Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TL02-59 是 Src 家族激酶中 Fgr 的特异性抑制剂 (IC50 = 0.03 nM)。 TL02-59 抑制 Lyn 和 Hck,IC50 分别为 0.1 nM 和 160 nM。 TL02-59 有效抑制急性髓性白血病细胞的生长。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 838 | 现货 | ||
5 mg | ¥ 2,260 | 现货 | ||
10 mg | ¥ 3,560 | 现货 | ||
25 mg | ¥ 5,770 | 现货 | ||
50 mg | ¥ 7,870 | 现货 | ||
100 mg | ¥ 10,800 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,990 | 现货 |
产品描述 | TL02-59 is a selective inhibitor of Fgr in Src-family kinase (IC50 = 0.03 nM). TL02-59 inhibits Lyn and Hck with IC50s of 0.1 nM and 160 nM, respectively. TL02-59 potently suppresses acute myelogenous leukemia cell growth. |
靶点活性 | Fgr:0.03 nM , Hck:160 nM , Lyn:0.1 nM |
体外活性 | TL02-59 inhibits the growth and induced apoptosis of AML cell lines expressing this kinase with single-digit nM potency. TL02-59 induces growth arrest in primary AML bone marrow samples. In TF-1 myeloid cells, TL02-59 (0.1, 1, 10, 100, 1000 nM; 6 h) potently inhibits Fgr autophosphorylation in TF-1 cells, with paritial inhibition at 0.1-1 nM and complete inhibition above 10 nM. Hck, Lyn and Flt3 are inhibited in the 100 to 1000 nM range[1]. |
体内活性 | In mice, TL02-59 (1, 10 mg/kg; oral) completely eliminates AML cells from the spleen and peripheral blood while dramatically suppressing bone marrow involvement. TL02-59 has a t1/2 of 5.7 h by i.v and 6.5 h by p.o., respectively[1]. |
分子量 | 609.64 |
分子式 | C32H34F3N5O4 |
CAS No. | 1315330-17-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 120 mg/mL (196.84 mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.6403 mL | 8.2016 mL | 16.4031 mL | 41.0078 mL |
5 mM | 0.3281 mL | 1.6403 mL | 3.2806 mL | 8.2016 mL | |
10 mM | 0.164 mL | 0.8202 mL | 1.6403 mL | 4.1008 mL | |
20 mM | 0.082 mL | 0.4101 mL | 0.8202 mL | 2.0504 mL | |
50 mM | 0.0328 mL | 0.164 mL | 0.3281 mL | 0.8202 mL | |
100 mM | 0.0164 mL | 0.082 mL | 0.164 mL | 0.4101 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
TL02-59 1315330-17-6 Angiogenesis Apoptosis Tyrosine Kinase/Adaptors Src Hck TL-02-59 Inhibitor Lyn leukemia inhibit acute orally AML TL02 59 TL0259 myelogenous Fgr inhibitor