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Anti-Phospho-TrkA (Tyr701) Polyclonal Antibody
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产品编号 TMAC-04122
别名 TrkA (p-Y701), TrkA (p-Tyr701), p-TrkA (Y701), p-TrkA (Tyr701)
Anti-Phospho-TrkA (Tyr701) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-TrkA (Tyr701)。Anti-Phospho-TrkA (Tyr701) Polyclonal Antibody 可用于 WB,IHC。
Anti-Phospho-TrkA (Tyr701) Polyclonal Antibody
Anti-Phospho-TrkA (Tyr701) Polyclonal Antibody
还可以产品编号 TMAC-04122 别名 TrkA (p-Y701), TrkA (p-Tyr701), p-TrkA (Y701), p-TrkA (Tyr701)
Anti-Phospho-TrkA (Tyr701) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-TrkA (Tyr701)。Anti-Phospho-TrkA (Tyr701) Polyclonal Antibody 可用于 WB,IHC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,490 | 5日内发货 | |
| 100 μL | ¥ 2,240 | 5日内发货 |
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| 产品描述 | Anti-Phospho-TrkA (Tyr701) Polyclonal Antibody is a Rabbit antibody targeting Phospho-TrkA (Tyr701). Anti-Phospho-TrkA (Tyr701) Polyclonal Antibody can be used in WB,IHC. |
| 别名 | TrkA (p-Y701), TrkA (p-Tyr701), p-TrkA (Y701), p-TrkA (Tyr701) |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | 1. Western blot analysis of extracts from mouse brain cells, using Trk A (Phospho-Tyr701) antibody TMAC-04122. The lane on the right is treated with the synthesized peptide. 2. Immunohistochemistry analysis of paraffin-embedded human brain tissue using Trk A (Phospho-Tyr701) antibody TMAC-04122. The picture on the right is treated with the synthesized peptide. |
| 应用 | |
| 推荐剂量 | WB: 1:500-3000; IHC: 1:50-100 |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Polyclonal Antibody |
| 纯化方式 | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| 性状 | Liquid |
| 缓冲液 | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | Phospho |
| 免疫原 | Peptide sequence around phosphorylation site of tyrosine 701 (I-L-Y(p)-R-K) derived from Human Trk A |
| 抗原种属 | human |
| Uniprot ID |
| 分子量 | Actual: 87 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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