2 nM 之间。Tenofovir exalidex 具有口服活性，无明显毒性。Tenofovir exalidex 对 HBV 也有活性。

1-Pentadecanoyl-rac-glycerol is a monoacylglycerol that contains pentadecanoic acid at the sn-1 position. It has been found in wheat bran extracts.1 1-Pentadecanoyl-rac-glycerol levels are increased in a HepaRG cell-based model of hepatic steatosis induced by BSA-conjugated palmitate.2 |1. Prinsen, P., Gutiérrez, A., Faulds, C.B., et al. Comprehensive study of valuable lipophilic phytochemicals in wheat bran. J. Agric. Food Chem. 62(7), 1664-1673 (2014).|2. Brown, M.V., Compton, S.A., Milburn, M.V., et al. Metabolomic signatures in lipid-loaded HepaRGs reveal pathways involved in steatotic progression. Obesity (Silver Spring) 21(12), E561-E570 (2013).

9(Z),11(E)-Conjugated linoleic acid is an isomer of linoleic acid that has been found in beef and milk fat.1It binds to peroxisome proliferator-activated receptor α (PPARα; IC50= 140 nM) and activates the receptor in a reporter assay using COS-1 cells expressing mouse PPARα when used at a concentration of 100 μM.29(Z),11(E)-Conjugated linoleic acid inhibits TNF-α-inducedGLUT4expression and increases insulin-stimulated glucose transport in 3T3-L1 adipocytes.3Dietary administration of 9(Z)11(E)-conjugated linoleic acid reduces serum fasting glucose, insulin, and triglyceride levels and decreases white adipose tissue macrophage infiltration inob obmice. It also increases body weight gain and body fat in weanling mice.4[Matreya, LLC. Catalog No. 1278] 1.Shultz, T.D., Chew, B.P., Seaman, W.R., et al.Inhibitory effect of conjugated dienoic derivatives of linoleic acid and β-carotene on the in vitro growth of human cancer cellsCancer Lett.63(2)125-133(1992) 2.Moya-Camarena, S.Y., Heuvel, J.P.V., Blanchard, S.G., et al.Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARαJ. Lipid Res.40(8)1426-1433(1999) 3.Moloney, F., Toomey, S., Noone, E., et al.Antidiabetic effects of cis-9, trans-11-conjugated linoleic acid may be mediated via anti-inflammatory effects in white adipose tissueDiabetes56(3)574-582(2007) 4.Pariza, M.W., Park, Y., and Cook, M.E.The biologically active isomers of conjugated linoleic acidProg. Lipid Res.40(4)283-298(2001)

DEPMPO is a nitrone that is used to spin trap reactive O-, N-, S-, and C-centered radicals and allow their characterization when used in association with electron spin resonance. It is noted for the stability of adducts formed. DEPMPO can be used in vitro or in vivo, as it crosses lipid bilayer membranes and is a good trapping agent in biological systems. DEPMPO-biotin is a biotinylated form of DEPMPO which retains the outstanding persistency of its adducts. The biotin moiety offers an effective means for monitoring biodistribution in cells, tissues, and organs when used with an avidin-conjugated reporter. Importantly, DEPMPO-biotin binds free radicals, such as S-nitroso groups, on proteins, producing adducts that can be analyzed via the biotin tag. This direct labeling of S-nitrosothiols (SNO) thus serves as an effective alternative to the more cumbersome biotin-switch method for monitoring SNO formation.

Lipoxin A4 methyl ester (LXA4 methyl ester) is a more lipid soluble, prodrug formulation of the transcellular metabolite LXA4. LXA4 is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of 15-HETE or 15-HpETE with human leukocytes.[1] LXA4 is equipotent to leukotriene B4 (LTB4) in inducing superoxide generation in human neutrophils at 0.1 μM.[2] LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion.[2],[3],[4]

3β-OH-7-Oxocholenic acid is a bile acid.1 It is also a metabolite of 7β-hydroxy cholesterol in rats. Conjugated forms of 3β-OH-7-oxocholenic acid have been found in the urine of patients with Neimann-Pick disease type C.2,3 |1. Norii, T., Yamaga, N., and Yamasaki, K. Metabolism of 7β-hydroxycholesterol-4-14C in rat. Steroids 15(3), 303-326 (1970).|2. Alvelius, G., Hjalmarson, O., Griffiths, W.J., et al. Identification of unusual 7-oxygenated bile acid sulfates in a patient with Niemann-Pick disease, type C. J. Lipid Res. 42(10), 1571-1577 (2001).|3. Maekawa, M., Omura, K., Sekiguchi, S., et al. Identification of two sulfated cholesterol metabolites found in the urine of a patient with Niemann-Pick disease type C as novel candidate diagnostic markers. Mass Spectrom. (Tokyo) 5(2), S0053 (2016).

DSPE-PEG(2000)-amine is a PEGylated derivative of 1,2-distearoyl-sn-glycero-3-PE . It has been used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents.1,2,3DSPE-PEG(2000)-amine has also been used in the synthesis of fluorescein isothiocyanate-loaded mesoporous silica nanoparticles for imaging applications.4It can be conjugated to a variety of functional molecules for improved cellular targeting and uptake of DSPE-PEG(2000)-amine-containing nanoparticles.4,5 1.Sloat, B.R., Sandoval, M.A., Li, D., et al.In vitro and in vivo anti-tumor activities of a gemcitabine derivative carried by nanoparticlesInt. J. Pharm.409(1-2)278-288(2011) 2.Abd-Rabou, A.A., Bharali, D.J., and Mousa, S.A.Taribavirin and 5-fluorouracil-loaded pegylated-lipid nanoparticle synthesis, p38 docking, and antiproliferative effects on MCF-7 breast cancerPharm. Res.35(4)76(2018) 3.Affram, K., Udofot, O., Singh, M., et al.Smart thermosensitive liposomes for effective solid tumor therapy and in vivo imagingPLoS One12(9):e0815116(2017) 4.Wang, L.-S., Wu, L.-C., Lu, S.-Y., et al.Biofunctionalized phospholipid-capped mesoporous silica nanoshuttles for targeted drug delivery: Improved water suspensibility and decreased nonspecific protein bindingACS Nano4(8)4371-4379(2010) 5.Wen, X., Wang, K., Zhao, Z., et al.Brain-targeted delivery of trans-activating transcriptor-conjugated magnetic PLGA lipid nanoparticlesPLoS One9(9):e106652(2014)

1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) is a biotinylated phospholipid. It has been used in PEGylated polyamidoamine-dendrimer-conjugated supported lipid bilayers (SLB) to isolate circulating tumor cells and tumor cell microembolis from patient-derived blood by antibody-coated microfluidics. [1] It has also been used as a component of SLBs to detect protein-ligand binding with ortho-conjugated Texas Red DHPE. [2] In addition, 1,2-dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) has been used in SLBs partitioned into nanowells to create DNA curtains, which can be used as a high-throughput tool for detection of protein-DNA interactions at the single molecule level.[3]

9(Z),11(E),13(E)-Octadecatrienoic Acid ethyl ester (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil. α-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats. It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, α-ESA induced apoptosis through up-regulation of GADD45, p53, and PPARγ. In DLD-1 cells supplemented with α-ESA, apoptosis was induced via lipid peroxidation with an EC50 of 20 μM. It also inhibits DNA polymerases and topoisomerases with IC50s ranging from ~5-20 μM for different isoforms of the enzymes. α-ESA ethyl ester is a neutral, more lipid soluble form of the free acid.

Methyl alpha-eleostearate (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil. α-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats. It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, α-ESA induced apoptosis through up-regulation of GADD45, p53, and PPARγ. In DLD-1 cells supplemented with α-ESA, apoptosis was induced via lipid peroxidation with an EC50 of 20 μM. It also inhibits DNA polymerases and topoisomerases with IC50s ranging from ~5-20 μM for different isoforms of the enzymes. α-ESA methyl ester is a neutral, more lipid soluble form of the free acid.

Steryl glucosides are neutral glycolipids commonly found in plant cell membranes and vegetable oils that contain a glucose moiety conjugated to a sterol lipid. They function as glucose donors in the biosynthesis of glucocerebrosides in plant microsomes and are metabolic precursors to acylated esterified steryl glucosides. Steryl glucosides are the major component of filter- and engine-damaging precipitates formed during biodiesel production from transesterification of vegetable oils. This product contains a mixture of steryl glucosides.

Spike binding peptide 1 (SBP1) 为对应于血管紧张素转换酶2 (ACE2) 的第21至43位氨基酸的肽。已将脂质纳米粒子 (LNPs) 包裹的抗病毒化合物奥司他韦磷酸盐与SBP1结合并通过体外研究评估其控制释放奥司他韦磷酸盐的长期潜力。SBP1 (2%) 固定于交联的羟基丙烯酸酯和乙基黄原酸乙酯网络，提高了对严重急性呼吸系统冠状病毒2(SARS-CoV-2)刺突糖蛋白，亦称表面糖蛋白，的网络捕获效率。

DSPE-PEG-Folate, MW 2000 是一种包含叶酸的 PEG 衍生物，具有靶向性，能结合癌细胞中的叶酸受体。它能够形成胶束或脂质双层，适用于靶向给药系统的研究。

DPPE-PEG550 是一种用于设计共轭聚合物纳米颗粒的合成脂质体 (LPs) 的 PEG 脂质功能端基。脂质体纳米颗粒 (LNPs) 通过生物素修饰和羧基端可以进一步与其他生物分子耦合。功能化的纳米颗粒适用于特定细胞蛋白的靶向标记。以链霉亲和素作为连接体，生物素化的 PEG 脂质缀合聚合物纳米颗粒能够与细胞表面受体上的生物素化抗体结合，从而在荧光成像和传感方面具有应用价值。

DPPE-PEG750 是用于合成脂质体的 PEG 脂质功能端基，可设计用于构建共轭聚合物纳米颗粒。脂质体纳米颗粒 (LNPs) 通过生物素修饰和羧基端方便与其他生物分子耦合。功能化的纳米颗粒适用于特定细胞蛋白的靶向标记。利用链霉亲和素作为连接体，生物素化的 PEG 脂质缀合聚合物纳米颗粒能够与细胞表面受体上的生物素化抗体结合，具备基于荧光的成像和传感的应用价值。

DPPE-PEG1000 是一种用于合成脂质体 (LPs) 的 PEG 脂质功能端基，用于设计共轭聚合物纳米颗粒。脂质体纳米颗粒 (LNPs) 通过生物素修饰和羧基端，能够进一步与其他生物分子耦合。功能化的纳米颗粒可实现特定细胞蛋白的靶向标记。借助链霉亲和素连接，生物素化的 PEG 脂质缀合聚合物纳米颗粒能够结合到细胞表面受体上的生物素化抗体，展示了荧光成像和传感的实用性。

DPPE-PEG3000 是一种用于合成脂质体 (LPs) 的 PEG 脂质功能端基，用于设计共轭聚合物纳米颗粒。这些脂质体纳米颗粒 (LNPs) 通过生物素修饰和羧基端，可进一步与其他生物分子耦合。功能化后的纳米颗粒可以用于特定细胞蛋白质的靶向标记。利用链霉亲和素作为连接体，生物素化的 PEG 脂质缀合聚合物纳米颗粒能够结合到细胞表面受体上的生物素化抗体上，从而实现基于荧光的成像和传感应用。

DPPE-PEG5000 是一种用于合成脂质体 (LPs) 的 PEG 脂质功能端基，适合设计共轭聚合物纳米颗粒。脂质体纳米颗粒 (LNPs) 通过生物素修饰和羧基端，便于与其他生物分子进一步耦合。这些功能化的纳米颗粒可用于靶向标记特定细胞蛋白。借助链霉亲和素作为连接体，生物素化的 PEG 脂质缀合聚合物纳米颗粒能够与细胞表面受体上的生物素化抗体结合，从而实现基于荧光的成像和传感应用。

18:0 mPEG350 PE (ammonium) 是一种用于合成脂质体 (LPs) 的 PEG 脂质功能端基，专门用于设计共轭聚合物纳米颗粒。这些脂质体纳米颗粒 (LNPs) 通过生物素修饰和羧基端与其他生物分子耦合。功能化纳米颗粒能够靶向标记特定细胞蛋白。以链霉亲和素为连接体，生物素化的 PEG 脂质缀合聚合物纳米颗粒能够与细胞表面受体上的生物素化抗体结合，实现荧光成像和传感的应用。

18:0 mPEG550 PE (ammonium) 是一种用于合成脂质体 (LPs) 的 PEG 脂质功能端基，在共轭聚合物纳米颗粒设计中有应用。脂质体纳米颗粒 (LNPs) 具有生物素修饰和羧基端，可进一步与其他生物分子耦合。功能化的纳米颗粒可以用于特定细胞蛋白的靶向标记。通过链霉亲和素作为连接体，生物素化的 PEG 脂质缀合聚合物纳米颗粒能够结合到细胞表面受体上的生物素化抗体，实现基于荧光的成像和传感。

18:0 mPEG750 PE (ammonium) 是一种用于合成脂质体(LPs)的PEG脂质功能端基，专为设计共轭聚合物纳米颗粒而制。脂质体纳米颗粒(LNPs)通过生物素修饰和羧基端可进一步与其他生物分子结合。功能性纳米颗粒用于特定细胞蛋白的靶向标记。利用链霉亲和素作为连接体，生物素化的PEG脂质缀合的聚合物纳米颗粒能够与细胞表面受体上的生物素化抗体结合，从而实现荧光成像和传感的应用。