DDR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.7 kDa and the accession number is A0A024RCQ1.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
100 μg | ¥ 3,820 | 现货 | ||
200 μg | ¥ 6,750 | 5日内发货 | ||
500 μg | ¥ 14,280 | 5日内发货 |
生物活性 | Testing in progress |
产品描述 | DDR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.7 kDa and the accession number is A0A024RCQ1. |
种属 | Human |
表达系统 | HEK293 Cells |
标签 | C-His |
蛋白编号 | A0A024RCQ1 |
别名 | RTK6, DDR, TRKE, PTK3, NTRK4, NEP, PTK3A, MCK10, EDDR1, HGK2, CD167, CAK, discoidin domain receptor tyrosine kinase 1 |
蛋白构建 | The extracellular domain of Human DDR1 isoform b (NP_001945.3) (Met 1-Thr 416) was expressed, with a C-terminal polyhistidine tag. |
蛋白纯度 |
> 97 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.
|
分子量 | 45.7 kDa (predicted) |
内毒素 | < 1.0 EU/μg of the protein as determined by the LAL method. |
缓冲液 | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
复溶方法 | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
存储 |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
运输方式 |
In general, Lyophilized powders are shipping with blue ice. |
研究背景 | Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 10 (MCK10), belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. Expression of DDR1/MCK10/CD167 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. DDR1/MCK10/CD167 plays an important role in regulating attachment to collagen, chemotaxis, proliferation, and MMP production in smooth muscle cells. DDR1 functions in a feedforward loop to increase p53 levels and at least some of its effectors. Inhibition of DDR1 function resulted in strikingly increased apoptosis of wild-type p53-containing cells in response to genotoxic stress through a caspase-dependent pathway. |
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DDR1 Protein, Human, Recombinant (His) RTK6 DDR TRKE MCK 10 PTK3 CD 167 NTRK-4 NTRK4 NEP PTK3A MCK10 EDDR1 RTK-6 RTK 6 HGK2 CD-167 NTRK 4 EDDR-1 HGK 2 MCK-10 EDDR 1 CD167 PTK-3 CAK HGK-2 discoidin domain receptor tyrosine kinase 1 PTK 3 recombinant recombinant-proteins proteins protein