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Anti-TrkA Antibody (2F839)
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产品编号 TMAH-00832
别名 TrkA-I, TrkAI, TrkA I, Trk-A, TRKA, TRK, NTRK1, MTC
Anti-TrkA Antibody (2F839) 是一种抗体，靶向 TrkA。Anti-TrkA Antibody (2F839) 可用于 ELISA, WB。
Anti-TrkA Antibody (2F839)
Anti-TrkA Antibody (2F839)
还可以产品编号 TMAH-00832 别名 TrkA-I, TrkAI, TrkA I, Trk-A, TRKA, TRK, NTRK1, MTC
Anti-TrkA Antibody (2F839) 是一种抗体，靶向 TrkA。Anti-TrkA Antibody (2F839) 可用于 ELISA, WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,300 | 5日内发货 | |
| 100 μL | ¥ 2,190 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-TrkA Antibody (2F839) is an antibody targeting TrkA. Anti-TrkA Antibody (2F839) can be used in ELISA, WB. |
| 别名 | TrkA-I, TrkAI, TrkA I, Trk-A, TRKA, TRK, NTRK1, MTC |
| Ig Type | Rabbit IgG |
| 克隆号 | 2F839 |
| 交叉反应 | Human, Mouse, Rat |
| 验证活性 | Western Blot -Positive WB detected in: Rat Brain whole cell lysate, Mouse Brain whole cell lysate -All lanes: TrkA Antibody at 1:1000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 88, 87, 84, 78 kDa -Observed band size: 145 kDa |
| 应用 | ELISA, WB |
| 推荐剂量 | WB:1:500-1:5000. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Cell membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Recycling endosome membrane; Single-pass type I membrane protein. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand. Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. Resistant to NGF, it constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human TrkA |
| 抗原种属 | Human |
| 基因ID | 4914 |
| Uniprot ID | |
| 研究领域 | Other |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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