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Search Results for " trk "
Targets Recommended: Trk receptor Discoidin Domain Receptor (DDR)

80

抑制剂 & 化合物

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Cat. No. Product Name Target Signaling Pathways
T10984 DDR-TRK-1

Discoidin Domain Receptor (DDR) Tyrosine Kinase/Adaptors
DDR-TRK-1 是 DDR1的一个选择性抑制剂，其 IC50 值为 9.4 nM。DDR-TRK-1 也抑制 TRK 激酶家族。
T31234 DDR-TRK-1N

DDR-TRK1N,DDRTRK-1N,DDRTRK1N,DDR-TRK 1N,DDR TRK-1N
DDR-TRK-1N is a negative control for DDR-TRK-1.
T34958 TRK-380

TAC301,TAC 301,TAC-301,TRK 380,TRK380
TRK-380 (TAC-301) is an effective and selective β3-adrenergic receptor agonist. TRK-380 improves formalin-induced frequent urination in rats and carbachol-induced bladder contraction in dogs (a decrease of 37.6%).
T40150 Trk-IN-6

Trk-IN-6 shows excellent in vitro potency on a panel of TRK mutants ( IC 50 = 0.2-0.7 nM).
T17169 Trk-IN-4

PF-6683324 isomer

 Trk receptor Tyrosine Kinase/Adaptors
Trk-IN-4 is an effective pan-Trk inhibitor in cell-based assays (IC50s: 1.9 nM, 2.6 nM, and 1.1 nM for TrkA, TrkB, and TrkC, respectively).
T28129 Naltalimide

TRK-130,TRK 130,TRK130
Naltalimide is a unique µ-opioid receptor partial agonist. Naltalimide also enhances the bladder storage function by modulating the afferent limb of the micturition reflex through µ-opioid receptors in the spinal cord.
T62095 TRK-IN-19

TRK-IN-19 (Compound I-10 ) 是一种 TRK 的有效抑制剂，对 TRKA、TRKAG595R 的 IC50 值分别为 1.1 nM、5.3 nM。TRK-IN-19 对癌症疾病表现出潜在的研究价值。
T61247 TRK-IN-16

TRK-IN-16 (WO2012034091A1, compound X-21) is a highly effective TRK inhibitor, targeting protein kinases that are integral to regulating cell growth, differentiation, and various cellular signal transduction processes. This compound shows great potential for research in TRK-related diseases [1].
T61872 Trk-IN-10

Trk-IN-10 (Compound 14j) is a highly effective inhibitor of TRK, with an IC50 of 0.86 nM against TrkA and 6.92 nM against TrkA G595R. As an RTK, Trk plays a crucial role as a drug target in solid tumors. Trk-IN-10 (IC50 = 350 nM against ALK) demonstrates superior selectivity in inhibiting Trk, which has potential implications for toxicity reduction [1].
T62531 TRK-IN-12

TRK-IN-12 (Compound 9e) 是一种大环衍生的有效TRK抑制剂，具有显著的TRKG595R抑制活性 (IC50= 13.1 nM)。在Ba/F3-LMNA-NTRK1细胞系中具有出色的抗增殖效果 (IC50= 0.080 μM)，并且在Ba/F3-LMNA-NTRK1-G595R细胞系中展示了超过对照活性分子LOXO-101的抑制能力 (IC50= 0.646 μM)。
T62561 TRK-IN-17

TRK-IN-17 是一种 TRK 的有效抑制剂。其中原肌球蛋白相关激酶 (Trks) 是受体酪氨酸激酶家族成员，由神经营养因子激活。神经营养因子是一组可溶性生长因子，包括神经生长因子 (NGF)、脑源性神经营养因子 (BDNF) 和神经营养因子-3 (NT-3)，以及神经营养因子-4/5 (NT-4/5)。TRK-IN-17 具有潜力进行癌症疾病的研究。
T63076 IHMT-TRK-284

IHMT-TRK-284 (Compound 34) 是一种有效的、口服具有活力的 type II TRK kinase 抑制剂，能够作用于 TRKA (IC50: 10.5 nM)、TRKB (IC50: 0.7 nM)、TRKC (IC50: 2.6 nM)。IHMT-TRK-284 在激酶组中表现出良好的选择性，体内具有良好的抗肿瘤作用。
T62806 Trk-IN-9

Trk-IN-9 (Compound 12) 是一种 TRK 的有效抑制剂。Trk-IN-9 对 Km-12 细胞系的增殖具有抑制作用。Trk-IN-9 以浓度依赖性方式诱导 Km-12 细胞凋亡。Trk-IN-9 能够抑制 TRK 的磷酸化，并阻断下游通路。Trk-IN-9 具有潜力进行 NTRK 融合癌症的研究。
T63346 TRK-IN-18

TRK-IN-18 是 TRK 的有效抑制剂。其中原肌球蛋白相关激酶 (Trks) 是一种受体酪氨酸激酶家族，由神经营养因子激活，神经营养因子是一组可溶性生长因子，包含神经生长因子 (NGF)、脑源性神经营养因子 (BDNF) 和神经营养因子-3 (NT-3)，以及神经营养因子-4/5 (NT-4/5)。TRK-IN-18 表现出对癌症疾病的研究潜力。
T79706 TRK-IN-24

Trk receptor Tyrosine Kinase/Adaptors
TRK-IN-24（compound 10g）是一种针对Trk Receptor的抑制剂，它对TRKA、TRKC、TRKAG595R、TRKAG667C和TRKAF589L的抑制作用的IC50值分别达到5.21、4.51、6.77、1.42和6.13 nM。该化合物在BaF3-CD74-NTRK1G595R和BaF3-CD74-NTRK1G667C异种移植模型中显示出明显的抗肿瘤活性。此外，TRK-IN-24 能有效抑制携带SF、GK、xDFG等单点突变的Ba/F3细胞增殖，其IC50范围为1.43至47.56 nM。
T62429 TRK-IN-14

TRK-IN-14 是一种 TRK 的有效抑制剂。其中蛋白激酶在控制细胞生长和分化中发挥着关键作用，并负责控制多种细胞信号转导过程。TRK-IN-13 对 TRK 相关疾病表现出研究潜力。
T62428 TRK-IN-13

TRK-IN-13 是一种 TRK 的有效抑制剂。其中蛋白激酶在控制细胞生长和分化中发挥着关键作用，并负责控制多种细胞信号转导过程。TRK-IN-13 对 TRK 相关疾病表现出研究潜力。
T61443 Trk-IN-7

Trk-IN-7 (compound I-6) is a highly potent inhibitor of TRK, exhibiting IC50 values ranging from 0.25-10 nM for TRKA, TRKB, and TRKC, respectively. In addition, Trk-IN-7 demonstrates notable inhibition against EML4-ALK (IC50 <15 nM), as well as ALK G1202R, ALK C1156Y, ALK R1275Q, ALK F1174L, ALK L1197M, and ALK G1269A (IC50 = 5-50 nM) [1].
T78968 TRK-IN-23

Trk receptor Tyrosine Kinase/Adaptors
TRK-IN-23 (compound 24b) 是一款口服活性TRK抑制剂，对TRKA、TRKC、TRKAG595R、TRKAF589L和TRKAG667C 表现出高效的抑制作用，其IC50值分别为0.5 nM、9 nM、14 nM、4.4 nM和4.8 nM。此外，TRK-IN-23 能够诱导含有TRKAG595R和TRKAG667C突变的Ba/F3细胞系进行细胞凋亡(apoptosis)。
T62286 TRK-IN-21

TRK-IN-21 (5n) 是一种口服具有活力的 TRK 抑制剂。TRK-IN-21 能够作用于 TRKAWT (IC50: 0.3 nM)，TRKAG667C (IC50: 2.3 nM)，TRKAF589L (IC50: 0.4 nM)和 TRKAG595 (IC50: 0.5 nM)。TRK-IN-21 能够用于研究癌症。
T61246 TRK-IN-15

TRK-IN-15 (WO2012034091A1, compound X-55) is a highly effective inhibitor of TRK, a protein kinase with crucial involvement in the regulation of cellular growth, differentiation, and signal transduction. Offering significant potential for studying TRK-related diseases, TRK-IN-15 holds promise for advancing research in this field [1].
T62093 Trk-IN-11

Trk-IN-11 (Compound 14h) 是一种 TRK 的有效抑制剂，对 TrkA、TrkA G595R 的 IC50 值分别为 1.4 nM、1.8 nM。其中原肌球蛋白受体激酶 (Trk) 是一种受体酪氨酸激酶 (RTK)，也是实体瘤中关键的药物靶点。Trk-IN-11对癌症疾病表现出研究潜力。
T61712 Trk-IN-8

Trk-IN-8, a powerful TRK inhibitor, demonstrates excellent potency against TRKAa, TRKA(G595R), and TRKC(G623R) with IC50 values of 0.42 nM, 0.89 nM, and 1.5 nM, respectively (WO2021115401A1, compound 3) [1].
T61551 Trk-IN-20

Trk-IN-20 is a 3-vinylindazole derivative compound that effectively inhibits the functions of Trk kinases. It accomplishes this by suppressing the phosphorylation of TrkA, TrkB, and TrkC, with IC50 values of 1.6 nM, 2.9 nM, and 2.0 nM, respectively [1].
T73033 TRK II-IN-1

Trk receptor Tyrosine Kinase/Adaptors
TRKII-IN-1 是一种有效的 II 型TRK抑制剂，对TRKA/B/C及TRKAG667C的IC50分别为3.3、6.4、4.3 和 9.4 nM。此外，TRKII-IN-1 对FLT3、RET和VEGFR2也具有抑制作用，其IC50分别为1.3、9.9 和 71.1 nM。TRKII-IN-1 主要用于TRK驱动的癌症研究。
T63475 Pan-Trk-IN-2

Pan-Trk-IN-2 是小分子 Trks 抑制剂，表现出良好的抗肿瘤效果。
T72931 TRK/ALK-IN-1

TRK/ALK-IN-1 是一种有效的 TRK 和 ALK 双重抑制剂。TRK/ALK-IN-1 在酶促测定中与抗增殖活性非常吻合，对 TRKA、ALKIC50值分别为 2.2、9.3 和 38 nM< sup>WT 和 ALKL1196M。TRK/ALK-IN-1具有研究癌症疾病的潜力。
T64070 Pan-Trk-IN-3

Pan-Trk-IN-3 是一种有效的广谱 Trk 及其耐药突变体抑制剂，能够作用于 TrkA (IC50: 2 nM)、TrkB (IC50: 3 nM)、TrkC (IC50: 2 nM)、TrkAG595R (IC50: 21 nM)、TrkAG667C (IC50: 26 nM)、TrkAG667S (IC50: 5 nM)、TrkAF589L (IC50: 7 nM) 和 TrkCG623R (IC50: 6 nM)。Pan-Trk-IN-3 能够诱导细胞凋亡 (apoptosis)，具有显著的抗肿瘤效果。
T72289 Type II TRK inhibitor 1

Trk receptor Tyrosine Kinase/Adaptors
Type II TRK inhibitor 1 是有效抑制多种TRK融合蛋白及野生型的TRK抑制剂。对携有CD74-TRKAG667C及ETV6-TRKCG696C融合蛋白的Ba/F3细胞表现出抗增殖活性，其IC50值分别为6 nM与1.7 nM。
T14921 CE-245677

Tie-2; Trk receptor Tyrosine Kinase/Adaptors
CE-245677 是可逆的Tie2和TrkA/B 抑制剂，在细胞体系下的IC50值分别为 4.7 和 1 nM。
T7568 LM22A-4

Trk receptor Tyrosine Kinase/Adaptors
LM22A-4 是特异性的tyrosine kinase receptor B 激动剂，常用于研究神经系统疾病。
T5635 CH7057288

Trk receptor Tyrosine Kinase/Adaptors
CH7057288 是选择性TRK 抑制剂。
T6097 GNF-5837

GNF 5837

 Trk receptor; PDGFR; c-Kit Angiogenesis; Tyrosine Kinase/Adaptors
GNF-5837 是一种选择性的，有效的，口服生物利用的泛TRK 抑制剂，在 Ba/F3 细胞中显示出抗增殖作用 (对Tel-TrkC,Tel-TrkB 和Tel-TrkA 的IC50值分别为 7 nM，9 nM 和 11 nM)。
T7435 Selitrectinib

LOXO-195

 Trk receptor Tyrosine Kinase/Adaptors
Selitrectinib (LOXO-195) 是二代原肌凝蛋白相关激酶(TRK)抑制剂，能够作用于 TRKA (IC50:0.6 nM) 和 TRKC (IC50<2.5 nM)。
T14363 AZ-23

AZ 23,AZ23

 Trk receptor Tyrosine Kinase/Adaptors
AZ-23是一种 ATP-竞争性的，口服具有活性的 Trk 激酶 A/B/C 抑制剂，IC50值分别为2 nM (TrkA)，8 nM (TrkB)，24 nM (FGFR1)，52 nM (Flt3)，55 nM (Ret)，84 nM (MuSk)，99 nM (Lck)。
T2359 ANA-12

ANA 12,ANA12

 Trk receptor Tyrosine Kinase/Adaptors
ANA-12 是一种选择性TrkB 拮抗剂，对高亲和力和低亲和力位点的IC50分别为45.6 nM 和41.1 μM。
T6052 GW 441756

Apoptosis; Raf; Trk receptor; CDK Apoptosis; Cell Cycle/Checkpoint; MAPK; Tyrosine Kinase/Adaptors
GW 441756 是一种高特异性神经生长因子受体酪氨酸激酶 a 抑制剂 ，IC50值为 2 nM，可消除 BmK NSPK 诱导神经突生长。
T9123 DS-1205

TAM Receptor Tyrosine Kinase/Adaptors
DS-1205b free base 是有效的AXL 激酶选择性抑制剂，IC50为 1.3 nM。它对MER，MET 和TRKA 也有抑制作用，IC50分别为 63、104 和 407 nM。 它可以抑制细胞迁移和肿瘤生长。
T5995 Larotrectinib

LOXO-101,ARRY-470

 Apoptosis; Trk receptor Apoptosis; Tyrosine Kinase/Adaptors
Larotrectinib (LOXO-101)为ATP竞争性、口服选择性抑制剂，针对原肌凝蛋白相关激酶(TRK)家族受体三个亚型(TRKA，B 和C)展现纳摩尔级别的50%抑制浓度。
T4496 LM22B-10

LM22B10

 ERK; Trk receptor; Akt Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
LM22B-10 是TrkB/TrkC 神经营养因子受体激活剂，诱导体内外TrkB、TrkC、AKT 和ERK 的活化。
T8327 ONO-7475

Trk receptor; TAM Receptor Tyrosine Kinase/Adaptors
ONO-7475 是一种选择性的、有效的、具有口服活性的Axl/Mer 抑制剂。它使 AXL 过表达的EGFR 突变型 NSCLC 细胞对 EGFR-TKIs 敏感，抑制耐药细胞的产生和耐药性的维持。它与 Osimertinib 联合使用，具有用于 EGFR 突变非小细胞肺癌的潜力。
T19649 PF-06273340

PF 6273340,PF 06273340,PF6273340,PF-6273340

 Trk receptor Tyrosine Kinase/Adaptors
PF-06273340 是一种口服具有活力的、具有选择性的外周限制性Trk 泛抑制剂。
T4257 Belizatinib

TSR-011

 Trk receptor; ALK Angiogenesis; Tyrosine Kinase/Adaptors
Belizatinib (TSR-011) 是可口服的ALK 和 TRKA、TRKB、TRKC 双重抑制剂，对野生型重组 ALK 的IC50值为0.7 nM。
T4071 Repotrectinib

TPX-0005,TPX 0005,TPX0005

 Trk receptor; ROS; Src; ALK; ROS Kinase Angiogenesis; Immunology/Inflammation; Tyrosine Kinase/Adaptors
Repotrectinib (TPX-0005) 是ROS1(IC50=0.07 nM) 和TRK(对 TRKA/B/C 的IC50=0.83/0.05/0.1 nM) 抑制剂，能够抑制 WTALK(IC50=1.01 nM)。它具有抗癌作用。
T40019 Thalidomide-5-NH2-CH2-COOH

Others Others
Thalidomide-5-NH2-CH2-COOH (compound 114) 是原肌球蛋白受体激酶的选择性抑制剂。它是 E3 连接酶的配体，具有研究一种或多种疾病的潜力。
T2054 Altiratinib

DCC-2701

 VEGFR; Tie-2; FLT; Trk receptor; c-Met/HGFR Angiogenesis; Tyrosine Kinase/Adaptors
Altiratinib (DCC-2701) 是一种多靶点激酶抑制剂，能够抑制 MET (IC50:2.7 nM)，TIE2 (IC50:8 nM)，VEGFR2 (IC50:9.2 nM)，FLT3 (IC50:9.3 nM)，Trk1 (IC50:0.85 nM)，Trk2 (IC50:4.6 nM) 和 Trk3 (IC50:0.83 nM)。
T6712 Tyrphostin AG 879

AG 879

 Apoptosis; EGFR; Trk receptor; HER; PDGFR Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
Tyrphostin AG 879 (AG 879) 是一种抑制TrKA 磷酸化的酪氨酸激酶抑制剂，IC50为 10 μM。它还是一种选择性ErbB2酪氨酸激酶抑制剂，IC50为 1 μM，具有抗癌活性。
T3678 Entrectinib

RXDX-101,恩曲替尼,NMS-E628

 Trk receptor; ROS; ALK; Autophagy; ROS Kinase Angiogenesis; Autophagy; Immunology/Inflammation; Tyrosine Kinase/Adaptors
Entrectinib (RXDX-101) 是一种可口服的 Trk、ROS1和 ALK 抑制剂，具有抗肿瘤和中枢神经活性，抑制 TrkA、TrkB、TrkC、ROS1 和 ALK 的 IC50值分别为 1、3、5、12 和 7 nM。
T0678 Amitriptyline hydrochloride

Amitriptyline HCl,Tryptizol,盐酸阿米替林,Domical,Annoyltin

 Trk receptor; Sigma receptor; 5-HT Receptor; Serotonin Transporter; Sodium Channel; Adrenergic Receptor; AChR; Norepinephrine; Histamine Receptor GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; Tyrosine Kinase/Adaptors
Amitriptyline hydrochloride (Annoyltin) 是血清素再摄取转运体和去甲肾上腺素再摄取转运体抑制剂，还与多巴胺再摄取转运体结合，其Ki 为 2.58 μM。它也抑制肾上腺素能受体、毒蕈碱受体、组胺受体、5-羟色胺受体。它是TrkA 和TrkA 受体的激动剂，具有强神经营养活性和有抗抑郁作用。
T6880 Larotrectinib sulfate

LOXO-101 sulfate,Larotrectinib (LOXO-101) sulfate,Larotrectinib,LOXO-101 (sulfate),ARRY-470,ARRY-470 (sulfate)

 Apoptosis; Trk receptor Apoptosis; Tyrosine Kinase/Adaptors
Larotrectinib sulfate (LOXO-101 sulfate) 是一种 ATP 竞争性的，口服选择性抑制剂，对原肌凝蛋白相关激酶家族受体的三个亚型具有纳摩尔级别的 50% 抑制浓度。

化合物

DDR-TRK-1
Cat.No: T10984
Synonym:
Target: Discoidin Domain Receptor (DDR)
DDR-TRK-1N
Cat.No: T31234
Synonym: DDR-TRK1N,DDRTRK-1N,DDRTRK1N,DDR-TRK 1N,DDR TRK-1N
Target:
TRK-380
Cat.No: T34958
Synonym: TAC301,TAC 301,TAC-301,TRK 380,TRK380
Target:
Trk-IN-6
Cat.No: T40150
Synonym:
Target:
Trk-IN-4
Cat.No: T17169
Synonym: PF-6683324 isomer
Target: Trk receptor
Naltalimide
Cat.No: T28129
Synonym: TRK-130,TRK 130,TRK130
Target:
TRK-IN-19
Cat.No: T62095
Synonym:
Target:
TRK-IN-16
Cat.No: T61247
Synonym:
Target:
Trk-IN-10
Cat.No: T61872
Synonym:
Target:
TRK-IN-12
Cat.No: T62531
Synonym:
Target:
TRK-IN-17
Cat.No: T62561
Synonym:
Target:
IHMT-TRK-284
Cat.No: T63076
Synonym:
Target:
Trk-IN-9
Cat.No: T62806
Synonym:
Target:
TRK-IN-18
Cat.No: T63346
Synonym:
Target:
TRK-IN-24
Cat.No: T79706
Synonym:
Target: Trk receptor
TRK-IN-14
Cat.No: T62429
Synonym:
Target:
TRK-IN-13
Cat.No: T62428
Synonym:
Target:
Trk-IN-7
Cat.No: T61443
Synonym:
Target:
TRK-IN-23
Cat.No: T78968
Synonym:
Target: Trk receptor
TRK-IN-21
Cat.No: T62286
Synonym:
Target:
TRK-IN-15
Cat.No: T61246
Synonym:
Target:
Trk-IN-11
Cat.No: T62093
Synonym:
Target:
Trk-IN-8
Cat.No: T61712
Synonym:
Target:
Trk-IN-20
Cat.No: T61551
Synonym:
Target:
TRK II-IN-1
Cat.No: T73033
Synonym:
Target: Trk receptor
Pan-Trk-IN-2
Cat.No: T63475
Synonym:
Target:
TRK/ALK-IN-1
Cat.No: T72931
Synonym:
Target:
Pan-Trk-IN-3
Cat.No: T64070
Synonym:
Target:
Type II TRK inhibitor 1
Cat.No: T72289
Synonym:
Target: Trk receptor
CE-245677
Cat.No: T14921
Synonym:
Target: Tie-2, Trk receptor
LM22A-4
Cat.No: T7568
Synonym:
Target: Trk receptor
CH7057288
Cat.No: T5635
Synonym:
Target: Trk receptor
GNF-5837
Cat.No: T6097
Synonym: GNF 5837
Target: Trk receptor, PDGFR, c-Kit
Selitrectinib
Cat.No: T7435
Synonym: LOXO-195
Target: Trk receptor
AZ-23
Cat.No: T14363
Synonym: AZ 23,AZ23
Target: Trk receptor
ANA-12
Cat.No: T2359
Synonym: ANA 12,ANA12
Target: Trk receptor
GW 441756
Cat.No: T6052
Synonym:
Target: Apoptosis, Raf, Trk receptor, CDK
DS-1205
Cat.No: T9123
Synonym:
Target: TAM Receptor
Larotrectinib
Cat.No: T5995
Synonym: LOXO-101,ARRY-470
Target: Apoptosis, Trk receptor
LM22B-10
Cat.No: T4496
Synonym: LM22B10
Target: ERK, Trk receptor, Akt
ONO-7475
Cat.No: T8327
Synonym:
Target: Trk receptor, TAM Receptor
PF-06273340
Cat.No: T19649
Synonym: PF 6273340,PF 06273340,PF6273340,PF-6273340
Target: Trk receptor
Belizatinib
Cat.No: T4257
Synonym: TSR-011
Target: Trk receptor, ALK
Repotrectinib
Cat.No: T4071
Synonym: TPX-0005,TPX 0005,TPX0005
Target: Trk receptor, ROS, Src, ALK, ROS Kinase
Thalidomide-5-NH2-CH2-COOH
Cat.No: T40019
Synonym:
Target: Others
Altiratinib
Cat.No: T2054
Synonym: DCC-2701
Target: VEGFR, Tie-2, FLT, Trk receptor, c-Met/HGFR
Tyrphostin AG 879
Cat.No: T6712
Synonym: AG 879
Target: Apoptosis, EGFR, Trk receptor, HER, PDGFR
Entrectinib
Cat.No: T3678
Synonym: RXDX-101,恩曲替尼,NMS-E628
Target: Trk receptor, ROS, ALK, Autophagy, ROS Kinase
Amitriptyline hydrochloride
Cat.No: T0678
Synonym: Amitriptyline HCl,Tryptizol,盐酸阿米替林,Domical,Annoyltin
Target: Trk receptor, Sigma receptor, 5-HT Receptor, Serotonin Transporter, Sodium Channel, Adrenergic Receptor, AChR, Norepinephrine, Histamine Receptor
Larotrectinib sulfate
Cat.No: T6880
Synonym: LOXO-101 sulfate,Larotrectinib (LOXO-101) sulfate,Larotrectinib,LOXO-101 (sulfate),ARRY-470,ARRY-470 (sulfate)
Target: Apoptosis, Trk receptor
Cat. No. Product Name Target Signaling Pathways
T2816 7,8-Dihydroxyflavone

二羟基黄酮水合物,7,8-DHF

 Apoptosis; Trk receptor Apoptosis; Tyrosine Kinase/Adaptors
7,8-Dihydroxyflavone (7,8-DHF) 是一种选择性有效的TrkB 激动剂，其模拟脑源性神经营养因子的生理作用。它有潜力研究各种神经疾病。
T1354 N-Acetyl-5-hydroxytryptamine

Normelatonin,N-乙酰-5-羟色胺,O-Demethylmelatonin,N-Acetylserotonin

 Trk receptor; Endogenous Metabolite Metabolism; Tyrosine Kinase/Adaptors
N-Acetyl-5-hydroxytryptamine (O-Demethylmelatonin) 是褪黑激素的直接前体，能够有效激活TrkB 受体。
T1716 Echinacoside

Reactive Oxygen Species; Wnt/beta-catenin Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; NF-κB; Stem Cells
Echinacoside 是一种从Cistanche salsa 中分离的苯乙醇类化合物，抑制Wnt/β-catenin 信号通路。它能够激活 Trk 受体及其下游信号通路而起到神经保护作用，还具有显著的抗骨质疏松作用。

天然产物

7,8-Dihydroxyflavone
Cat.No: T2816
Synonym: 二羟基黄酮水合物,7,8-DHF
Target: Apoptosis, Trk receptor
N-Acetyl-5-hydroxytryptamine
Cat.No: T1354
Synonym: Normelatonin,N-乙酰-5-羟色胺,O-Demethylmelatonin,N-Acetylserotonin
Target: Trk receptor, Endogenous Metabolite
Echinacoside
Cat.No: T1716
Synonym:
Target: Reactive Oxygen Species, Wnt/beta-catenin
Species：
Human (13)
Canine (4)
Mouse (4)
Rat (4)
Cynomolgus (1)
Rabbit (1)
Expression System：
HEK293 Cells (26)
E. coli (1)
Tag：
C-His (15)
C-hFc (5)
His, hFc (3)
N-His (3)
N-hFc (1)
Cat. No. Product Name Species Expression System
TMPY-01084 TrkA Protein, Human, Recombinant (His)

TRK1,TRK,TRKA,neurotrophic tyrosi...

 Human HEK293 Cells
TrkA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.5 kDa and the accession number is P04629-1.
TMPY-00751 TrkB Protein, Human, Recombinant (His)

trk-B,GP145-TrkB/GP95-TrkB,neurot...

 Human HEK293 Cells
TrkB Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.7 kDa and the accession number is Q16620-2.
TMPY-02231 TrkB Protein, Mouse, Recombinant (His)

trk-B,neurotrophic tyrosine kinase, receptor, type ...

 Mouse HEK293 Cells
TrkB Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46 kDa and the accession number is P15209-2.
TMPY-01760 TrkA Protein, Human, Recombinant (aa 194-413, His)

neurotrophic tyrosine kinase, receptor, type 1,MTC,Trk

Human HEK293 Cells
TrkA Protein, Human, Recombinant (aa 194-413, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is P04629-1.
TMPK-00774 TrkA Protein, Human, Recombinant (aa 33-417, His)

TrkAI,TrkA I,Trk-A,TRKA,...

 Human HEK293 Cells
TrkA, a tyrosine kinase receptor, is an essential component of the nerve growth factor (NGF) response pathway. The binding of NGF to the receptor induces receptor autophosphorylation and activation of intracellular signaling pathways, resulting in diverse biological effects.
TMPY-01759 TrkA Protein, Human, Recombinant (aa 285-413, His)

neurotrophic tyrosine kinase, receptor, type 1,p140-Trk<...

 Human E. coli
TrkA Protein, Human, Recombinant (aa 285-413, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 15.1 kDa and the accession number is P04629-1.
TMPY-01083 TrkA Protein, Human, Recombinant (His & hFc)

TRKA,p140-TrkA,MTC,Trk-A,TRK<...

 Human HEK293 Cells
TrkA Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 66 kDa and the accession number is P04629-1.
TMPY-03536 TrkA Protein, Mouse, Recombinant (His)

neurotrophic tyrosine kinase, receptor, type 1,trk,...

 Mouse HEK293 Cells
TrkA Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.7 kDa and the accession number is Q3UFB7.
TMPY-03470 TrkA Protein, Mouse, Recombinant (hFc)

TrkA,C80751,neurotrophic tyrosine kinase, receptor,...

 Mouse HEK293 Cells
TrkA Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 69.2 kDa and the accession number is Q3UFB7.
TMPY-05509 TrkB Protein, Human, Recombinant (hFc)

GP145-TrkB/GP95-TrkB,trk-B,neurot...

 Human HEK293 Cells
TrkB Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 70.9 kDa and the accession number is Q16620-2.
TMPY-02484 SLITRK4 Protein, Human, Recombinant (His)

DKFZp547M2010,SLIT and NTRK like family member 4

 Human HEK293 Cells
SLIT and NTRK-like family proteins 4 is a member of the SLIT and NTRK-like family. This protein is characterized as an integral membrane protein that has two leucine-rich repeat (LRR) domains and a carboxy-terminal domain that is partially similar to SLIT protein and TRK Neurotrophin There are six members in this family: SLITRK1, SLITRK2, SLITRK3, SLITRK4, SLITRK5, and SLITRK6. Their expression was detected mainly in the brain, but the expression profile of each SLITRK was unique. Each of these ...
TMPY-00923 SLITRK1 Protein, Human, Recombinant (His)

TTM,FLJ54428,LRRC12,RP11-395N17.1,KIAA0918,SLITRK1,...

 Human HEK293 Cells
SLITRK1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 105-115 kDa and the accession number is Q96PX8.
TMPY-06967 TrkA Protein, Cynomolgus, Recombinant (His)

neurotrophic tyrosine kinase, receptor, type 1

 Cynomolgus HEK293 Cells
TrkA Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.95 kDa and the accession number is XP_005541454.3.
TMPY-03063 SLITRK6 Protein, Human, Recombinant (His)

SLIT and NTRK like family member 6,SLITRK6...

 Human HEK293 Cells
SLITRK6 belongs to the SLITRK family. Members of this family share two conserved leucine-rich repeat domains in the extracellular domain. SLITRK6 contains 11 LRR (leucine-rich) repeats, 2 LRRCT domains and 2 LRRNT domains. Expression of SlITRK proteins is highly restricted to neural and brain tumor tissues, but varies within the protein family. SLITRK6 is highly expressed in putamen with no expression in cerebral cortex. It also can be detected in adult and fetal lung and fetal liver. It can sup...
TMPY-03635 TrkB Protein, Canine, Recombinant (His)

neurotrophic tyrosine kinase, receptor, type 2

 Canine HEK293 Cells
TrkB Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.7 kDa and the accession number is XP_541264.2.
TMPY-04285 TrkA Protein, Rat, Recombinant (His)

neurotrophic tyrosine kinase, receptor, type 1

 Rat HEK293 Cells
TrkA Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.7 kDa and the accession number is A6J617.
TMPY-00922 SLITRK1 Protein, Human, Recombinant (His & hFc)

KIAA0918,KIAA1910,SLIT and NTRK like family member ...

 Human HEK293 Cells
SLITRK1 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 95 kDa and the accession number is Q96PX8.
TMPY-04663 TrkA Protein, Rabbit, Recombinant (His)

neurotrophic tyrosine kinase, receptor, type 1

 Rabbit HEK293 Cells
TrkA Protein, Rabbit, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.4 kDa and the accession number is XP_008262512.1.
TMPY-03162 TrkB Protein, Rat, Recombinant (His)

neurotrophic tyrosine kinase, receptor, type 2

 Rat HEK293 Cells
TrkB Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47.1 kDa and the accession number is Q63604.
TMPY-03560 TrkA Protein, Rat, Recombinant (hFc)

neurotrophic tyrosine kinase, receptor, type 1

 Rat HEK293 Cells
TrkA Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 69.2 kDa and the accession number is P35739.
TMPY-03712 TrkA Protein, Canine, Recombinant (His)

neurotrophic tyrosine kinase, receptor, type 1

 Canine HEK293 Cells
TrkA Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.2 kDa and the accession number is XP_851619.3.
TMPY-00945 TrkC Protein, Human, Recombinant (His)

TRKC,gp145(trkC),neurotrophic tyrosine kin...

 Human HEK293 Cells
TrkC Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.1 kDa and the accession number is Q16288-2.
TMPY-00228 TrkB Protein, Canine, Recombinant (hFc)

neurotrophic tyrosine kinase, receptor, type 2

 Canine HEK293 Cells
TrkB Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 71.2 kDa and the accession number is XP_541264.2.
TMPY-00944 TrkC Protein, Human, Recombinant (His & hFc)

TRKC,neurotrophic tyrosine kinase, receptor, type 3...

 Human HEK293 Cells
TrkC Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 72.5 kDa and the accession number is Q16288-2.
TMPY-01223 TrkC Protein, Mouse, Recombinant (His)

TrkC,Ntrk3_tv3,AW125844,neurotrophic tyros...

 Mouse HEK293 Cells
TrkC Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.1 kDa and the accession number is Q6VNS1-1.
TMPY-03711 TrkA Protein, Canine, Recombinant (hFc)

neurotrophic tyrosine kinase, receptor, type 1

 Canine HEK293 Cells
TrkA Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.3 kDa and the accession number is XP_851619.3.
TMPY-02917 TrkB Protein, Rat, Recombinant (hFc)

neurotrophic tyrosine kinase, receptor, type 2

 Rat HEK293 Cells
TrkB Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 71.5 kDa and the accession number is Q63604-1.

重组蛋白

TrkA Protein, Human, Recombinant (His)
Cat.No: TMPY-01084
Species: Human
Expression System: HEK293 Cells
TrkB Protein, Human, Recombinant (His)
Cat.No: TMPY-00751
Species: Human
Expression System: HEK293 Cells
TrkB Protein, Mouse, Recombinant (His)
Cat.No: TMPY-02231
Species: Mouse
Expression System: HEK293 Cells
TrkA Protein, Human, Recombinant (aa 194-413, His)
Cat.No: TMPY-01760
Species: Human
Expression System: HEK293 Cells
TrkA Protein, Human, Recombinant (aa 33-417, His)
Cat.No: TMPK-00774
Species: Human
Expression System: HEK293 Cells
TrkA Protein, Human, Recombinant (aa 285-413, His)
Cat.No: TMPY-01759
Species: Human
Expression System: E. coli
TrkA Protein, Human, Recombinant (His & hFc)
Cat.No: TMPY-01083
Species: Human
Expression System: HEK293 Cells
TrkA Protein, Mouse, Recombinant (His)
Cat.No: TMPY-03536
Species: Mouse
Expression System: HEK293 Cells
TrkA Protein, Mouse, Recombinant (hFc)
Cat.No: TMPY-03470
Species: Mouse
Expression System: HEK293 Cells
TrkB Protein, Human, Recombinant (hFc)
Cat.No: TMPY-05509
Species: Human
Expression System: HEK293 Cells
SLITRK4 Protein, Human, Recombinant (His)
Cat.No: TMPY-02484
Species: Human
Expression System: HEK293 Cells
SLITRK1 Protein, Human, Recombinant (His)
Cat.No: TMPY-00923
Species: Human
Expression System: HEK293 Cells
TrkA Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPY-06967
Species: Cynomolgus
Expression System: HEK293 Cells
SLITRK6 Protein, Human, Recombinant (His)
Cat.No: TMPY-03063
Species: Human
Expression System: HEK293 Cells
TrkB Protein, Canine, Recombinant (His)
Cat.No: TMPY-03635
Species: Canine
Expression System: HEK293 Cells
TrkA Protein, Rat, Recombinant (His)
Cat.No: TMPY-04285
Species: Rat
Expression System: HEK293 Cells
SLITRK1 Protein, Human, Recombinant (His & hFc)
Cat.No: TMPY-00922
Species: Human
Expression System: HEK293 Cells
TrkA Protein, Rabbit, Recombinant (His)
Cat.No: TMPY-04663
Species: Rabbit
Expression System: HEK293 Cells
TrkB Protein, Rat, Recombinant (His)
Cat.No: TMPY-03162
Species: Rat
Expression System: HEK293 Cells
TrkA Protein, Rat, Recombinant (hFc)
Cat.No: TMPY-03560
Species: Rat
Expression System: HEK293 Cells
TrkA Protein, Canine, Recombinant (His)
Cat.No: TMPY-03712
Species: Canine
Expression System: HEK293 Cells
TrkC Protein, Human, Recombinant (His)
Cat.No: TMPY-00945
Species: Human
Expression System: HEK293 Cells
TrkB Protein, Canine, Recombinant (hFc)
Cat.No: TMPY-00228
Species: Canine
Expression System: HEK293 Cells
TrkC Protein, Human, Recombinant (His & hFc)
Cat.No: TMPY-00944
Species: Human
Expression System: HEK293 Cells
TrkC Protein, Mouse, Recombinant (His)
Cat.No: TMPY-01223
Species: Mouse
Expression System: HEK293 Cells
TrkA Protein, Canine, Recombinant (hFc)
Cat.No: TMPY-03711
Species: Canine
Expression System: HEK293 Cells
TrkB Protein, Rat, Recombinant (hFc)
Cat.No: TMPY-02917
Species: Rat
Expression System: HEK293 Cells
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