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Anti-NTRK2 Antibody (8F124)
还可以产品编号 TMAH-00833
别名 trk-B, TRKB, Tkrb, neurotrophic tyrosine kinase, receptor, type 2, GP145-TrkB/GP95-TrkB, GP145-TrkB
Anti-NTRK2 Antibody (8F124) 是一种抗体，靶向 NTRK2。Anti-NTRK2 Antibody (8F124) 可用于 ELISA, IF。
Anti-NTRK2 Antibody (8F124)
Anti-NTRK2 Antibody (8F124)
还可以产品编号 TMAH-00833 别名 trk-B, TRKB, Tkrb, neurotrophic tyrosine kinase, receptor, type 2, GP145-TrkB/GP95-TrkB, GP145-TrkB
Anti-NTRK2 Antibody (8F124) 是一种抗体，靶向 NTRK2。Anti-NTRK2 Antibody (8F124) 可用于 ELISA, IF。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,315 | 5日内发货 | |
| 100 μL | ¥ 2,185 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-NTRK2 Antibody (8F124) is an antibody targeting NTRK2. Anti-NTRK2 Antibody (8F124) can be used in ELISA, IF. |
| 别名 | trk-B, TRKB, Tkrb, neurotrophic tyrosine kinase, receptor, type 2, GP145-TrkB/GP95-TrkB, GP145-TrkB |
| Ig Type | Mouse IgG2a |
| 克隆号 | 8F124 |
| 交叉反应 | Human |
| 验证活性 | Immunofluorescence staining of SH-SY5Y cell with TMAH-00833 at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG(H+L). |
| 应用 | ELISA, IF |
| 推荐剂量 | IF:1:20-1:200. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Early endosome membrane. Cell projection, axon. Cell projection, dendrite. Cytoplasm, perinuclear region. Cell junction, synapse, postsynaptic density. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| 研究背景 | Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human NTRK2 Protein |
| 抗原种属 | Human |
| 基因ID | 4915 |
| Uniprot ID | |
| 研究领域 | Others |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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