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顶部生物活性储存和溶解信息计算器

Anti-DDR2 Antibody (1R524)

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Anti-DDR2 Antibody (1R524)
产品编号 TMAY-03350
别名 TYRO10, TKT, NTRKR3, MIG20a, discoidin domain receptor tyrosine kinase 2, CD167

Anti-DDR2 Antibody (1R524) 是一种 Rabbit 抗体，靶向 DDR2。Anti-DDR2 Antibody (1R524) 可用于 ELISA。

Anti-DDR2 Antibody (1R524)

Anti-DDR2 Antibody (1R524)

Rating icon 还可以
Anti-DDR2 Antibody (1R524)
产品编号 TMAY-03350 别名 TYRO10, TKT, NTRKR3, MIG20a, discoidin domain receptor tyrosine kinase 2, CD167

Anti-DDR2 Antibody (1R524) 是一种 Rabbit 抗体，靶向 DDR2。Anti-DDR2 Antibody (1R524) 可用于 ELISA。

规格价格库存数量
20 μL
¥ 795
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100 μL
¥ 2,279
5日内发货
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产品描述
Anti-DDR2 Antibody (1R524) is a Rabbit antibody targeting DDR2. Anti-DDR2 Antibody (1R524) can be used in ELISA.
别名TYRO10, TKT, NTRKR3, MIG20a, discoidin domain receptor tyrosine kinase 2, CD167
Ig Type
Rabbit IgG
克隆号
1R524
交叉反应
Mouse
应用
ELISA
推荐剂量
ELISA: 1:5000-1:10000
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Mouse DDR2 / CD167b (rM DDR2 / CD167b; TMPY-01728; NP_072075.2; Met1-Arg399).
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景Discoidin domain receptor 2 (DDR2) or CD167b (cluster of differentiation 167b) is a kind of protein tyrosine kinases associated with cell proliferation and tumor metastasis, and collagen, identified as a ligand for DDR2, up-regulates matrix metallloproteinase 1 (MMP-1) and MMP-2 expression in cellular matrix. DDR2/CD167b was found to recognise the triple-helical region of collagen X as well as the NC1 domain. Binding to the collagenous region was dependent on the triple-helical conformation. DDR2/CD167b autophosphorylation was induced by the collagen X triple-helical region but not the NC1 domain, indicating that the triple-helical region of collagen X contains a specific DDR2 binding site that is capable of receptor activation. DDR2/CD167b is induced during stellate cell activation and implicate the phosphorylated receptor as a mediator of MMP-2 release and growth stimulation in response to type I collagen. Moreover, type I collagen-dependent upregulation of DDR2/CD167b expression establishes a positive feedback loop in activated stellate cells, leading to further proliferation and enhanced invasive activity.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Mouse DDR2 / CD167b Protein (TMPY-01728)
抗原种属
Mouse
研究领域
Receptor Tyrosine Kinases (RTKs), Cancer Drug Targets
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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关键词

TYRO-10TYRO 10NTRKR-3NTRKR 3CD-167CD 167

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