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Anti-TrkB Antibody (1M503)

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产品编号 TMAY-00167

别名 trk-B, TRKB, Tkrb, neurotrophic tyrosine kinase, receptor, type 2, GP145-TrkB/GP95-TrkB, GP145-TrkB

Anti-TrkB Antibody (1M503) 是一种 Mouse 抗体，靶向 TrkB。Anti-TrkB Antibody (1M503) 可用于 ELISA(Det)。

Anti-TrkB Antibody (1M503)

Anti-TrkB Antibody (1M503)

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Rating icon 还可以
产品编号 TMAY-00167 别名 trk-B, TRKB, Tkrb, neurotrophic tyrosine kinase, receptor, type 2, GP145-TrkB/GP95-TrkB, GP145-TrkB

Anti-TrkB Antibody (1M503) 是一种 Mouse 抗体，靶向 TrkB。Anti-TrkB Antibody (1M503) 可用于 ELISA(Det)。

规格价格库存数量
20 μL
¥ 585
5日内发货
100 μL
¥ 1,694
5日内发货
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产品介绍

生物活性
产品描述
Anti-TrkB Antibody (1M503) is a Mouse antibody targeting TrkB. Anti-TrkB Antibody (1M503) can be used in ELISA(Det).
别名trk-B, TRKB, Tkrb, neurotrophic tyrosine kinase, receptor, type 2, GP145-TrkB/GP95-TrkB, GP145-TrkB
Ig Type
Mouse IgG1
克隆号
1M503
交叉反应
Human
特异性
Human TrkB
应用ELISA(Det)
抗体种类
Monoclonal
宿主来源Mouse
构建方式This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human TrkB / NTRK2 (rh TrkB / NTRK2; TMPY-00751; NP_001007098.1; Met1-His430). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptor with intracellular tyrosine kinase activity. TrkB/NTRK2 is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TrkB tyrosine kinase (TrkB) or NTRK2 is coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3-K, and PLCgamma signaling pathways. There are four members of the Trk family; TrkA, TrkB, and TrkC and a related p75NTR receptor. Each family member binds different neurotrophins with varying affinities. TrkB/NTRK has the highest affinity for brain-derived neurotrophic factor (BDNF) and is involved in neuronal plasticity, long-term potentiation, and apoptosis of CNS neurons. Other neurotrophins includenerve growth factor(NGF), neurotrophin-3 and neurotrophin-4. TrkB/NTRK is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signaling through this kinase leads to cell differentiation. Mutations in TrkB/NTRK have been associated with obesity and mood disorders.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Human TrkB / NTRK2 Protein (TMPY-00751)
抗原种属
Human
研究领域
Receptor Tyrosine Kinases (RTKs), Cancer Drug Targets
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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